Article metrics

  • citations in SCindeks: 0
  • citations in CrossRef:0
  • citations in Google Scholar:[=>]
  • visits in previous 30 days:0
  • full-text downloads in 30 days:0
article: 7 from 18  
Back back to result list
Vojnosanitetski pregled
2016, vol. 73, iss. 5, pp. 469-471
article language: English
document type: Short Communication
published on: 06/05/2016
doi: 10.2298/vsp141104035S
Creative Commons License 4.0
Increased accuracy of single photon emission computed tomography (SPECT) myocardial perfusion scintigraphy using iterative reconstruction of images
Clinical Centre Niš, Center of Nuclear Medicine



Background/Aim. Filtered back projection (FBP) is a common way of processing myocardial perfusion imaging (MPI) studies. There are artifacts in FBP which can cause false-positive results. Iterative reconstruction (IR) is developed to reduce false positive findings in MPI studies. The aim of this study was to evaluate the difference in the number of false positive findings in MPI studies, between FBP and IR processing. Methods. We examined 107 patients with angina pectoris with MPI and coronary angiography (CAG), 77 man and 30 woman, aged 32-82. MPI studies were processed with FBP and with IR. Positive finding at MPI was visualization of the perfusion defect. Positive finding at CAG was stenosis of coronary artery. Perfusion defect at MPI without coronary artery stenosis at CAG was considered like false positive. The results were statistically analyzed with bivariate correlation, and with one sample t-test. Results. There were 20.6% normal, and 79.4% pathologic findings at FBP, 30.8% normal and 69.2% pathologic with IR and 37.4% normal and 62.6% pathologic at CAG. FBP produced 19 false-positive findings, at IR 11 false positive findings. The correlation between FBP and CAG was 0.658 (p < 0.01) and between IR and CAG 0.784 (p < 0.01). The number of false positive findings at MPI with IR was significantly lower than at FBP (p < 0.01). Conclusion. Our study shows that IR processing MPI scintigraphy has less number of false positive findings, therefore it is our choice for processing MPI studies.



Angelides, S., Larcos, G., Hatton, R.L., Hutton, B.F., Choong, K.K.L. (2004) Improved tolerance to missing data in myocardial perfusion SPET using OSEM reconstruction. European Journal of Nuclear Medicine and Molecular Imaging, 31(6): 857-861
Bourque, J.M., Beller, G.A. (2011) Stress Myocardial Perfusion Imaging for Assessing Prognosis: An Update. JACC: Cardiovascular Imaging, 4(12): 1305-1319
Burrell, S., MacDonald, A. (2006) Artifacts and pitfalls in myocardial perfusion imaging. Journal of nuclear medicine technology, 34(4): 193-211; quiz 212-4
Henzlova, M., Cerqueira, M., Mahmarian, J., Yao, S. (2006) Stress protocols and tracers. Journal of Nuclear Cardiology, 13(6): e80-e90
Hesse, B., Tägil, K., Cuocolo, A., Anagnostopoulos, C., Bardiés, M., Bax, J., Bengel, F., Sokole, E. B., Davies, G., Dondi, M. (2005) EANM/ESC procedural guidelines for myocardial perfusion imaging in nuclear cardiology. European Journal of Nuclear Medicine and Molecular Imaging, 32(7): 855-897
Iftikhar, I., Koutelou, M., Mahmarian, J.J., Verani, M.S. (1996) Simultaneous perfusion tomography and radionuclide angiography during dobutamine stress. J Nucl Med, 37(8): 1306-10
Kitchens, C.T., Halkar, R.K., Alazraki, N.P., Galt, J. (2005) Difference in Filtered-Back Projection and Iterative Reconstruction in a Patient With Increased Splanchnic Uptake. Clinical Nuclear Medicine, 30(9): 623-624
Klocke, F.J. (2003) ACC/AHA/ASNC Guidelines for the Clinical Use of Cardiac Radionuclide Imaging--Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASNC Committee to Revise the 1995 Gu. Circulation, 108(11): 1404-1418
Nichols, K., Bacharach, S., Bergmann, S., Chen, J., Cullom, S., Dorbala, S., Ficaro, E., Galt, J., Greenconaway, D., Heller, G. (2007) Instrumentation quality assurance and performance. Journal of Nuclear Cardiology, 14(6): e61-e78
Sajid, H.S. (2007) Myocardial perfusion imaging protocols: Is there an ideal protocol. J Nucl Med Technol, 35(1): 3−9
Taillefer, R., DePuey, E., Udelson, J.E., Beller, G.A., Latour, Y., Reeves, F. (1997) Comparative Diagnostic Accuracy of Tl-201 and Tc-99m Sestamibi SPECT Imaging (Perfusion and ECG-Gated SPECT) in Detecting Coronary Artery Disease in Women. Journal of the American College of Cardiology, 29(1): 69-77
Verna, E., Ceriani, L., Giovanella, L., Binaghi, G., Garancini, S. (2000) 'False-positive' myocardial perfusion scintigraphy findings in patients with angiographically normal coronary arteries: insights from intravascular sonography studies. Journal of nuclear medicine, 41(12): 1935-40
Yan, Y., Zeng, G.L. (2008) Scatter and Blurring Compensation in Inhomogeneous Media Using a Postprocessing Method. International Journal of Biomedical Imaging, 2008: 1-11
Yester, M.V. (2006) SPECT image reconstruction. in: Henkin R.E. [ed.] Nuclear medicine, Philadelphia, PA: Mosby, 2nd ed, p. 185-95
Yussoff, S., Zakaria, A. (2010) Relationship between the optimum cut off frequency for Butterworth filter and lung-heart ratio in 99mTc myocardial SPECT. Iran J Radiat Res, 8(1); 17-24