Metrika

  • citati u SCIndeksu: 0
  • citati u CrossRef-u:0
  • citati u Google Scholaru:[]
  • posete u poslednjih 30 dana:2
  • preuzimanja u poslednjih 30 dana:1

Sadržaj

članak: 6 od 9  
Back povratak na rezultate
2008, vol. 27, br. 4, str. 401-408
Tajni život masti - šta masne ćelije čine za regulaciju metabolizma
Medical University of Sofia, Chair of Clinical Laboratory and Clinical Immunology, Sofia, Bulgaria
Ključne reči: adipociti; adipokini; endokrina kontrola
Sažetak
Adipozno tkivo se dugo smatralo organom čija je jedina svrha skladištenje viška energije u obliku triglicerida i otpuštanje energije u obliku slobodnih masnih kiselina, što samo po sebi predstavlja neophodni sistem samoodbrane u cilju preživljavanja tokom gladovanja. Takav stav je danas izmenjen, a masno tkivo se pokazalo kao endokrini i sekretorni organ koji utiče na nekoliko metaboličkih puteva. Njegova glavna endokrina funkcija je lučenje izvesnog broja hormona, pre svega leptina i adiponektina. Adipozno tkivo takođe otpušta adipokine uključene u inflamaciju i hemostazu: faktore rasta (TNFa, transformišući faktor rasta-beta, nervni faktor rasta, VEGF), citokine (IL-1g, IL-6, IL-10), hemokine (IL-8), proteine akutne faze (haptoglobin, serumski amiloid A) i protrombotski faktor (plazminogen aktivator inhibitor-1). Cilj ove studije je da predstavi predmete odabranih skorašnjih istraživanja adipokina koji bi mogli imati poseban značaj.
Reference
Brendt, J., Kling, N., Kralishc, S., i dr. (2005) Plasma visfatin concentrations and fat depot-specific mRNA expression in humans. Diabetes, 54(10): 2911
Cianflone, K., Maslowska, M., Sniderman, A.D. (1999) Acylation stimulating protein (ASP), an adipocyte autocrine: New directions. Semin Cell Dev Biol, 10(1): 31-41
Cnop, M., Havel, P.J., Utzschneider, K.M., Carr, D.B., Sinha, M.K., Boyko, E.J., Retzlaff, B.M., Knopp, R.H., Brunzell, J.D., Kahn, S.E. (2003) Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: Evidence for independent roles of age and sex. Diabetologia, 46(4): 459-69
Cohen, S.L., Halaas, J.L., Friedman, J.M., Chait, B.T., Bennett, L., Chang, D., Hecht, R., Collins, F. (1996) Human leptin characterization. Nature, 382(6592): 589
Cook, K.S., Min, H.Y., Johnson, D., Chaplinsky, R.J., Flier, J.S., Hunt, C.R., Spiegelman, B.M. (1987) Adipsin: A circulating serine protease homolog secreted by adipose tissue and sciatic nerve. Science, 237(4813): 402-5
de Mota, N., Reaux-Goazigo, A., el Messari, S., Chartrel, N., Roesch, D., Dujardin, C., Kordon, C., Vaudry, H., Moos, F., Llorens-Catherine (2004) Apelin, a potent diuretic neuropeptide counteracting vasopressin actions through inhibition of vasopressin neuron activity and vasopressin release. Proc Natl Acad Sci USA, 101(28): 10464-9
Emanuele, E., Falcone, C., D'Angelo, A., i dr. (2006) Association of plasma eotaxin levels with the presence and extent of angiographic coronary artery disease. Atherosclerosis, 186(1): 140
Fried, S.K., Ricci, M.R., Russell, C.D., Laferrere, B. (2000) Regulation of leptin production in humans. J Nutr, 130(12): 3127S-3131S
Friedman, J.M., Halaas, J.L. (1998) Leptin and the regulation of body weight in mammals. Nature, 395(6704): 763-70
Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., i dr. (2005) Visfatin: A protein secreted by visceral fat that mimics the effects of insulin. Science, 307, str. 426-30
Gregoire, F.M., Smas, C.M., Sul, H.S. (1998) Understanding adipocyte differentiation. Physiol Rev, 78, str. 783-809
Halaas, J.L., Boozer, C., Blair, J., Fidahusein, N., Denton, D.A., Friedman, J.M. (1997) Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc Natl Acad Sci USA, 94(16): 8878-83
Halaas, J.L., Gajiwala, K.S., Maffei, M., Cohen, S.L., Chait, B.T., Rabinowitz, D., Lallone, R.L., Burley, S.K., Friedman, J.M. (1995) Weight-reducing effects of the plasma protein encoded by the obese gene. Science, 269(5223): 543-6
Havel, P.J. (2000) Role of adipose tissue in body-weight regulation: Mechanisms regulating leptin production and energy balance. Proc Nutr Soc, 59, str. 359-371
Havel, P.J. (2004) Update on adipocyte hormones: Regulation of energy balance and carbohydrate/lipid metabolism. Diabetes, 53 Suppl 1: S143-51
