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Vojnosanitetski pregled
2019, vol. 76, br. 10, str. 998-1006
jezik rada: engleski
vrsta rada: izvorni naučni članak
doi:10.2298/VSP171002191S

Creative Commons License 4.0
Faktori povezani sa poštovanjem preporuka dobre kliničke prakse tokom bolničkog lečenja bolesnika sa prvom epizodom oboljenja iz shizofrenog spektra
Stašević Milenaa, Stašević-Karličić Ivanab, Divac Nevenac ORCID, Grgurević Anitad, Grbić Igorb
aClinic for Psychiatric Disorders "Dr Laza Lazarević", Belgrade
bClinic for Psychiatric Disorders "Dr Laza Lazarević", Belgrade + University of Pristina/Kosovska Mitrovica, Faculty of Medicine, Kosovska Mitrovica
cUniverzitet u Beogradu, Medicinski fakultet, Institut za farmakologiju, kliničku farmakologiju i toksikologiju
dUniverzitet u Beogradu, Medicinski fakultet, Institut za epidemiologiju

e-adresa: ivanastasevic73@gmail.com

Sažetak

Uvod/Cilj. Poštovanje smernica datih u vodičima dobre kliničke prakse tokom lečenja specifičnih poremećaja smatra se garancijom sprovođenja uniformne, na dokazima zasnovane kliničke prakse u psihijatriji. Cilj ovog rada bio je da se analizira usklađenost obrazaca propisivanja antipsihotičkih lekova sa preporukama dobre kliničke prakse u Srbiji i da se ostvari uvid u efekte koje je na propisivačku praksu u ovoj oblasti imalo donošenje Nacionalnog vodiča dobre kliničke prakse za dijagnostikovanje i lečenje shizofrenije. Metode. Neinterventna, opservaciona studija sprovedena je na Klinici za psihijatrijske bolesti "Dr Laza Lazarević" u Beogradu. Istraživanje je obuhvatilo uzastopni uzorak od 675 prethodno netretiranih bolesnika, lečenih hospitalno u periodu od 1. januara 2012. godine do 31. decembra 2015. godine, otpuštenih sa dijagnozom nekog od poremećaja iz shizofrenog spektra. Demografski podaci i podaci o kliničkim karakteristikama bolesnika, karakteristikama propisivača i propisanim antipsihoticima sakupljeni su retrospektivno, uvidom u medicinsku dokumentaciju bolesnika. Za analizu primarnih podataka korišćene su deskriptivne statističke metode i metode za testiranje statističkih hipoteza. Metoda logističke regresije korišćena je za identifikaciju faktora povezanih sa poštovanjem preporuka dobre kliničke prakse. Rezultati. Antipsihotičnom monoterapijom tretirano je 446 (66,1%) ispitanika. Nakon donošenja Nacionalnog vodiča dobre kliničke prakse za dijagnostikovanje i lečenje shizofrenije, propisivanje antipsihotične monoterapije antipsihoticima druge generacije bilo je značajno češće u odnosu na prethodni period (78,41% prema 63,5%; p < 0.001). Faktori nezavisno povezani sa poštovanjem preporuka dobre kliničke prakse su bili: starost ordinirajućeg lekara, starost i obrazovanje bolesnika i godina hospitalizacije. Zaključak. Nakon donošenja Nacionalnog vodiča dobre kliničke prakse za dijagnostikovanje i lečenje shizofrenije došlo je do značajnih, ali nedovoljnih promena u obrascima propisivanja antipsihotičke terapije tokom tretmana prve psihotične epizode u Srbiji.

Ključne reči

lekarska praksa, oblici; vodiči; srbija; shizofrenija; lečenje lekovima; antipsihotici

Reference
  Novododat članak: provera, normiranje i linkovanje referenci u toku.

 

Salomon JA, Vos T, Hogan DR, Gagnon M, Naghavi M, Mokdad A, et al. Common values in assessing health outcomes from disease and injury: disability weights measurement study for the Global Burden of Disease Study 2010. Lancet 2012; 380: 2129-43

 

Gelder GM, Andreas CN, Lopez-Ibor JJ, Geddes RJ. New Oxford Textbook of Psychiatry. 2nd ed. Oxford: Oxford University Press; 2009

 

Marshall M, Lewis S, Lockwood A, Drake R, Jones P, Croudace T. Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: a systematic review. Arch Gen Psychiatry 2005; 62(9): 975-83

 

Perkins DO, Gu H, Boteva K, Lieberman JA. Relationship between duration of untreated psychosis and outcome in firstepisode schizophrenia: a critical review and meta-analysis. Am J Psychiatry 2005; 162(10): 1785-804

 

Ito S, Nemoto T, Tsujino N, Ohmuro N, Matsumoto K, Matsuoka H, et al. Differential impacts of duration of untreated psychosis (DUP) on cognitive function in first-episode schizophrenia according to mode of onset. Eur Psychiatry 2015; 30(8): 995-1001

