Chronic inflammation and lipid profile parameters in obese subjects with normal and disturbed glucose metabolism

Pejin, Radoslav; Stokić, Edita; Tanackov, Ilija; Popović, Đorđe; Bjelica, Artur; Jovanović, Aleksandar

doi:10.2298/SARH180710017P

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Srpski arhiv za celokupno lekarstvo

2019, vol. 147, br. 3-4, str. 173-180

Hronična inflamacija i parametri lipidnog statusa kod gojaznih osoba sa normalnim i poremećenim metabolizmom glukoze

Pejin Radoslav^a, Stokić Edita^a, Tanackov Ilija^b, Popović Đorđe^a, Bjelica Artur^c, Jovanović Aleksandar^d

^aKlinički centar Vojvodine, Klinika za endokrinologiju, dijabetes i bolesti metabolizma, Novi Sad + Univerzitet u Novom Sadu, Medicinski fakultet
^bUniverzitet u Novom Sadu, Fakultet tehničkih nauka
^cKlinički centar Vojvodine, Klinika za ginekologiju i akušerstvo, Novi Sad + Univerzitet u Novom Sadu, Medicinski fakultet
^dKlinički centar Vojvodine, Klinika za neurologiju, Novi Sad + Univerzitet u Novom Sadu, Medicinski fakultet

e-adresa: radoslavpejin@gmail.com

Ključne reči: C-reaktivni protein; lipoprotein (a); trigliceridi; metformin, gojaznost; dijabetes tipa 2

Sažetak

Uvod/Cilj U različitim stanjima sa povišenim stepenom hronične inflamacije, kao što su gojaznost i dijabetes, rane promene u metabolizmu lipida mogu predstavljati svrsishodan adaptivni odgovor u cilju smanjivanja inflamatorne reakcije u organizmu. Cilj istraživanja je bio da se ispita uticaj gojaznosti i glikozne regulacije na odnos hronične inflamacije i lipidskih parametara metabolizma. Metode Studija se sastojala od četiri grupe (n = 30 za svaku grupu): gojazne osobe sa poremećenim metabolizmom glukoze (subjekti sa novodijagnostikovanim dijabetesom melitusom tipa 2 (DMT2)) pre i u toku metforminske terapije, gojazne osobe sa normalnom tolerancijom glukoze (NTG) i kontrolne grupe zdravih subjekata normalne telesne mase. Odgovarajuća antropometrijska merenja i laboratorijska testiranja su sprovedena kod svih učesnika. Rezultati Između grupa gojaznih bolesnika povezanost nivoa visoko osetljivog C-reaktivnog proteina (hsCRP) sa nivoom triglicerida i lipoproteina (a) (Lp(a)) naročito je izražena u grupi osoba sa DMT2 pre početka terapije metforminom. U ovoj grupi nivo inflamacije je bio najviši i korelacioni koeficijenti triglicerida (r = 0,21 vs. r = -0,36; p = 0,0172) i Lp (a) (r = -0,17 vs. r = 0,36, p = 0,0324) sa hsCRP se statistički značajno razlikuju u poređenju sa grupom gojaznih. Linearne korelacije hsCRP sa trigliceridima (r = 0,21 vs. r = 0,38, p = 0,2449) i Lp(a) (r = -0,17 vs. r = -0,27, p = 0,3562) u grupama gojaznih osoba sa NTG i osoba sa DMT2 tokom terapije nisu se statistički značajno razlikovale. Tretman sa metforminom je promenio odnos linernih korelacija hsCRP sa trigliceridima i Lp(a) slično onome kod gojaznih osoba sa NTG. Zaključak Kod ispitanika sa novodijagnostikovanim DMT2, koji imaju najviši nivo zapaljenja, povećanje nivoa triglicerida može predstavljati deo antiinflamatornog odgovora, dok hipotetički molekuli Lp(a) mogu igrati ulogu u smanjenju povišenih nivoa inflamacije.

Abstract

Introduction/Objective In different states of increased chronic inflammation, like obesity and diabetes, early changes in lipid metabolism could represent an adaptive response aimed at diminishing the elevated inflammatory reaction. The aim of study was to investigate the impact of glucose tolerance status on relationship between chronic inflammation and lipid metabolism parameters. Methods the study consisted of four groups (n = 30 for each group): obese individuals with disturbed glucose metabolism (subjects with newly diagnosed type 2 diabetes (T2DM)) before and after metformin treatment initiation, obese subjects with normal glucose tolerance (NGT) and a control group of healthy normal weight subjects. Appropriate anthropometric measurements and laboratory tests were carried out in all participants. Results Among the subgroup of obese subjects, the association of highly sensitive C reactive protein (hsCRP) with triglycerides and lipoprotein (a) (Lp(a)) was especially pronounced in the group of T2DM subjects before treatment initiation. In this group, the level of inflammation was the highest and correlation coefficients of triglycerides and Lp(a) with hsCRP were significantly different compared with the group of obese without diabetes (r = 0.21 vs. r =-0.36; p = 0.0172) for triglycerides and (r =-0.17 vs. r = 0.36, p = 0.0324) for Lp(a). Correlations of hsCRP with triglycerides and Lp(a) in groups of NGT obese subjects and T2DM subjects after treatment initiation did not differ significantly. Treatment with metformin changed the relationship of hsCRP with triglycerides and Lp(a) to the one which is similar to the relationship observed in obese NGT subjects (r = 0.21 vs. r = 0.38; p = 0.2449) for triglycerides and (r =-0.17 vs. r =-0.27, p = 0.3562) for Lp(a). Conclusion In subjects with newly diagnosed T2DM, who have the highest level of inflammation, it is probable that the increase in triglycerides is a part of the anti-inflammatory response, whereas Lp(a) is probably produced and used in the reduction of elevated inflammation.

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O članku

jezik rada: engleski
vrsta rada: originalan članak
DOI: 10.2298/SARH180710017P
objavljen u SCIndeksu: 07.07.2019.

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