Metrika

  • citati u SCIndeksu: 0
  • citati u CrossRef-u:0
  • citati u Google Scholaru:[]
  • posete u poslednjih 30 dana:3
  • preuzimanja u poslednjih 30 dana:0

Sadržaj

članak: 9 od 53  
Back povratak na rezultate
2019, vol. 76, br. 7, str. 703-709
Udruženost vaskularnih i inflamatornih markera metaboličkih poremećaja kod žena sa sindromom policističnih jajnika
aSs Cyril and Methodius University of Skopje, Faculty of Medicine, University Clinic of Obstetrics and Gynecology, Skopje, Republic of North Macedonia
bSs Cyril and Methodius University of Skopje, Faculty of Medicine, Institute of Epidemiology and Biostatistics with Medical Informatics, Skopje, Republic of North Macedonia

e-adresaaleksandraatanasova@yahoo.com
Sažetak
Uvod/Cilj. Prevalencija metaboličkih poremećaja, gojaznosti i insulinske rezistencije kod žena sa sindromom policističnih jajnika (PCOS) prisutna je u ranim fazama života i postavlja ovu grupu u rizik za rani razvoj kardiovaskularnih bolesti. Hiperhomocisteinemija i povecana aktivnost C-reaktivnog protein (CRP) imaju uticaj na promociju ateroskleroze. Cilj ove studije je bio da se proceni da li su vrednosti visoko senzitivnog (hs-CRP) i homocisteina (Hcy) povišene kod PCOS i da se razjasne njihove moguće veze sa gojaznošću, insulinskom rezistencijom i metaboličkim promenama. Metode. Serumski nivoi hs-CRP i plazma nivoi Hcy su bili analizirani kod 73 žene sa PCOS i 43 zdrave žene, zajedno sa kliničkim, antropometrijskim i hormonskim parametrima. Rezultati. Srednje vrednosti indeksa telesne mase (BMI), obima struka, odnosa kukova i struka kao i koncentracija luteinizirajuceg hormona, testosterona, androstenediona, indeksa slobodnog androgena, insulina na gladno, homeostatskog modela za procenu insulinske rezistencije (HOMA-IR), i Hcy su bili značajno povećane kod žena sa PCOS u poređenju sa zdravim ženama istih godina. Ustanovljena je pozitivna korelacija između hs-CRP i BMI, holesterola, insulina, triglicerida (p < 0,001) i značajna negativna korelacija sa luteinirirajućim hormonom (LH), vezujućim globulinom polnih hormona (SHGB), HOMAIR, HDL-C (p < 0,001). Koncentracija Hcy imala je značajnu negativnu korelaciju sa HDL-C (p < 0,05). Zaključak. Istraživanjem je ustanovljena povećana srednja koncentracija Hcy i hs-CRP kod žena sa PCOS. Naši rezultati ukazuju na opravdanost upotrebe ovih biomarkera u proceni potencijalnog rizika za kardiovaskularne bolesti i rane prognoze i implikacija lečenja.
Reference
Baldani-Pavicic, D., Skrgatic, L., Cerne-Ziva, J., Oguic-Kralik, S., Gersak, B.M., Gersak, K.M. (2015) Association between serum levels and pentanucleotide polymorphism in the sex hormone binding globulin gene and cardiovascular risk factors in females with polycystic ovary syndrome. Molecular Medicine Reports, 11(5): 3941-3947
Bickerton, A.S., Clark, N., Meeking, D., Shaw, K.M., Crook, M., Lumb, P., et al. (2005) Cardiovascular risk in women with polycystic ovarian syndrome (PCOS). Journal of Clinical Pathology, 58(2): 151-154
Celik, C., Bastu, E., Abali, R., Alpsoy, S., Guzel, E.C., Aydemir, B., Yeh, J. (2013) The relationship between copper, homocysteine and early vascular disease in lean women with polycystic ovary syndrome. Gynecological Endocrinology, 29(5): 488-491
