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Vojnosanitetski pregled
2014, vol. 71, br. 7, str. 667-672
jezik rada: engleski
vrsta rada: izvorni naučni članak
doi:10.2298/VSP120524014V
Uticaj vodenog rastvora steviozida na farmakološka svojstva nekih kardioaktivnih lekova
aDepartment of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, Novi Sad
bInstitute of Occupational Health, Faculty of Medicine, Novi Sad
cKlinički centar Novi Sad

e-adresa: borismed@gmail.com

Projekat

Interakcije ksenobiotika i uticaj na sisteme u biomedicini (MPNTR - 41012)
Secretariat for Science and Technological Development, Autonomous Province of Vojvodina, project No 114-451 -245 8/2011

Sažetak

Uvod/Cilj. Steviozid je glikozid za koji se pretpostavlja da poseduje niz farmakodinamskih efekata kao što su antiinfektivni, hipoglikemijski, kao i uticaj na kardiovaskularni sistem. Cilj rada bio je da se utvrdi uticaj pretretmana pacova vodenim rastvorom steviozida na farmakološko dejstvo adrenalina, metoprolola i verapamila. Metode. Pacovi su tretirani (intraperitonealno 200 mg/kg/dan) vodenim rastvorom steviozida ili fiziološkim rastvorom pet dana, nakon čega su anestezirani uretanom i urađen im je prvi EKG. U preparisanu venu jugularis infuzionom pumpom potom je primenjivan adrenalin (0,1 mg/mL), verapamil (2,5 mg/mL) ili metoprolol (1 mg/mL). Kontrolne životinje, pretretirane fiziološkim rastvorom, osim navedenih lekova, primale su i rastvor steviozida (200 mg/mL) preko infuzione pumpe. Sve vreme dok su lekovi davani u jugularnu venu, sniman je EKG. Rezultati. Infuzija steviozida nije uzrokovala značajne promene EKG-a, čak ni pri dozi koja je prelazila 1 600 mg/kg. U kontrolnoj grupi doza adrenalina od 0,07 ± 0,02 mg/kg smanjila je srčanu aktivnost, dok je kod pacova prethodno tretiranih steviozidom taj efekat postignut pri znatno višoj dozi (0,13 ± 0,03 mg/kg). Kod pacova koji su prethodno tretirani steviozidom doze verapamila potrebne za izazivanje smanjenja srčane aktivnosti bile su značajno niže u odnosu na kontrolu. Prethodni tretman steviozidom nije izazvao značajne promene parametara koji su praćeni na EKG-u tokom infuzije metoprolola. Zaključak. Rezultati pokazuju da kod pacova pretretiranih steviozidom dolazi do promena dejstva adrenalina i verapamila na frekvenciju srca.

Ključne reči

Reference

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