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2010, vol. 138, br. 7-8, str. 444-448
Da li bakterijska vaginoza i infekcija hlamidijom utiču na nivo citokina u serumu?
aKlinički centar Vojvodine, Klinika za ginekologiju i akušerstvo, Novi Sad
bKlinički centar Vojvodine, Klinika za infektivne bolesti, Novi Sad
cUniverzitet u Novom Sadu, Prirodno-matematički fakultet, Departman za hemiju
dUniverzitet u Novom Sadu, Medicinski fakultet, Katedra za farmaciju

e-adresambogavac@yahoo.com
Sažetak
Uvod. Srbija je zemlja s ekstremno niskom stopom prirodnog priraštaja i relativno velikim brojem prevremenih porođaja (8%). Zbog toga je pronalaženje dijagnostičkih metoda koje bi se mogle koristiti za predviđanje prevremenog porođaja izuzetno značajno. U ovom radu pokušali smo da otkrijemo da li bakterijska vaginoza i infekcija hlamidijom, preko aktiviranja sistemske mreže citokina, mogu biti uzroci prevremenog porođaja. Cilj rada. Cilj rada je bio da se odrede nivoi proinflamatornih citokina (IL-1β, IL-8, IFN-γ, IL-6 i TNF-α) u serumu trudnica sa simptomima prevremenog porođaja, a zatim napravi korelacija ovih parametara s prisustvom bakterijske vaginoze ili infekcije hlamidijom. Metode rada. U serumu 35 ispitanica, koje su svrstane u grupe prema postojanju bakterijske vaginoze i infekcije hlamidijom, nivoi proinflamatornih citokina su određeni komercijalnim ELISA testovima. Rezultati. Utvrđeno je statistički značajno povećanje nivoa IFN-γ kod trudnica s infekcijom hlamidijom, kao i povećanje nivoa IL-1β kod žena sa bakterijskom vaginozom. Nije bilo statistički značajnih razlika u nivoima TNF-α, IL-6 i IL-8 između ispitivanih grupa. Zaključak. Preliminarni rezultati dobijeni ovim istraživanjem ukazuju na mogućnost da ne samo intrauterina ili sistemska infekcija, već i bakterijska vaginoza i infekcija hlamidijom mogu dovesti do delimične aktivacije sistemske mreže citokina i doprineti prevremenom porođaju.
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O članku

jezik rada: engleski
vrsta rada: originalan članak
DOI: 10.2298/SARH1008444B
objavljen u SCIndeksu: 12.10.2010.