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Srpski arhiv za celokupno lekarstvo
2011, vol. 139, br. 5-6, str. 402-408
jezik rada: srpski
vrsta rada: prikaz
doi:10.2298/SARH1106402D


Savremena saznanja o bakterijskoj vaginozi
Univerzitet u Beogradu, Medicinski fakultet, Institut za mikrobiologiju i imunologiju

e-adresa: bobadi@sezampro.rs

Sažetak

Bakterijska vaginoza, ranije označavana kao 'nespecifični vaginitis' (anaerobna vaginoza) zbog nemogućnosti izolovanja specifične bakterije koja je izaziva, danas je najčešći vaginalni sindrom kod žena u reproduktivnom periodu, s učestalošću od 15% do 30%. Ovaj sindrom, čija su etiologija i patogeneza još nedovoljno objašnjene, odlikuje se značajnim izmenama u ekosistemu vagine. Izmene se ogledaju u smanjenom broju laktobacila i značajno povećanom broju anaerobnih bakterija. Bakterije adherišu za deskvamirane epitelne ćelije, koje se nazivaju clue ćelije. Najznačajnije tegobe kod žena sa bakterijskom vaginozom su pojačan vaginalni sekret neprijatnog mirisa. Međutim, značajan broj žena s vaginozom nema nikakvih simptoma. Bakterijska vaginoza se može komplikovati različitim ginekološkim i akušerskim problemima, kao što su cervicitis, cervikalna neoplazija, pelvično inflamatorno oboljenje, postoperacione infekcije i prevremeni porođaj. Dijagnoza se najčešće postavlja na osnovu direktnog preparata vaginalnog sekreta obojenog po Gramu (Njudžentova skoring-metoda). Metronidazol i klindamicin su lekovi izbora u lečenju žena sa bakterijskom vaginozom. Preovladava stav da treba lečiti žene sa simptomima oboljenja. Žene sa simptomatskom bakterijskom vaginozom koje imaju česte relapse po pravilu loše reaguju na terapiju. Da bi lečenje ovih žena bilo efikasnije, neophodno je bolje poznavanje svih faktora važnih za patogenezu ovog sindroma.

Ključne reči

Reference

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