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Srpski arhiv za celokupno lekarstvo
2020, vol. 148, br. 1-2, str. 48-51
jezik rada: engleski
vrsta rada: originalan članak
doi:10.2298/SARH180904083R
Benigna prolazna hiperfosfatazemija kod dece
aSrpsko lekarsko društvo, Akademija medicinskih nauka, Beograd
bUniverzitetska dečja klinika, Beograd + Univerzitet u Beogradu, Medicinski fakultet, Beograd
cUniverzitet u Beogradu, Medicinski fakultet, Univerzitetska dečija klinika
dMedicinski centar "Valjevo", Valjevo
eOpšta bolnica "Novi Pazar", Novi Pazar
fUniverzitet u Banjoj Luci, Medicinski fakultet, Banja Luka, Republika Srpska, Bosna i Hercegovina

e-adresa: n.radlovic@botel.net

Sažetak

Uvod/Cilj Benigna prolazna hiperfosfatazemija (BPHF) predstavlja patogenetski nedovoljno jasan klinički entitet, koji se pretežno viđa kod odojčadi i male dece. Cilj rada je da se iznesu naša iskustva vezana za uzrast javljanja, okolnosti otkrivanja i dužinu trajanja BPHF kod dece. Metode Rad je realizovan na uzorku od 18 dece - devet dečaka i devet devojčica, uzrasta 10-42 (21,06 ± 9,35) meseca sa BPHF. Dijagnoza BPHF je bazirana na odsustvu koštanih i hepatobilijarnih oboljenja, kao i njenom spontanom iščezavanju tokom nekoliko narednih meseci. Rezultati Jedno dete je bilo u prvoj godini, 13 u drugoj, tri u trećoj i jedno u četvrtoj. Izolovana visoka aktivnost serumske alkalne fosfataze, koja je bila 2,04-21,9 (8,05 ± 5,31) puta iznad gornje referentne vrednosti za odgovarajuću starost, kod 14 slučajeva je nađena u okviru akutne dijareje i kod četiri slučaja sa akutnim rinofaringitisom, od čega kod dva sa komplikovanim otitisnim medijem. Uzrok dijareje u šest slučajeva bio je rotavirus, u dva slučaja kampilobakterija i u jednom slučaju adenovirus, a uzrok otitisnog medija u jednom slučaju bile su streptokoke pneumonije, dok kod ostalih etiološki činilac infekcije nije identifikovan. Spontana normalizacija serumske aktivnosti alkalne fosfataze registrovana je između jednog i tri meseca. Zaključak BPHF predstavlja bezazlen biohemijski poremećaj koji se spontano povlači unutar tri meseca posle inicijalne opservacije. Otkriva se slučajno kao rutinski laboratorijski nalaz najčešće u sklopu tretmana akutnih gastrointestinalnih i respiratornih infekcija.

Ključne reči

benigna prolazna hiperfosfatazemija; dijagnostika; deca

Reference

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