Metrika članka

  • citati u SCindeksu: 0
  • citati u CrossRef-u:0
  • citati u Google Scholaru:[=>]
  • posete u poslednjih 30 dana:5
  • preuzimanja u poslednjih 30 dana:5
članak: 3 od 11  
Back povratak na rezultate
Vojnosanitetski pregled
2014, vol. 71, br. 10, str. 931-935
jezik rada: engleski
vrsta rada: izvorni naučni članak
objavljeno: 10/10/2014
doi: 10.2298/VSP1410931J
Uticaj bakterijske vaginoze na nedelju završetka porođaja i biohemijske markere inflamacije u serumu
aKlinički centar Vojvodine, Centar za laboratorijsku medicinu, Novi Sad + Univerzitet u Novom Sadu, Medicinski fakultet
bUniverzitet u Novom Sadu, Medicinski fakultet + Klinički centar Vojvodine, Klinika za ginekologiju i akušerstvo, Novi Sad
cUniverzitet u Novom Sadu, Medicinski fakultet
dVojnomedicinska akademija, Klinika za kardiologiju, Beograd + Univerzitet odbrane, Medicinski fakultet Vojnomedicinske akademije, Beograd

e-adresa: jakovana@gmail.com

Sažetak

Uvod/Cilj. Prevremeni porođaj predstavlja jednu od najčešćih akušerskih komplikacija, i kod 75-80% slučajeva uzročnik je neonatalnog mortaliteta. Bakterijska vaginoza smatra se značajnim faktorom rizika od prevremenog porođaja, prevremene rupture plodovih ovojaka i pobačaja. Nastaje kao posledica redukcije laktobacila koji proizvode protektivni H2O2, sa preovladavanjem anaerobnih, gram-negativnih i drugih nepovoljnih bakterija. Cilj ovog rada bio je da se utvrdi da li bakterijska vaginoza kod trudnica ima uticaja na nedelju završetka porođaja kao i na biohemijske markere in- flamacije u serumu. Metode. Studija je obuhvatila ukupno 186 trudnica, između 16. i 19. nedelje gestacije. Ispitanice su bile podeljene na grupu sa dokazanom bakterijskom vaginozom po Amselovim i Njudžentovim kriterijumima (n = 76) i kontrolnu grupu sa normalnom bakterijskom florom (n = 110). Svim trudnicama je urađen ultrazvučni pregled, uzet bris vaginalnog sekreta i uzorak krvi za određivanje biohemijskih markera inflamacije kolorimetrijskim metodama. Rezultati. Nedelja završetka porođaja bila je statistički značajno kraća kod trudnica sa bakterijskom vaginozom u odnosu na kontrolnu grupu, dok su biohemijski markeri inflamacije, C-reaktivni protein i fibrinogen, bili statistički značajno viši u ispitivanoj grupi nego u kontrolnoj grupi. Takođe, vrednosti mokraćne kiseline i ukupnih leukocita bile su više u ispitivanoj u odnosu na kontrolnu grupu. Zaključak. Naša istraživanja ukazuju na znatno raniji završetak porođaja kod trudnica sa bakterijskom vaginozom, kao i na to da više vrednosti biohemijskih markera inflamacije u serumu ispitivane grupe, slično drugim istraživanjima, sugerišu da se patofiziološki procesi odgovorni za prevremeni porođaj mogu javiti vrlo rano u trudnoći.