Cho, L.W., Jayagopal, V., Kilpatrick, E.S., Atkin, S.L. (2005) The Biological Variation of C-Reactive Protein in Polycystic Ovarian Syndrome. Clinical Chemistry, 51(10): 1905-1907
Coelho, M., Oliveira, T., Fernandes, R. (2013) State of the art paper Biochemistry of adipose tissue: An endocrine organ. Archives of Medical Science, 2(2): 191-200
Conway, G., Dewailly, D., Diamanti-Kandarakis, E., Escobar-Morreale, H.F., Franks, S., Gambineri, A., Kelestimur, F., Macut, D., Micic, D., Pasquali, R., Pfeifer, M., Pignatelli, D., Pugeat, M. (2014) The polycystic ovary syndrome: A position statement from the European Society of Endocrinology. European Journal of Endocrinology, 171(4): P1-P29
Deboer, M.D. (2013) Obesity, systemic inflammation, and increased risk for cardiovascular disease and diabetes among adolescents: A need for screening tools to target interventions. Nutrition, 29(2): 379-386
Deligeoroglou, E., Vrachnis, N., Athanasopoulos, N., Iliodromiti, Z., Sifakis, S., Iliodromiti, S., Siristatidis, C., Creatsas, G. (2012) Mediators of chronic inflammation in polycystic ovarian syndrome. Gynecological Endocrinology, 28(12): 974-978
Diamanti-Kandarakis, E., Dunaif, A. (2012) Insulin Resistance and the Polycystic Ovary Syndrome Revisited: An Update on Mechanisms and Implications. Endocrine Reviews, 33(6): 981-1030
Escobar-Morreale, H.F., Luque-Ramírez, M., González, F. (2011) Circulating inflammatory markers in polycystic ovary syndrome: A systematic review and meta-analysis. Fertility and Sterility, 95(3): 1048-1058.e2
Ezeh, U., Yildiz, B.O., Azziz, R. (2013) Referral Bias in Defining the Phenotype and Prevalence of Obesity in Polycystic Ovary Syndrome. Journal of Clinical Endocrinology & Metabolism, 98(6): E1088-E1096
González, F. (2012) Inflammation in Polycystic Ovary Syndrome: Underpinning of insulin resistance and ovarian dysfunction. Steroids, 77(4): 300-305
Güdücü, N., Işçi, H., Yiğiter, A.B., Dünder, I. (2012) C-reactive protein and lipoprotein-a as markers of coronary heart disease in polycystic ovary syndrome. J Turk Ger Gynecol Assoc, 13(4): 227-259
Guleria, A.K., Syal, S.K., Kapoor, A., Kumar, S., Tiwari, P., Dabadghao, P. (2014) Cardiovascular disease risk in young Indian women with polycystic ovary syndrome. Gynecological Endocrinology, 30(1): 26-29
Guzelmeric, K., Alkan, N., Pirimoglu, M., Unal, O., Turan, C. (2007) Chronic inflammation and elevated homocysteine levels are associated with increased body mass index in women with polycystic ovary syndrome. Gynecological Endocrinology, 23(9): 505-510
Hart, R., Doherty, D.A. (2015) The Potential Implications of a PCOS Diagnosis on a Woman's Long-Term Health Using Data Linkage. Journal of Clinical Endocrinology & Metabolism, 100(3): 911-919
Jacques, P.F., Bostom, A.G., Wilson, P.W., Rich, S., Rosenberg, I.H., Selhub, J. (2001) Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort. American Journal of Clinical Nutrition, 73(3): 613-621
Kilic-Okman, T., Guldiken, S., Kucuk, M. (2004) Relationship between Homocysteine and Insulin Resistance in Women with Polycystic Ovary Syndrome. Endocrine Journal, 51(5): 505-508
