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Acta Facultatis Medicae Naissensis
2022, vol. 39, br. 4, str. 433-442
Da li nivoi nukleolina i nukleofosmina mogu biti prognostički indikatori karcinoma malih ćelija pluća?
Akın Güla, Esbah Onurb, Eröz Recepc
aUniverzitet u Duzdžeu, Medicinski fakultet, Departman za internu medicinu, Duzdže, Turska
bUniverzitet u Duzdžeu, Medicinski fakultet, Departman za onkologiju, Duzdže, Turska
cUniverzitet u Aksaraju, Medicinski fakultet, Departman za medicinsku genetiku, Aksaraj, Turska

e-adresa: gulakindr@gmail.com
Ključne reči: karcinom; nukleolin; nukleofosmin
Sažetak
Cilj. Karcinom pluća je vodeći uzrok smrtnosti širom sveta. U ovoj studiji ispitivana je upotreba nivoa nukleolina (NCL) i nukleofosmina (NPM1) u serumu, kao markera kod uspostavljanja dijagnoze, prognoze i procene odgovora na lečenje karcinoma pluća. Bolesnici i Metode. Korišćenjem ELISA metode ispitivani su nivoi nukleolina i nukleofosmina u uzorcima seruma, uzetim pre hemioterapije i nakon tri četiri ciklusa hemioterapije, kod kontrolne grupe i bolesnika kod kojih je dijagnostikovan karcinom pluća. Rezultati. Nivoi serumskog nukleolina i nukleofosmina bili su viši kod bolesnika nego u kontrolnoj grupi (p = 0,085 za NCL, p = 0,000 za NPM1). Nivoi NCL i NPM1 po histološkom tipu bili su značajno povišeni kod adenokarcinoma u poređenju sa karcinomom skvamoznih ćelija (p < 0,05, kod oba). U pogledu odgovora na hemoterapijske agense zabeležena je statistički beznačajna razlika između vrednosti pre i posle hemioterapije (p > 0,05 za obe vrednosti). Zaključak. Utvrđeno je to da su visoki nivoi NCL i NPM1 u serumu u korelaciji sa lošom prognozom, lošim odgovorom na terapiju i niskom stopom preživljavanja. Može se zaključiti da se nivoi NCL i NPM1 kod karcinoma pluća mogu koristiti kao dijagnostički i prognostički markeri bolesti.
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O članku

jezik rada: engleski
vrsta rada: originalan članak
DOI: 10.5937/afmnai39-35741
primljen: 04.01.2022.
revidiran: 29.07.2022.
prihvaćen: 12.10.2022.
objavljen onlajn: 12.12.2022.
objavljen u SCIndeksu: 28.01.2023.
metod recenzije: dvostruko anoniman
Creative Commons License 4.0

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