Ključne reči

Reference

Amsel, R., Totten, P.A., Spiegel, C.A., Chen, K.C., Eschenbach, D., Holmes, K.K. (1983) Nonspecific vaginitis: Diagnostic criteria and microbial and epidemiologic associations. Am J Med, 74(1): 14-22
Balu, R.B., Savitz, D.A., Ananth, C.V., Hartmann, K.E., Miller, W.C., Thorp, J.M., Heine, P.R. (2003) Bacterial vaginosis, vaginal fluid neutrophil defensins, and preterm birth. Obstet Gynecol, 101(5 Pt 1): 862-8
Bogavac, M., Lakic, N., Simin, N., Nikolic, A., Sudji, J., Bozin, B. (2012) Bacterial vaginosis and biomarkers of oxidative stress in amniotic fluid. journal of maternal-fetal & neonatal medicine, 25(7): 1050-4
Bogavac, M., Brkić, S., Simin, N., Grujić, Z., Božin, B. (2010) Do bacterial vaginosis and chlamydial infection affect serum cytokine level?. Srpski arhiv za celokupno lekarstvo, vol. 138, br. 7-8, str. 444-448
Carey, C.J., Klebanoff, M.A. (2003) What have we learned about vaginal infections and preterm birth?. Semin Perinatol, 27(3): 212-6
Carey, J.C., Klebanoff, M.A. (2005) Is a change in the vaginal flora associated with an increased risk of preterm birth?. Am J Obstet Gynecol, 192: 134
Daskalakis, G., Papapanagiotou, A., Mesogitis, S., Papantoniou, N., Mavromatis, K., Antsaklis, A. (2006) Bacterial vaginosis and group B streptococcal colonization and preterm delivery in a low-risk population. Fetal Diagn Ther, 21(2): 172-6
de Seta, F., Sartore, A., Piccoli, M., Maso, G., Zicari, S., Panerari, F., Guaschino, S. (2005) Bacterial vaginosis and preterm delivery: an open question. J Reprod Med, 50(5): 313-8
Donders, G.G., Calstere, K.V., Bellen, G., Reybrouck, R., Bosch, T., Riphagen, I., i dr. (2009) Predictive value for preterm birth of abnormal vaginal flora, bacterial vaginosis and aerobic vaginitis during the first trimester of pregnancy. Inter J Obstet Gynaecol, 116: 131
Donders, G.G., van Bulck, B., Caudron, J., Londers, L., Vereecken, A., Spitz, B. (2000) Relationship of bacterial vaginosis and mycoplasmas to the risk of spontaneous abortion. Am J Obstet Gynecol, 183(2): 431-7
Donders, G.G., Spitz, B., Vereecken, A., van Bulck, B., Cornelis, A., Dekeersmaeker, A., i dr. (2008) The ecology of the vaginal flora at first prenatal visit is associated with preterm delivery and low birth weight. Open Infect Dis J, 2: 45-51
Donders, G.G., Bosmans, E., Dekeersmaecker, A., Vereecken, A., van Bulck, B., Spitz, B. (2000) Pathogenesis of abnormal vaginal bacterial flora. Am J Obstet Gynecol, 182(4): 872-8
Donders, G.G.G. (2007) Definition and classification of abnormal vaginal flora. Best Pract Res Clin Obstet Gynaecol, 21(3): 355-73
Goldenberg, R.L., Hauth, J.C., Andrews, W.W. (2000) Intrauterine infection and preterm delivery. N Engl J Med, 342(20): 1500-7
Goldenberg, R.L., Goepfert, A.R., Ramsey, P.S. (2005) Biochemical markers for the prediction of preterm birth. Am J Obstet Gynecol, 192: 36
Guerra, B., Ghi, T., Quarta, S., Morselli-Labate, A.M., Lazzarotto, T., Pilu, G., Rizzo, N. (2006) Pregnancy outcome after early detection of bacterial vaginosis. Eur J Obstet Gynecol Reprod Biol, 128(1-2): 40-5
Hillier, S.L., Nugent, R.P., Eschenbach, D.A., Krohn, M.A., Gibbs, R.S., Martin, D.H., Cotch, M.F., Edelman, R., Pastorek, J.G., Rao, A.V. (1995) Association between bacterial vaginosis and preterm delivery of a low-birth-weight infant. The Vaginal Infections and Prematurity Study Group. N Engl J Med, 333(26):1737-42
