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Efekat oralne konzumacije ekstrakta lavande (Lavandula) na prehipertenziju kod penzionera smeštenih u gerontološkim centrima - randomizovana klinička studija
Effect of the oral consumption of lavender extract (lavandula) on prehypertension in the retirees of retirement centers: A randomized clinical trial
aSabzevar University of Medical Sciences, School of Nursing and Midwifery, Student Research Committee, Sabzevar, Iran bSabzevar University of Medical Sciences, School of Medicine, Department of Traditional Medicine, Sabzevar, Iran cSabzevar University of Medical Sciences, Nursing and Midwifery School, Iranian Research Center on Healthy Aging, Department of Nursing, Sabzevar, Iran dUniversity of Medical Sciences, School of Health, Department of Epidemiology and Biostatistics, Student Research Committee, Mashhad, Iran
e-adresa: mostafarad633@yahoo.com
Projekat: This work was financially supported by a project grant from Sabzevar University of Medical Sciences (Project number # 98135).
Sažetak
Uvod/Ciljevi. Hipertenzija je čest poremećaj kod starije populacije koji se može sprečiti lekovitim biljem. Cilj ove studije bila je procena efekta ekstrakta lavande na prehipertenziju kod populacije penzionera. Metode. Ova trostruko slepa klinička studija obuhvatila je 60 penzionera muškog i ženskog pola, koji su bili podeljeni u dve grupe, primenom tehnike permutovanog bloka: grupu koja je primala ekstrakt lavande i placebo grupu. Ekstrakt lavande (poreklom iz cveta biljke) i placebo primenjivani su dva puta dnevno (3 gr je ekvivalent 3 cc) u trajanju od dve nedelje. Krvni pritisak meren je pre primene, nedelju dana i dve nedelje nakon primene leka, kao i nedelju dana nakon prekida davanja leka, kako bi se procenila stabilnost efekata leka. Obrada podataka urađena je pomoću STATA softvera, verzija 14, a nivo značajnosti je postavljen na p < 0,05. Rezultati. Pre intervencije, srednja vrednost sistolnog krvnog pritiska ispitanika iz grupe koja je primila ekstrakt lavande bila je 133,9 mmHg ± 9,3 mmHg, a iz placebo grupe 127,3 mmHg ± 6,3 mmHg. Nedelju dana nakon intervencije, srednje vrednosti krvnog pritiska ispitanika iz ovih grupa iznosile su 123,1 mmHg ± 12,6 mmHg i 125,8 mmHg ± 7,2 mmHg, a nakon dve nedelje 120,8 mmHg ± 10,7 mmHg i 127,9 mmHg ± 2 mmHg. Nedelju dana nakon prekida davanja leka, nivoi vrednosti krvnog pritiska ispitanika iz ovih grupa iznosili su 123,7 mmHg ± 10,7 mmHg i 129,2 mmHg ± 10,10 mmHg. Rezultati ponovljene ANOVA analize pokazali su da je ekstrakt lavande značajno uticao na vrednosti sistolnog i dijastolonog krvnog pritiska ispitanika iz interventne grupe (p < 0,05). Zaključak. Prema dobijenim rezultatima, ekstrakt lavande bio je efikasan u kontroli prehipertenzije kod populacije penzionera.
Abstract
Introduction/Aim: Hypertension is a common disorder of old age, which could be prevented by medicinal herbs. The present study aimed to evaluate the effect of lavender extract on prehypertension in the retired population. Methods: This triple-blind clinical trial was conducted on 60 retired men and women who were divided into two groups of lavender extract and placebo using the permuted block technique. Lavender extract (originating from flower part) and placebo were used twice a day (3 grams is equivalent to 3 cc each time) for two weeks. Blood pressure was measured before use, in the first and second week after use, and one week after the discontinuation of the medication to evaluate the stability of the drug effects. Data analysis was performed in STATA software version 14 at the significance level of p < 0.05. Results: Before the intervention, the mean systolic blood pressure in the lavender extract and placebo groups was 133.9 ± 9.3 mmHg and 127.3 ± 6.3 mmHg, respectively. After a one-week intervention, the mean blood pressure of the groups was 123.1 ± 12.6 mmHg and 125.8± 7.2 mmHg, respectively, while it was 120.8 ± 10.7 mmHg and 127.9 ± 2 mmHg after two weeks. One week after drug discontinuation, these levels were estimated at 123.7 ± 10.7 mmHg and 129.2 ± 10.10 mmHg, respectively. The results of repeated measures ANOVA indicated that lavender extract had significant effects on systolic and diastolic blood pressure in the intervention group (p < 0.05). Conclusion: According to the results, lavender extract was effective in prehypertension control in the retired subjects.
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