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2014, vol. 30, br. 2, str. 233-242
Haplotipska veza leptin gena ovce i priplodne vrednosti telesnih mera ovaca rase Makooei
aYoung Researchers and Elite Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran
bUrmia University, Faculty of Agriculture, Department of Animal Science, Urmia, Iran

e-adresam.bohlouli@tabrizu.ac.ir
Ključne reči: Body measurements; leptin; polymorphism; breeding value; Makooei sheep
Sažetak
Istraživanje je imalo za cilj da se pronađu veze između genetskih varijacija u egzonu 3 leptin gena i priplodne vrednosti osobine telesne težine ovaca rase Makooei, koristeći jedinstveni lanac usaglašenosti polimorfizma (Single strand conformation polymorphism - SSCP). PCR proizvod koji je dobijen obuhvata egzon 3 leptin gena koji odgovara ovčijem leptin genu. PCR fragmenti su podvrgnuti elektroforezi kako bi se otkrili SSCP obrasci. Od ukupno 130 ovaca, pet SSCP obrazaca (haplotipova) je identifikovano za amplifikovane fragmente. Učestalosti SSCP obrazaca polimorfnog fragmenta su bile 0,09, 0,17, 0,37, 0,14 i 0,23. Odnos između različitih haplotipova i telesnih mera, uključujući dužinu tela (BL), obim (HG), visinu grebena (HV), visinu krsta (HB), dužinu krsta (RL) i obim testisa (SB) je utvrđen kod svih analiziranih životinja. Prema našim rezultatima, postoji značajna povezanost između različitih haplotipova ovog fragmenta sa aditivima procenjene priplodne vrednosti za HG i RL osobine. Ovi rezultati potvrdili su potencijalnu korisnost leptin gena u programima marker asistirane selekcije u ovčarstvu za odgoj Makooei rase ovaca.
Reference
Baratta, M. (2002) Leptin-from a signal of adiposity to a hormonal mediator in peripheral tissues. Med. Sci. Monitor, 8, 282-292
Boucher, D., Palin, M.F., Castonguay, F., Gariepy, C., Pothier, F. (2006) Detection of polymorphisms in the ovine leptin (LEP) gene: Association of a single nucleotide polymorphism with muscle growth and meat quality traits. Canadian Journal of Animal Science, 86, 31-35
Buchanan, F.C., van Kessel, A.G., Waldner, C., Christensen, D.A., Laarveld, B., Schmutz, S.M. (2003) Hot topic: An association between a leptin single nucleotide polymorphism and milk and protein yield. Journal of Dairy Science, 86, 3164-3166
Geary, T.W., McFadin, E.L., MacNeil, M.D., Grings, E.E., Short, R.E., Funston, R.N., Keisler, D.H. (2003) Leptin as a predictor of carcass composition in beef cattle. Journal of animal science, 81(1): 1-8
Hager, J., Clement, K., Francke, S., Dina, C., Raison, J., Lahlou, N., Rich, N., Pelloux, V., Basdevant, A., Guy-Grand, B., North, M., Froguel, P. (1998) A polymorphism in the 5′ untranslated region of the human ob gene is associated with low leptin levels. International Journal of Obesity, 22(3): 200-205
Hajihosseinlo, A., Hashemi, A., Sadeghi, S. (2012) Association between polymorphism in exon 3 of leptin gene and growth traits in the Makooei sheep of Iran. Livestock Research for Rural Development, 24, 9
Halaas, J.L., Gajiwala, K.S., Maffei, M., Cohen, S.L., Chait, B.T., Rabinowitz, D., Lallone, R.L., Burley, S.K., Friedman, J.M. (1995) Weight-reducing effects of the plasma protein encoded by the obese gene. Science, 269(5223): 543-6
Houseknecht, K.L., Baile, C.A., Matteri, R.L., Spurlock, M.E. (1998) The biology of leptin: A review. J Anim Sci, 76(5): 1405-20
Institute Inc SAS (2002) The SAS System for Windows. Cary, NC: SAS Institute Inc
Kaygisiz, A., Bengi, C., Cilek, S. (2011) Investigation of Leptin gene polymorphisms in east Anatolian, Red Anatolian and black cattle and determination of genetic distance from Brown Swiss cattle. Journal of Animal and Plant Science, 21, 121-125
Kulig, H., Kmieć, M. (2009) Association between leptin gene polymorphisms and growth traits in Limousin cattle. Russian Journal of Genetics, 45(6): 738-741
