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2021, vol. 37, br. 84, str. 2225-2225
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Pušenje i konzumiranje alkohola kao faktori rizika kod 112 onkoloških bolesnika sa dijagnozom bisfosfonatne osteonekroze vilica
Smoking and alcohol consumption as risk factors in 112 oncology patients diagnosed with bisphosphonate-associated osteonecrosis of the jaw
aMedicinski univerzitet Plovdiv, Fakultet za javno zdravlje, Departman za epidemiologiju i vanredne situacije u medicini, Plovdiv, Bugarska
bMedicinski univerzitet Plovdiv, Fakultet za javno zdravlje, Departman za socijalnu medicinu i javno zdravlje, Plovdiv, Bugarska
cUniverzitet u Plovdivu, Klinika za maksilofacijalnu hirurgiju, Univerzitetska bolnica "Sveti Georgije", Plovdiv, Bugarska
Projekat: The paper was supported by the Ministry of Education and Science, Republic of Bulgaria (National program "Young scientists and postdoctoral students").
Sažetak
Uvod: Osteonekroza vilica udružena sa bisfosfonatima (OVUB) je komplikacija od velikog medicinskog značaja. Neki od najkontroverznijih apsekata o kojima se najviše diskutovalo jesu faktori rizika, od kojih su neki povezani sa pušenjem i konzumacijom alkohola kod pacijenata kod kojih se osteonekroza pojavila.. Cilj: Proceniti koliki je rizik od nastajanja OVUB oboljenja kod onkoloških pacijenata sa rizičnim zdravstvenim navikama. Materijal i metode: Sprovedena je Prospektivna epidemiološka studija, je obuhvatila 112 pacijenata sa dijagnostifikovanom osteonekrozom vilice udružene sa bisfosfonatima, sprovedena je na Klinici za maksilofacijalnu hirurgiju Univerzitetske bolnice "Sveti Georgije" u Plovdivu, u Bugarskoj, u periodu od 2016. i 2017. godinu, na osnovu anamneze, kliničkog pregleda i pregleda bolničke dokumentacije. Za statističku analizu korišćen je SPSS program v.24, sa nivoom značajnosti postavljenim na p < 0,05. Rezultati: Preko 2/3 pacijenata bili su pušači (40,18%) ili bivši pušači (25,00%), što ih povezuje sa faktorom rizika-pušenjem. U vreme studije, pušači koji su pušili između 1 cigarete i 9 cigareta i između 10 i 19 cigareta dnevno imali su jednak relativni udeo od 44,22%. Više od polovine pacijenata koji su pušili starosti su između 20 i 39 godina, odosno bili su sa visokom prosečnom starošću. Većina ispitivanih pacijenata konzumirala je alkohol, najčešće jednom nedeljno ili vikendom (28,57%) ili samo povremeno (26,79%), a 24,11% unosilo je alkohol nekoliko puta nedeljno. Skoro 2/3 ispitanika konzumiralo je piće i sa niskim i sa visokim sadržajem alkohola. Zaključak: Najveći broj pacijenata bili su pušači/bivši pušači i povremeni konzumenti alkohola, što ih ukazuje da su pušenje i alkohol potencijalni faktori rizika za razvoj bisfosfonatne osteonekroze vilica.
Abstract
Background: Bisphosphonate-associated osteonecrosis of the jaws (BAONJ) is a complication of great medical importance. Some of the most discussed and controversial aspects are the risk factors, some of which are related to patients' smoking and alcohol consumption. The Aim: To study cancer patients with BAONJ and determine their participation in the mentioned above risky health-related habits. Material and methods: A prospective epidemiological study of 112 patients diagnosed with bisphosphonate-associated osteonecrosis of the jaw in 2016 and 2017 was conducted at the Clinic of Maxillofacial surgery of University hospital "St. George", Plovdiv, Bulgaria, based on anamnesis, clinical examination, and hospital documentation. SPSS Statistics v.24 was used for statistical analysis, at a significance level p<0.05. Results: Over 2/3 of the patients were smokers (40.18%) or ex-smokers (25.00%), which linked them with the risk factor of smoking. At the time of the study, patients smoking between 1 and 9 and between 10 and 19 cigarettes a day had equal relative shares of 44.22%. More than half of the patients smoked from the age of 20-39, which we explain by the high average age. The majority of patients studied consumed alcohol, most often once a week or on weekends (28.57%) or only on occasions (26.79%), followed by 24.11% who used alcohol several times per week. Nearly 2/3 drink drinks with both low and high alcohol content. Conclusion: The highest proportion of patients are smokers / ex-smokers and consume alcoholic beverages occasionally, which links them to these risk potential factors.
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