Article metrics

  • citations in SCindeks: 0
  • citations in CrossRef:0
  • citations in Google Scholar:[=>]
  • visits in previous 30 days:3
  • full-text downloads in 30 days:2
article: 1 from 3  
Back back to result list
Timočki medicinski glasnik
2014, vol. 39, iss. 1, pp. 14-20
article language: Serbian
document type: Original Paper
doi:10.5937/tmg1401014J


Effects of intra and postoperative steroid injection of pterygium surgery
aKlinika za oftalmologiju, Klinički centar Kragujevac
bUniversity of Kragujevac, Faculty of Medicine

e-mail: mira.andreja@yahoo.com

Abstract

Introduction: Pterygium is a degenerative disease of the conjunctiva with the affection of the cornea of the eye. The aim was to determine the effects of intra and postoperative applications of the steroids in the treatment of primary and recurrent pterygium with the applications of subconjunctival intralesional injections. Methods: The study included of 62 patients (79 eyes) with primary pterygium and 57 patients (64 eyes) with recurrent pterygium. Applications of Triamcinolone acetonide (Kenolog-40) in pterygium surgery were performed in our Department of Ophthalmology, in the period 3rd May 2010 to 3rd May 2013. The medicine was administrated during and after the surgery, in two or three doses, like subconjunctival injection of steroid, with clinical monitoring and evaluation of clinical signs of regression of primary and recurrent pterygium, which was correlated with the control group. Results: In all our patients, there was a complete resolution of primary and recurrent pterygium. Recurrent pterygium appeared only in the eyes of the control group as a complete relapse whereby subconjunctival steroid therapy was not applied - not even on examinations after one, six or twelve months. Conclusion: For a complete resolution of the primary and relapse pterygium, the application of one to two intralesional, subconjunctival steroid injections is required.

Keywords

primary pterygium; recurrent pterygium; surgical treatment; Triamcinolone- acetonide

References

*** (2008) Health quality Ontario, limbal stem cell transplantation: An evidence-based analysis. Ont Health Technol Assess Ser, 8(7), 1-58
Bianchi, E., Scarinci, F., Grande, C., Plateroti, R., Plateroti, P., Plateroti, A.M., Fumagalli, L., Capozzi, P., Feher, J., Artico, M. (2012) Immunohistochemical profile of VEGF, TGF-β and PGE₂ in human pterygium and normal conjunctiva: experimental study and review of the literature. International journal of immunopathology and pharmacology, 25(3): 607-15
Bradley, J.C., Yang, W., Bradley, R.H., Reid, T.W., Schwab, I.R. (2010) The science of pterygia. British journal of ophthalmology, 94(7): 815-20
Džunić, B., Jovanović, P., Veselinović, D., Petrović, A., Stefanović, I., Kovačević, I. (2010) Analysis of pathohistological characteristics of pterygium. Bosnian journal of basic medical sciences, 10(4): 307-13
Golu, T., Mogoantă, L., Streba, C.T., Pirici, D.N., Mălăescu, D., Mateescu, G.O., Muţiu, G. (2011) Pterygium: histological and immunohistochemical aspects. Romanian journal of morphology and embryology, 52(1): 153-8
Heindl, L.M., Cursiefen, C. (2010) Pterygium. Etiology, clinical aspects and novel adjuvant therapies. Der Ophthalmologe, 107(6): 517-20, 522-4
Hosseini, H., Nowroozzadeh, M.H., Salouti, R., Nejabat, M. (2012) Anti-VEGF therapy with bevacizumab for anterior segment eye disease. Cornea, 31(3): 322-34
Kaufman, S.C., Jacobs, D.S., Lee, W. B., Deng, S.X., Rosenblatt, M.I., Shtein, R.M. (2013) Options and Adjuvants in Surgery for Pterygium. Ophthalmology, 120(1): 201-208
Kheirkhah, A., Nazari, R., Safi, H., Ghassemi, H., Behrouz, M.J., Raju, V.K. (2013) Effects of intraoperative steroid injection on the outcome of pterygium surgery. Eye, 27(8): 906-914
Kheirkhah, A., Nazari, R., Nikdel, M., Ghassemi, H., Hashemi, H., Behrouz, M.J. (2011) Postoperative conjunctival inflammation after pterygium surgery with amniotic membrane transplantation versus conjunctival autograft. American Journal of Ophthalmology, 152(5): 733-8
Lee, S., Go, J., Rhiu, S., Stulting, R., Lee, M., Jang, S., Lee, S., Kim, H.J., Chung, E.S., Kim, S., Seo, K.Y. (2013) Cosmetic regional conjunctivectomy with postoperative mitomycin C application with or without bevacizumab injection. American Journal of Ophthalmology, 156(3): 616-22.e3
Mauro, J., Foster, C. (2009) Pterygia: pathogenesis and the role of subconjunctival bevacizumab in treatment. Seminars in ophthalmology, 24(3): 130-4
Mohammed, I. (2011) Treatment of pterygium. Annals of African Medicine, 10(3): 197
Nava-Castañeda, A., Olvera-Morales, O., Ramos-Castellon, C., Garnica-Hayashi, L., Garfias, Y. (2013) Randomized, controlled trial of conjunctival autografting combined with subconjunctival bevacizumab for primary pterygium treatment: 1-year follow-up. Clinical and Experimental Ophthalmology, 42(3): 235-241
Said, D.G., Faraj, L.A., Elalfy, M.S., Yeung, A., Miri, A., Fares, U., Otri, A.M., Rahman, I., Maharajan, S., Dua, H.S. (2013) Intra-lesional 5 fluorouracil for the management of recurrent pterygium. Eye, 27(10): 1123-1129
Sekundo, W. (2010) Epidemiology of pterygium. A review. Der Ophthalmologe, 107(6): 514-6
Shenasi, A., Mousavi, F., Shoa-Ahari, S., Rahimi-Ardabili, B., Fouladi, R.F. (2011) Subconjunctival bevacizumab immediately after excision of primary pterygium: the first clinical trial. Cornea, 30(11): 1219-22
Teng, C.C., Patel, N.N., Jacobson, L. (2009) Effect of subconjunctival bevacizumab on primary pterygium. Cornea, 28(4): 468-70
Turan-Vural, E., Torun-Acar, B., Kivanc, S., Acar, S. (2011) The effect of topical 0.05% cyclosporine on recurrence following pterygium surgery. Clinical ophthalmology (Auckland, N.Z.), 5: 881-5
Uçakhan, O.O., Kanpolat, A. (2006) Combined 'symmetrical conjunctival flap transposition' and intraoperative low-dose mitomycin C in the treatment of primary pterygium. Clinical and experimental ophthalmology, 34(3): 219-25
Viani, G.A., Fonseca, E.C., de Fendi, L.I., Rocha, E.M. (2012) Conjunctival Autograft Alone or Combined With Adjuvant Beta-Radiation? A Randomized Clinical Trial. International journal of radiation oncology, biology, physics, 82(3): e507-e511
Wu, P., Kuo, H., Tai, M., Shin, S. (2009) Topical bevacizumab eyedrops for limbal-conjunctival neovascularization in impending recurrent pterygium. Cornea, 28(1): 103-4
Xu, F., Li, M., Yan, Y., Lu, K., Cui, L., Chen, Q. (2013) A novel technique of sutureless and glueless conjunctival autografting in pterygium surgery by electrocautery pen. Cornea, 32(3): 290-5