Kuryl, J., Kapelanski, W., Pierzchala, M., Bocian, M., Grajewska, S. (2003) A relationship between genotypes at the GH and LEP loci and carcass meat and fat deposition in pigs. Anim. Sci. Papers and Reports, 21, 15-26
La, C.A., Matarese, G. (2004) The weight of leptin in immunity. Nature reviews. Immunology, 4(5): 371-9
Lagonigro, R., Wiener, P., Pilla, F., Woolliams, J.A., Williams, J.L. (2003) A new mutation in the coding region of the bovine leptin gene associated with feed intake. Animal Genetics, 34(5): 371-374
Liefers, S.C., te Pas, M.F.W., Veerkamp, R.F., Chilliard, Y., Delavaud, C., Gerritsen, R., van der Lende, T. (2003) Association of leptin gene polymorphisms with serum leptin concentration in dairy cows. Mammalian genome, 14(9): 657-63
Meyer, K. (1989) Restricted maximum likelihood to estimate variance components for animal models with several random effects using a derivative-free algorithm. Genetics Selection Evolution, 21(3): 317
Nkrumah, J.D., Li, C., Basarab, J.A., Guercio, S., Meng, Y., Murdoch, B., Hansen, C., Moore, S.S. (2004) Association of a single nucleotide polymorphism in the bovine leptin gene with feed intake, growth, feed efficiency, feeding behaviour and carcass merit. Can. J. Anim. Sci., 84:211-219
Ohshiro, Y., Ueda, K., Nishi, M., Ishigame, M., Wakasaki, H., Kawashima, H., Furuta, H., Sasaki, H., Sanke, T., Takasu, N., Nanjo, K. (2000) A polymorphic marker in the leptin gene associated with Japanese morbid obesity. Journal of Molecular Medicine, 78(9): 516-520
Perucatti, A., di Meo, G.P., Vallinoto, M., Kierstein, G., Schneider, M.P.C., Incarnato, D., Caputi, J.A., Mohammadi, G., Vonghia, G., Silva, A., Brenig, B., Iannuzzi, L. (2006) FISH-mapping of LEP and SLC26A2 genes in sheep, goat and cattle R-banded chromosomes: comparison between bovine, ovine and caprine chromosome 4 (BTA4/OAR4/CHI4) and human chromosome 7 (HSA7). Cytogenetic and Genome Research, 115(1): 7-9
Schenkel, F.S., Miller, S.P., Ye, X., Moore, S.S., Nkrumah, J.D., Li, C., Yu, J., Mandell, I.B., Wilton, J.W., Williams, J.L. (2005) Association of single nucleotide polymorphisms in the leptin gene with carcass and meat quality traits of beef cattle. Journal of Animal Science, 83(9): 2009-20
Shojaei, M., Mohammadabadi, M.R., Fozi, A.M., Esmailizadeh, K.A., Ferdowsi, M.H., Torabi, A., Tayyarzadeh, M., Sadeghi, 242 M.H.S., et al. (2010) Using PCR-SSCP technique to investigate polymorphism of leptin gene in Kermani sheep. Animal Science Research, 20, 115-122
Tahmoorespur, M., Nassiry, M.R., Ansary, M., Heravimousavi, A., Vale, V.M., Eftekhari, S.F. (2009) Analysis of leptin gene polymorphism and their association with average daily gain trait in Baluchi sheep. u: 3rd Conf. of animal science, Mashhad, Iran, Prod., in Persion
van der Lende, T., te Pas, M.F.W., Veerkamp, R.F., Liefers, S.C. (2005) Leptin Gene Polymorphisms and Their Phenotypic Associations. Vitamins and Hormones, 71, 373-404
Yazdani, H., Rahmani, H.R., Edris, M.A., Dirandeh, E. (2010) Association between A59V polymorphism in exon 3 of leptin gene and reproduction traits in cows of Iranian Holstein. African Journal of Biotechnology, 9, 5997-6000
Zhou, H., Hickford, J.G.H., Gong, H. (2009) Identification of allelic polymorphism in the ovine leptin gene. Molecular biotechnology, 41(1): 22-5
Zwierchowski, L., Oprzadek, J., Dymnicki, E., Dzierzbicki, P. (2001) An Association of growth hormone k-casein, β-lactoglobulin, leptin and Pit-I loci polymorphism with growth rate and carcass traits in beef cattle. Animal Science Papers and Reports, 19, 65-78
 

O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
DOI: 10.2298/BAH1402233S
objavljen u SCIndeksu: 21.05.2015.