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Veterinarski glasnik
2008, vol. 62, br. 5-6, str. 329-340
jezik rada: srpski
vrsta rada: pregledni članak
objavljeno: 29/11/2016
doi: 10.2298/VETGL0806329B
Rezistencija bakterija mlečne kiseline na antimikrobne lekove
Univerzitet u Beogradu, Fakultet veterinarske medicine

Sažetak

Saznanja o rezistenciji na antimikrobne lekove bakterija mlečne kiseline su još uvek ograničena, verovatno zbog velikog broja rodova i vrsta koje postoje kod ove grupe, kao i zbog razlika u njihovom spektru rezistencije. Evropska agencija za bezbednost hrane EFSA smatra rezistentnost na antimikrobne lekove, posebno prenosive rezistencije, važnim kriterijumom kod donošenja odluke o kvalifikovanoj proceni bezbednosti -QPS statusu određenog soja. Ne postoje prihvaćeni standardi za fenotipsku ili genotipsku evaluaciju rezistencije na antimikrobne lekove kod izolata hrane. Takođe, izbor medija je problematičan, kao i specifikacija minimalne inhibitorne koncentracije MIC vrednosti kao posledica velikih varijacija u vrsti i moguće rezultirajuće varijacije u MIC vrednostima između vrsta i roda. Tekuća istraživanja u ovoj oblasti pokazala su da bi se na kraju mogao dobiti niz različitih MIC vrednosti specifičnih za vrstu ili rod koje bi mogle još više da prodube sadašnju kompleksnost. Još jedan problem koji postoji u vezi sa određivanjima bezbednosti starter sojeva jeste da, kada se jednom identifikuju fenotip rezistencije i asocirana determinanta rezistencije, postaje teško da se pokaže da ta determinanta nije prenosiva, posebno ukoliko se gen rezistencije ne nalazi na plazmidu i ukoliko nema standardnih protokola za prikazivanje genetskog transfera. Usled postojanja takvih problema, sistem o kvalifikovanoj proceni bezbednosti QPS treba da ostavi prostora za interpretaciju rezultata, posebno kada se oni odnose na metodologiju određivanja fenotipa rezistencije, određivanje MIC vrednosti za određeni rod, vrstu, ili soj, na nemogućnost ustanovljavanja genetske baze fenotipa rezistencije, kao i prenosivost gena rezistencije.

Ključne reči

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