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Journal of Medical Biochemistry
2018, vol. 37, br. 3, str. 346-354
jezik rada: engleski
vrsta rada: izvorni naučni članak
objavljeno: 14/02/2020
PMC ID: PMC6298461
doi: 10.1515/jomb-2017-0056
Poređenje često upotrebljavanih biohemijskih analita u uzrocima seruma i salive pacijenata na dijalizi
aMinistry of Health, Balikesir State Hospital, Department of Clinical Biochemistry, Balikesir, Turkey
bMinistry of Health, Aydin Çine State Hospital, Department of Clinical Biochemistry, Aydin, Turkey
cMinistry of Health, Balikesir State Hospital, Department of Nephrology, Balikesir, Turkey
dMinistry of Health, Ankara Training and Research Hospital, Department of Clinical Biochemistry, Ankara, Turkey

Sažetak

Uvod: Cilj ove studije je da se utvrdi da li analiza salive predstavlja alternativu rutinskim biohemijskim analizama i imunoesejima kod pacijenata podvrgnutih peritonealnoj dijalizi (PD) ili hemodijalizi (HD). Metode: Grupu ispitanika činilo je 40 zdravih kontrolnih subjekata, 44 pacijenta na PD i 44 na HD. Mereni su rutinski biohemijski analiti, tireostimu I išući hormon (TSH), slobodni T3, slobodni T4, vitamin B12, feritin i folna kiselina. Rezultati: U poređenju sa stanjem pre HD, nivoi uree, kreatinina, mokraćne kiseline, kalijuma bili su niži posle HD, dok su nivoi kalcijuma, magnezijuma, vitamina B12 bili viši posle HD kako u salivi tako i u serumu. Pozitivne korelacije između salive i seruma nađene su za TSH i feritin u kontrolnoj grupi; ureu, LDH, K u PD; ureu, kreatinin, alkalnu fosfatazu pre HD, i gama-glutamil transferazu, gvožđe, TSH posle HD. Negativna korelacija je postojala samo za kreatin-kinazu i Mg pre HD i kalcijum posle HD. U svim grupama nađena je pozitivna korelacija za ureu, kreatinin, a negativna korelacija je nađena za magnezijum. Zaključak: Naša studija je pokazala više nivoe uree i kreatinina u salivi u grupama pacijenata, koji su odgovarali serumskim nivoima. Ovi rezultati pokazuju da bi salivarni nivoi uree i kreatinina mogli biti korisni u proceni azotemije kod pacijenata na dijalizi.

Ključne reči

krajnji stadijum bubrežne insuficijencije; hemodijaliza; peritonealna dijaliza; analiza salive; serum

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