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2022, vol. 150, br. 9-10, str. 575-580
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Mikroanatomske karakteristike arterijske vaskularizacije prednje ukrštene veze
Microanatomical characteristics of arterial vascularization of the anterior cruciate ligament
aUniverzitet u Beogradu, Medicinski fakultet, Institut za anatomiju, Srbija bKlinički centar Srbije, Klinika za ortopedsku hirurgiju i traumatologiju, Beograd, Srbija cUniversity Clinical Centre of Republic of Srpska, Clinic of Plastic and Reconstructive Surgery, Banja Luka, Republic of Srpska, Bosnia and Herzegovina dAcademy of Applied Preschool Teaching and Health Studies, Kruševac-Ćuprija eUniverzitet u Prištini sa privremenim sedištem u Kosovskoj Mitrovici, Fakultet za sport i fizičko vaspitanje, Leposavić, Srbija fKlinički centar Niš, Klinika za urologiju, Srbija
e-adresa: milestrbacc@gmail.com
Projekat: Antioksidativna zaštita i potencijali za diferencijaciju i regeneraciju mezenhimalnih matičnih ćelija iz različitih tkiva tokom procesa starenja (MPNTR - 175061)
Sažetak
Uvod/Cilj Cilj studije je bio da se prouče imunohistohemijske karakteristike vaskularizacije prednje ukrštene veze (PUV), kao i kvantifikacija kapilarnih sudova u proksimalnom, srednjem i distalnom segmentu PUV. Drugi cilj ovog istraživanja bila je kvantifikacija i određivanje mernih karakteristika mastocita PUV. Metode Trideset humanih PUV poreklom od 30 osoba, dobijenih rutinskom obdukcijom, proučavani su pod mikroskopom posle imunohistohemijskih reakcija na endotelni marker CD34 krvnih sudova i mastocitnu triptazu prisutnih mastocita. Rezultati Srednja arterija kolena (a. media genus) u neposrednoj blizini PUV daje više malih arterija namenjenih vaskularizaciji samog ligamenta. Prosečan broj kapilara na kvadratnom milimetru površine polja preparata proksimalne trećine PUV iznosio je 1113,84 (959-1240), srednje trećine 1145,43 (924-1310), dok je kod distalne trećine PUV iznosio 1134,55 (889-1451). Prosečan broj mastocita po kvadratnom milimetru preparata PUV iznosio je 3,8. U perifernoj sinovijalnoj zoni PUV postojalo je prosečno 12,6 mastocita po kvadratnom milimetru. Prosečna površina triptaza pozitivnih mastocita bila je 124,7 mm2 . Prosečna vrednost kraćeg i dužeg prečnika ćelija bila je 11,2 × 15,0 mm. Zaključak Poređenje tri trećine PUV, proksimalne, srednje i distalne, pokazalo je da vrednosti kapilarne gustine u vezi nisu statistički značajne, p > 0,05; odnosno ne postoji statistički značajna razlika u broju mikrosudova po trećinama PUV. Krvni sudovi se uniformno raspoređuju bez obzira na posmatrani deo PUV.
Abstract
Introduction/Objective The aim of this study was to examine the immunohistochemical features of the vascularization of the anterior cruciate ligament (ACL), as well as the quantification of capillaries within the three segments of the ACL; proximal, middle and distal. The quantification and metric characteristics of mast cells of the ACL are the second goal of this research. Methods In total, 30 human ACL of 30 persons, obtained during routine autopsy, were examined under the microscope, following immunohistochemical reactions against CD34 of blood vessels and MastTrip of mast cells. Results The middle genicular artery close to the ACL gave off branches for the supply of ligament itself. Each field of mm2 contained an average number of 1113.84 (959-1240), microvessels in ACL proximal third, an average number of 1145.43 (924-1310) microvessels in ACL middle third, and an average number of 1134.55 (889-1451) microvessels in ACL distal third. An average number of mast cells of the ACL was 3.8 per mm2 . In the peripheral synovial zone of the ACL, we counted 12.6 mast cells per mm2 . An average area value of the mast cells was 124.7 mm2 , and an average value of shorter and longer axis of the mast cells was 11.2 × 15.0 mm. Conclusion There was no statistically significant differences between the average numbers of intraligamentous microvessels of the ACL thirds (p > 0.05), confirming and supporting our hypothesis of uniform distribution of blood supply within the ACL.
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