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2019, vol. 38, br. 4, str. 445-451
Tiol-disulfidna homeostaza, ishemijski modifikovani albumin i feroksidaza kao markeri oksidativnog stresa kod gojaznih žena sa insulinskom rezistencijom
aKaradeniz Technical University, Faculty of Medicine, Department of Family Medicine, Trabzon, Turkey
bKaradeniz Technical University, Faculty of Medicine, Department of Biochemistry, Trabzon, Turkey
cYildirim Beyazit University, Faculty of Medicine, Department of Biochemistry, Ankara, Turkey

e-adresadrealtunbas@yahoo.com
Sažetak
Uvod: Svrha ove studije bila je da se odredi nivo oksidativnog stresa vezan za plazma tiol/disulfid, nivo ishemijski modifikovanog albumina (IMA) i aktivnost feroksidaze kod gojaznih žena iz insulinski rezistentne i nerezistentne grupe u poređenju sa grupom žena sa prekomernom težinom. Metode: Uporedili smo plazma tiol/disulfid, nivoe IMA i aktivnost feroksidaze među ispitivanim grupama. Analizirali smo plazma tiol/disulfidnu homeostazu pomocu novorazvijene automatizovane metode merenja, IMA testom vezivanja albumin kobalta, a feroksidazu (ceruloplazmin) automatizovanom kolorimetrijskom metodom. Rezultati: Nije bilo znacajnih razlika između insulinski rezistentnih i nerezistentnih žena i gojaznih žena u smislu vrednosti koje se odnose na prirodni tiol, ukupni tiol, disulfid, odnos disulfid/prirodni tiol, disulfid/ukupni tiol ili prirodni tiol/ukupni tiol. Aktivnost feroksidaze bila je visa kod žena rezistentnih na insulin nego kod gojaznih žena koje nisu insulinski rezistentne, a veca je u ukupnom broju gojaznih nego kod ispitanica sa prekomernom težinom (p < 0,001 i p = 0,014, po ispitivanju). IMA je bio niži u grupi koja je rezistentna na insulin nego u grupama koje nisu rezistentne na insulin i grupi sa prekomernom težinom (p = 0,011 i p = 0,042). Zaključak: Znacajno vece povecanje aktivnosti feroksidaze kod gojaznih subjekata otpornih na insulin može odražavati njegovu ulogu kao pozitivnog proteina akutne faze. Ovi nalazi mogu biti povezani sa patogenezom bolesti. Promene u oksidativnom statusu javljaju se kod gojaznih 'ena i delimicno kod ispitanica sa prekomernom težinom. Feroksidazna aktivnost ceruloplazmina igra kljucnu ulogu u homeostazi gvožđa i smanjuje oksidativni stres smanjenjem štetnih efekata gvožđa.
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O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
PMC ID: PMC6708298
DOI: 10.2478/jomb-2019-0015
objavljen u SCIndeksu: 06.02.2020.