 

Cahn W, Hulshoff Pol HE, Lems EB, van Haren NE, Schnack HG, van der Linden JA, et al. Brain volume changes in first-episode schizophrenia: a 1-year follow-up study. Arch Gen Psychiatry 2002; 59(11): 1002-10

 

Roh D, Chang J, Yoon S, Kim C. Antipsychotic Prescribing Patterns in First-episode Schizophrenia: A Five-year Comparison. Clin Psychopharmacol Neurosci 2015; 13(3): 275-82

 

Lieberman JA, Alvir JM, Koreen A, Geisler S, Chakos M, Sheitman B, et al. Psychobiologic correlates of treatment response in schizophrenia. Neuropsychopharmacology 1996; 14(3 Suppl): 13S-21S

 

Lieberman JA, Koreen AR, Chakos M, Sheitman B, Woerner M, Alvir JM, et al. Factors influencing treatment response and outcome of first-episode schizophrenia: implications for understanding the pathophysiology of schizophrenia. J Clin Psychiatry 1996; 57 Suppl 9: 5-9

 

Birchwood M, Todd P, Jackson C. Early intervention in psychosis. The critical period hypothesis. Br J Psychiatry Suppl 1998; 172(33): 53-9

 

Crespo-Facorro B, Pelayo-Teran JM, Mayoral-van Son J. Current Data on and Clinical Insights into the Treatment of First Episode Nonaffective Psychosis: A Comprehensive Review. Neurol Ther 2016; 5(2): 105-30

 

Weiden PJ, Olfson M. Cost of relapse in schizophrenia. Schizophr Bull 1995; 21(3): 419-29

 

Abdel-Baki A, Ouellet-Plamondon C, Malla A. Pharmacotherapy challenges in patients with first-episode psychosis. J Affect Disord 2012; 138 Suppl: S3-14

 

Mayoral-van Son J, de la Foz VO, Martinez-Garcia O, Moreno T, Parrilla-Escobar M, Valdizan EM, et al. Clinical outcome after antipsychotic treatment discontinuation in functionally recovered first-episode nonaffective psychosis individuals: a 3-year naturalistic follow-up study. J Clin Psychiatry 2016; 77(4): 492-500

 

Lehman AF. Quality of care in mental health: the case of schizophrenia. Health Aff (Millwood) 1999; 18(5): 52-65

 

Lehman AF, Lieberman JA, Dixon LB, McGlashan TH, Miller AL, Perkins DO, et al. American Psychiatric Association; Steering Committee on Practice Guidelines. Practice guideline for the treatment of patients with schizophrenia, second edition. Am J Psychiatry 2004; 161(2 Suppl): 1-56

 

National Institute for health and Care Excellence (NICE). Clinical Guideline 178: Psychosis and Schizophrenia in Adults: Treatment and Management. London, UK; National Institute for health and Care Excellence; 2014

 

Kreyenbuhl J, Buchanan RW, Dickerson FB, Dixon LB. The Schizophrenia Patient Outcomes Research Team (PORT): Updated Treatment Recommendations 2009. Schizophr Bull 2010; 36(1): 94-103

 

Ministarstvo zdravlja Republike Srbije. Republička stručna komisija za izradu i implementaciju vodiča dobre kliničke prakse. Nacionalni vodič dobre kliničke prakse za dijagnostikovanje i lečenje shizofrenije. Belgrade; Ministarstvo zdravlja Republike Srbije; 2013. (Serbian)

 

World Health Organization. International classification of mental and behavioural disorders: Clinical description and diagnostic guidelines (ICD-10). Geneva: World Health Organization; 1992

 

Breitborde NJ, Srihari VH, Woods SW. Review of the operational definition for first-episode psychosis. Early Interv Psychiatry 2009; 3(4): 259-65

 

Register-Brown K, Hong LE. Reliability and validity of methods for measuring the duration of untreated psychosis: a quantitative review and meta-analysis. Schizophr Res 2014; 160(1-3): 20-6

 

Nielsen J, Le Quach P, Emborg C, Foldager L, Correll CU. 10-Year trends in the treatment and outcomes of patients with firstepisode schizophrenia. Acta Psychiatr Scand 2010; 122(5): 356-66

 

Pijnenborg GH, Timmerman ME, Derks EM, Fleischhacker WW, Kahn RS, Aleman A. Differential effects of antipsychotic drugs on insight in first episode schizophrenia: Data from the European First-Episode Schizophrenia Trial (EUFEST). European Neuropsychopharmacology 2015; 25(6): 808-16

 

Robinson DG, Schooler NR, John M, Correll CU, Marcy P, Addington J, et al. Medication prescription Practices in the Treatment of First-Episode Schizophrenia Spectrum Disorders: Data From the National RAISE-ETP Study. Am J Psychiatr 2015; 172(3): 237-48

 