Hirnl, L., Malolepsza-Jarmolowska, K., Kubis, A.A., Hirnle, P. (2006) Evaluation of bacterial vaginosis therapy in pregnant women with vaginal tablets containing lactic acid complexed with Eudragit® E-100 which undergo gelation at the site of applicatio. Adv clin exp med, 15(4); 645-51
Klebanoff, M.A., Hillier, S.L., Nugent, R.P., MacPherson, C.A., Hauth, J.C., Carey, C.J., Harper, M., Wapner, R.J., Trout, W., Moawad, A., Leveno, K.J., Miodovnik, M. (2005) Is bacterial vaginosis a stronger risk factor for preterm birth when it is diagnosed earlier in gestation?. Am J Obstet Gynecol, 192(2): 470-7
Krupa, F.G., Faltin, D., Cecatti, J.G., Sunita, F.G.C., Souza, J.P. (2006) Predictors of preterm birth. IJ of Gynaecol and obstet, 94: 5-11
Leitich, H. (2007) Asymptomatic bacterial vaginosis and intermediate flora as risk factors for adverse pregnancy outcome. Clin Obstet and Gynaecol, 21: 375
Leitich, H., Bodner-Adler, B., Brunbauer, M., Kaider, A., Egarter, C., Pusslein, P. (2003) Bacterial vaginosis as a risk factor for preterm delivery: A meta-analysis. Am J Obstet Gynecol, 189: 139
Manns-James, L. (2011) Bacterial vaginosis and preterm birth. J Midwifery Womens Health, 56(6): 575-83
Menard, J., Bretelle, F. (2012) Bacterial vaginosis and preterm delivery. Gynécologie, obstétrique & fertilité, 40(1): 48-54
Mitchell, C.M., Hitti, J.E., Agnew, K.J., Fredricks, D.N. (2009) Comparison of oral and vaginal metronidazole for treatment of bacterial vaginosis in pregnancy: impact on fastidious bacteria. BMC Infectious Diseases, 9(1): 89
Nelson, D.B., Macones, G. (2002) Bacterial vaginosis in pregnancy: current findings and future directions. Epidemiol Rev, 24(2): 102-8
Nugent, R.P., Krohn, M.A., Hillier, S.L. (1991) Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation. J Clin Microbiol, 29(2): 297-301
Oakeshott, P., Hay, P., Hay, S., Steinke, F., Rink, E., Kerry, S. (2002) Association between bacterial vaginosis or chlamydial infection and miscarriage before 16 weeks' gestation: prospective community based cohort study. BMJ, 325(7376): 1334-1334
Odendaal, H.J., Popov, I., Schoeman, J., Smith, M., Grové, D. (2002) Preterm labour - is bacterial vaginosis involved?. S Afr Med J, 92(3): 231-4
Riggs, M.A., Klebanoff, M.A. (2004) Treatment of Vaginal Infections to Prevent Preterm Birth: A Meta-Analysis. Clinical Obstetrics and Gynecology, 47(4): 796-807
Romero, R., Chaiworapongsa, T., Kuivaniemi, H., Tromp, G. (2004) Bacterial vaginosis, the inflammatory response and the risk of preterm birth: a role for genetic epidemiology in the prevention of preterm birth. Am J Obstet Gynecol, 190(6): 1509-19
Simhan, H.N., Caritis, S.N. (2007) Prevention of preterm delivery. N Engl J Med, 357(5): 477-87
Simhan, H.N., Caritis, S.N., Krohn, M.A., Hillier, S.L. (2005) The vaginal inflammatory milieu and the risk of early premature preterm rupture of membranes. Am J Obstet Gynecol, 192(1): 213-8
Subtil, D., Denoit, V., Le, G.F., Husson, M., Trivier, D., Puech, F. (2002) The role of bacterial vaginosis in preterm labor and preterm birth: a case-control study. Eur J Obstet Gynecol Reprod Biol, 101(1): 41-6
Thorsen, P., Vogel, I., Olsen, J., Jeune, B., Westergaard, J.G., Jacobsson, B., i dr. (2006) Bacterial vaginosis in early pregnancy is associated with low birth weight and small for gestational age, but not with spontaneous preterm birth: A population-based study on Danish women. J Mat-Fetal Neon Med, 19, str. 1-7
Ugwumadu, A.H.N. (2002) Bacterial vaginosis in pregnancy. Curr Opin Obstet Gynecol, 14(2): 115-8