Hegener, H.H., Lee, I.M., Cook, N.R., i dr. (2006) Association of adiponectin gene variations with risk of incident myocardial infarction and ischemic stroke: A nested case-control study. Clinical Chemistry, 52(11): 2021
Iyengar, P., Combs, T.P., Shah, S.J., i dr. (2003) Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization. Oncogene, 22(41): 6408-23
Kantarzis, K., Rittig, K., Balletshofer, B., i dr. (2006) The relationships of plasma adiponectin with a favorable lipid profile, decreased inflammation, and less ectopic fat accumulation depend on adiposity. Clinical Chemistry, 52(10): 1934
Kim, K.H., Lee, K., Moon, Y.S., Sul, H.S. (2001) A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation. J Biol Chem, 276(14): 11252-6
Koerner, A., Kratzsch, J., Kiess, W. (2005) Adipocytokines: Leptin - the classical, resistin - the controversial, adiponectin - the promissing, and more to come. Best Practice and Research Clinical Endocrinology and Metabolism, 19(4): 525
Kubota, N., Terauchi, Y., Yamauchi, T., Kubota, T., Moroi, M., Matsui, J., Eto, K., Yamashita, T., Kamon, J., Satoh, H., Yano, W., Froguel, P., Nagai, R., Kimura, S., Kadowaki, T., Noda, T. (2002) Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem, 277(29): 25863-6
Lin, Y., Rajala, M.W., Berger, J.P., Moller, D.E., Barzilai, N., Scherer, P.E. (2001) Hyperglycemia-induced production of acute phase reactants in adipose tissue. J Biol Chem, 276(45): 42077-83
Maffei, M., Fei, H., Lee, G.H., Dani, C., Leroy, P., Zhang, Y., i dr. (1995) Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proc Natl Acad Sci USA, 92, str. 6957-60
Maffei, M., Halaas, J., Ravussin, E., Pratley, R.E., Lee, G.H., Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganathan, S. (1995) Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med, 1(11): 1155-61
Matsuzawa, Y. (2006) Therapy Insight: Adipocytokines in metabolic syndrome and related cardiovascular disease. Nature Clinical Practice Cardiovascular Medicine, 3(1): 35
Moon, B.C., Friedman, J.M. (1997) The molecular basis of the obese mutation in ob2J mice. Genomics, 42(1): 152-6
Nawrocki, A.R., Scherer, P.E. (2005) Keynote review: The adipocyte as a drug discovery target. Drug Discov Today, 10(18): 1219-30
Ronti, T., Lupattelli, G., Mannarino, E. (2006) The endocrine function of adipose tissue: An update. Clinical Endocrinology (Oxford, United Kingdom), 64(4), 355-365
Scherer, P.E. (2006) Adipose tissue: From lipid storage compartment to endocrine organ. Diabetes, 55, str. 1537-1545
Schulze, M.B., Rimm, E.B., Shai, I., Rifai, N., Hu, F.B. (2004) Relationship between adiponectin and glycemic control, blood lipids, and inflammatory markers in men with type 2 diabetes. Diabetes Care, 27(7): 1680-7
Selvarajan, S., Lund, L.R., Takeuchi, T., Craik, C.S., Werb, Z. (2001) A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiation. Nat Cell Biol, 3(3): 267-75
Steppan, C.M., Bailey, S.T., Bhat, S., Brown, E.J., Banerjee, R.R., Wright, C.M., Patel, H.R., Ahima, R.S., Lazar, M.A. (2001) The hormone resistin links obesity to diabetes. Nature, 409(6818): 307-12
Steppan, C.M., Brown, E.J., Wright, C.M., Bhat, S., Banerjee, R.R., Dai, C.Y., Enders, G.H., Silberg, D.G., Wen, X., Wu, G.D., Lazar, M.A. (2001) A family of tissue-specific resistin-like molecules. Proc Natl Acad Sci USA, 98(2): 502-506
Vasudevan, A.R., Wu, M., Xydakis, A.M., Jones, P.H., i dr. (2006) Eotaxin and obesity. Journal of Clinical Endocrinology and Metabolism, 91(1): 256
Yang, Q., Graham, T.E., Mody, N., Preitner, F., Peroni, O.D., Zabolotny, J.M., Kotani, K., Quadro, L., Kahn, B.B. (2005) Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature, 436(7049): 356-62
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., Friedman, J.M. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature, 372(6505): 425-32
Zhao, L., Gregoire, F., Sul, H.S. (2000) Transient induction of ENC-1, a Kelch-related actin-binding protein, is required for adipocyte differentiation. J Biol Chem, 275(22): 16845-50
 

O članku

jezik rada: engleski
vrsta rada: pregledni članak
DOI: 10.2478/v10011-008-0023-2
objavljen u SCIndeksu: 01.12.2008.

Povezani članci