Malaspina D. Schizophrenia: a neurodevelopmental or a neurodegenerative disorder. J Clin Psychiatry 2006; 67(8): e07

 

Marjanović D. Tranzicija mladih žena i muškaraca na tržištu rada Republike Srbije. Geneve: Međunarodna organizacija rada; 2016

 

Øhlenschlaeger J, Nordentoft M. Coercion in patients who at their first contact with the psychiatric services system were diagnosed within the schizophrenia-spectrum in Denmark. A register study. Nord J Psychiatry 2008; 62(1): 77-81

 

Large MM, Nielssen O. Violence in first-episode psychosis: a systematic review and meta-analysis. Schizophr Res 2011; 125(2-3): 209-20

 

Payne J, Malla A, Norman R, Windell D, Nicole B. Status of firstepisode psychosis patients presenting for routine care in a defined catchment area. Can J Psychiatry 2006; 51(1): 42-7

 

Souaiby L, Gaillard R, Krebs MO. Duration of untreated psychosis: A state-of-the-art review and critical analysis. Encephale 2016; 42(4): 361-6

 

Marić N, Đorđević A, Samardžić R, Jašović-Gašić M. Antipsihotici - ka jedinstvenom poređenju doziranja. Psihijat dan 2000; 32(2-3): 95-103

 

Penttilä M, Jääskeläinen E, Hirvonen N, Isohanni M, Miettunen J. Duration of untreated psychosis as predictor of long-term outcome in schizophrenia: systematic review and meta-analysis. Br J Psychiatry 2014; 205(2): 88-94

 

Bertelsen M, Jeppesen P, Petersen L, Thorup A, Øhlenschlaeger J, Le Quach P, et al. Course of illness in a sample of 265 patients with first-episode psychosis--five-year follow-up of the Danish OPUS trial. Schizophr Res 2009; 107(2-3): 173-8

 

Nielssen O, Yee N, Millard M, Large M. Comparison of First-Episode and Previously Treated Persons With Psychosis Found NGMI for a Violent Offense. Psychiatric Services 2011; 62(7): 759-64

 

Galderisi S, Mucci A, Bitter I, Libiger J, Bucci P, Fleischhacker WW, et al. Eufest Study Group. Persistent negative symptoms in first episode patients with schizophrenia: results from the European First Episode Schizophrenia Trial. Eur Neuropsychopharmacol 2013; 23(3): 196-204

 

Compton MT, Gordon TL, Goulding SM, Esterberg ML, Carter T, Leiner AS, et al. Patient-level predictors and clinical correlates of duration of untreated psychosis among hospitalized firstepisode patients. J Clin Psychiatry 2011; 72(2): 225-32

 

Marshall M, Husain N, Bork N, Chaudhry IB, Lester H, Everard L, et al. Impact of early intervention services on duration of untreated psychosis: Data from the National EDEN prospective cohort study. Schizophr Res 2014; 159(1): 1-6

 

Farooq S, Large M, Nielssen O, Waheed W. The relationship between the duration of untreated psychosis and outcome in low-and-middle income countries: A systematic review and meta analysis. Schizophr Res 2009; 109(1-3): 15-23

 

Zhang J, Gallego JA, Robinson DG, Malhotra AK, Kane JM, Correll CU. Efficacy and safety of individual second-generation vs. first-generation antipsychotics in first-episode psychosis: a systematic review and meta-analysis. Int J Neuropsychopharmacol 2013l; 16(6): 1205-18

 

Pérez-Iglesias R, Martínez-García O, Pardo-Garcia G, Amado JA, Garcia-Unzueta MT, Tabares-Seisdedos R, et al. Course of weight gain and metabolic abnormalities in first treated episode of psychosis: the first year is a critical period for development of cardiovascular risk factors. Int J Neuropsychopharmacol 2014; 17(1): 41-51

 

Tiihonen J, Haukka J, Taylor M, Haddad PM, Patel MX, Korhonen P. A Nationwide Cohort Study of Oral and Depot Antipsychotics After First Hospitalization for Schizophrenia. Am J Psychiatry 2011; 168(6): 603-9

 

Bioque M, Llerena A, Cabrera B, Mezquida G, Lobo A, González-Pinto A, et al. A Pharmacovigilance Study in First Episode of Psychosis: Psychopharmacological Interventions and Safety Profiles in the PEPs Project. Int J Neuropsychopharmacol 2016; 19(4): pii: pyv121

 

Tungaraza TE, Ahmed W, Chira C, Turner E, Mayaki S, Nandhra HS, et al. Prescribing pattern of clozapine and other antipsychotics for patients with first-episode psychosis: a crosssectional survey of early intervention teams. Ther Adv Psychopharmacol 2017; 7(3): 103-11

 

Divac N, Todorović Z, Stojanović R, Nešić Z, Jašović-Gašić M, Lečić-Tosevski D, et al. Utilization of psychiatric drugs in Serbia. Vojnosaniti Pregl 2009; 66(3): 233-7