Koenig, W. (2013) High-sensitivity C-reactive protein and atherosclerotic disease: From improved risk prediction to risk-guided therapy. International Journal of Cardiology, 168(6): 5126-5134
Kurt, R.K., Okyay, A.G., Hakverdi, A.U., Gungoren, A., Dolapcioglu, K.S., Karateke, A., et al. (2014) The effect of obesity on inflammatory markers in patients with PCOS: A BMI-matched case-control study. Arch Gynecol Obstet, 2(290): 315-324
March, W. A., Moore, V. M., Willson, K. J., Phillips, D. I.W., Norman, R. J., Davies, M. J. (2010) The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria. Human Reproduction, 25(2): 544-551
March, W.A., Moore, V.M., Willson, K.J., Phillips, D.I.W., Norman, R.J., Davies, M.J. (2010) The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria. Human Reproduction, 25(2): 544-551
Morgante, G., La, M.A., Setacci, F., Setacci, C., Petraglia, F., de Leo, V. (2002) The Cardiovascular Risk Factor Homocysteine Is Not Elevated in Young Women with Hyperandrogenism or Hypoestrogenism. Gynecologic and Obstetric Investigation, 53(4): 200-203
Obersby, D., Chappell, D.C., Dunnett, A., Tsiami, A.A. (2013) Plasma total homocysteine status of vegetarians compared with omnivores: A systematic review and meta-analysis. British Journal of Nutrition, 109(5): 785-794
Sathyapalan, T., Atkin, S.L. (2010) Mediators of Inflammation in Polycystic Ovary Syndrome in Relation to Adiposity. Mediators of Inflammation, 2010: 1-5
Schachter, M., Raziel, A., Friedler, S., Strassburger, D., Bern, O., Ron-El, R. (2003) Insulin resistance in patients with polycystic ovary syndrome is associated with elevated plasma homocysteine. Human Reproduction, 18(4): 721-727
Steed, M.M., Tyagi, S.C. (2011) Mechanisms of cardiovascular remodeling in hyperhomocysteinemia. Antioxid Redox Signal, 15(7): 1927-1970
Teede, H., Deeks, A., Moran, L. (2010) Polycystic ovary syndrome: A complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan. BMC Medicine, 8(1): 41-41
Toulis, K.A., Goulis, D.G., Mintziori, G., Kintiraki, E., Eukarpidis, E., Mouratoglou, S.A., Pavlaki, A., Stergianos, S., Poulasouchidou, M., Tzellos, T.G., Makedos, A. (2011) Meta-analysis of cardiovascular disease risk markers in women with polycystic ovary syndrome. Human Reproduction Update, 17(6): 741-760
Wake, D.J., Strand, M., Rask, E., Westerbacka, J., Livingstone, D.E.W., Soderberg, S., Andrew, R., Yki-Jarvinen, H., Olsson, T., Walker, B.R. (2007) Intra-adipose sex steroid metabolism and body fat distribution in idiopathic human obesity. Clin Endocrinol (Oxford), 66(3): 440-446
Wald, D.S., Law, M., Joan, M.K. (2002) Homocysteine and cardiovascular disease: Evidence on causality from a meta-analysis. BMJ, 325(7374): 1202-1206
Wijeyaratne, C.N., Dilini, U.S.A., Balen, A.H. (2013) Ethnic-specific polycystic ovary syndrome: Epidemiology, significance and implications. Expert Review of Endocrinology & Metabolism, 8(1): 71-79
Wu, Y., Zhang, J., Wen, Y., Wang, H., Zhang, M., Cianflone, K. (2009) Increased acylation-stimulating protein, C-reactive protein, and lipid levels in young women with polycystic ovary syndrome. Fertility and Sterility, 91(1): 213-219
 

O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
DOI: 10.2298/VSP170504158B
objavljen u SCIndeksu: 29.07.2019.
metod recenzije: dvostruko anoniman
Creative Commons License 4.0