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Medicinski pregled
2019, vol. 72, br. 9-10, str. 312-320
jezik rada: engleski
vrsta rada: stručni članak
objavljeno: 04/06/2020
doi: 10.2298/MPNS1910312S
Ispitivanje osetljivosti Klebsiella pneumoniae na antimikrobne lekove u periodu 2013-2017. godine
aUniverzitet u Novom Sadu, Medicinski fakultet + Klinički centar Vojvodine, Klinika za infektivne bolesti, Novi Sad
bGeneral Hospital "Dr. Radivoj Simonović", Sombor
cUniverzitet u Novom Sadu, Medicinski fakultet + Institute of Public Health of Vojvodina, Center of Virology, Novi Sad

e-adresa: sandra.stefan-mikic@mf.uns.ac.rs

Projekat

Praćenje zdravstvenog stanja divljači i uvođenje novih biotehnoloških postupaka u detekciji zaraznih i zoonoznih agenasa - analiza rizika za zdravlje ljudi, domaćih i divljih životinja i kontaminaciju životne sredine (MPNTR - 31084)

Sažetak

Uvod. Klebsiella pneumoniae je Gram-negativna bakterija, nepokretna sa izraženom kapsulom. Značajan je uzročnik oportunističkih infekcija naročito u bolničkim uslovima u kojima su najčešće prisutni multirezistentni sojevi. Cilj rada je utvrđivanje učestalosti bolničkih infekcija izazvanih bakterijom Klebsiella pneumoniae i prisustva rezistencije na antimikrobne lekove kod sojeva Klebsiella pneumoniae, izolovanih iz bolesničkog materijala rutinski uzorkovanog na Klinici za infektivne bolesti Kliničkog centra Vojvodine u periodu od 1. 1. 2013. do 31. 12. 2017. godine. Materijal i metode. Retrospektivna studija je obuhvatila 1.647 pacijenta sa dijagnozom infektivnih bolesti bakterijske etiologije lečenih na Klinici za infektivne bolesti Kliničkog centra Vojvodine. Analizom primoizolata izolovanih iz bolesničkog materijala (hemokulture, urinokulture, kulture likvora, bris rane/ dekubitusa i bris grla) pratili smo učestalost infekcija izazvanih bakterijom Klebsiella pneumoniae i njiovu osetljivost na antimikrobne lekove. Rezultati. Tokom petogodišnjeg ispitivanja izolovano je 93 primoizolata ove bakterije ̶ iz urinokultura 52/272 (19,1%), iz brisa grla 13/108 (12%), iz brisa rane/dekubitusa 12/120 (10,0%), iz hemokultura 13/285 (4,6%) i jedan izolat iz likvora 1/47 (2,1%). Izolati Klebsiella pneumoniae bili su najosetljiviji na tigeciklin i kolistin (100%). Tokom svih godina istraživanja prisutna je pojava rezistencije na karbapeneme, u zavisnosti od izolata i godine istraživanja, koja je iznosila i do 100%. Zaključak. Klebsiella pneumoniae je značajan uzročnik infekcija kod hospitalizovanih pacijenata. Njen izolati bili su osetljivi jedino na tigeciklin i kolistin (100%), a zabrinjavajuća je pojava rezistencije na karbapeneme i ostale ispitivane grupe antibiotika.

Ključne reči

Klebsiela pneumonije; infekcije Klebsielom; otpornost na lekove; antibiotici; bolnička infekcija

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