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Facta universitatis - series: Medicine and Biology
2003, vol. 10, br. 1, str. 36-40
jezik rada: engleski
vrsta rada: neklasifikovan
Odnos između brzine urinarne ekskrecije albumina i jačine glomerulske filtracije kod bolesnika sa tipom 1 dijabetes melitusa
aKlinički centar Niš
bUniverzitet u Nišu, Medicinski fakultet

e-adresa: mrajic@eunet.yu

Sažetak

Cilj ove studije je bio da se ispita odnos između brzine urinarne ekskrecije albumina i jačine glomerulske filtracije u različitim stadijumima dijabetesne bubrežne bolesti kod bolesnika sa tipom 1 dijabetes melitus-a. Prema brzini urinarne ekskrecije albumina i nivou serumskog kreatinina sedamdeset bolesnika sa tipom 1 dijabetes melitus-a raspoređeno je u grupu sa normoalbuminurijom, mikroalbuminurijom, makroalbuminurijom i hroničnom bubrežnom slabošću, dok je kontrolnu grupu činilo 23 zdravih ispitanika. Jačina glomerulske filtracije procenjivana je plazmatskim klirensom 99mTc-DTPA. Srednja vrednost klirensa 99mTc-DTPA bila je značajno povišena u bolesnika sa normoalbuminurijom (p<0,005), neizmenjena u bolesnika sa mikroalbuminurijom i snižena u bolesnika sa makroalbuminurijom i bubrežnom insuficijenciom (p<0,0001). Statistički značajna korelacija između ekskrecije albumina urinom i glomerulske filtracije dokazana je samo u makroalbuminuriji (r= −0,588 p=0,008). Dobijeni rezultati su pokazali da se poremećaj glomerulske filtracije javlja pre povećanja ekskrecije albumina urinom i da predstavlja pouzdaniji indikator renalnog funkcionog oštećenja u dijabetesnoj bubrežnoj bolesti.

Ključne reči

Dijabetes melitus tip 1; brzina urinarne ekskrecije albumina; jačina glomerulske filtracije

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