Pseudoexfoliation glaucoma: Always actual problem in ophthalmology

Vasović, Dolika; Marković, Vujica

doi:10.5937/mp69-13875

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Medicinski podmladak

2018, vol. 69, br. 2, str. 42-48

Pseudoeksfolijativni glaukom - uvek aktuelan problem u oftalmologiji

Vasović Dolika^a, Marković Vujica^b

^aUniverzitet u Beogradu, Medicinski fakultet
^bUniverzitet u Beogradu, Medicinski fakultet + Klinički centar Srbije, Klinika za očne bolesti, Beograd

e-adresa: dolika.vasovic@gmail.com

Ključne reči: PEX sindrom; kapsularni glaukom; učestalost

Sažetak

Uvod: Pseudoeksfolijativni (PEX) sindrom nije samo bolest oka, već je i opšti poremećaj sa abnormalnom produkcijom i deponovanjem depozita ekstracelularnog matriksa u intra i ekstraokularnim tkivima. Povišen intraokularni pritisak u očima sa pseudoeksfolijacijama dovodi do glaukomatoznih oštećenja u toku dužeg vremena i to u većem stepenu nego u očima bez pseudoeksfolijacija. Prognoza je lošija kod pseudoeksfolijativnog (kapsularnog) glaukoma nego kod primarnog glaukoma otvorenog ugla. Cilj: Cilj ovog rada bio je da ispita prisustvo i učestalost kapsularnog glaukoma u odnosu na druge tipove glaukoma u bolesničkom materijalu u toku mesec dana ambulantnog praćenja i u ukupnom broju glaukomno operisanih bolesnika u protekloj godini. Materijal i metode: Ispitivanjem je obuhvaćeno 105 pacijenata koji su oftalmološki pregledani u toku novembra 2016. godine, dok je uvidom u operativni protokol obuhvaćen uzorak od 346 pacijenata kod kojih je glaukom operisan u periodu od januara do oktobra iste godine na Klinici za očne bolesti Kliničkog centra Srbije. U pregledu su korišćene metode: biomikroskopije, aplanacione tonometrije, kompjuterizovane perimetrije, oftalmoskopije, gonioskopije i Hajdelbergove tomografije retine II. Rezultati: Iako je učestalost kapsularnog glaukoma u našem uzorku bila češća kod žena 14 (13,4 %) u odnosu na muškarce 11 (10,4 %), statistički značajna razlika u odnosu na pol nije zapažena (p = 0,352). Rezultati naše studije govore da se binokularni oblik kapsularnog glaukoma javlja 3,7 puta češće od monokularnog oblika kod žena, dok je kod muškaraca binokularni oblik 1,7 puta češći u odnosu na monokularni. Od ukupnog broja operisanih, zastupljenost kapsularnog glaukoma u odnosu na ostale vrste glaukoma iznosila je 94 (27,2 %) što ukazuje da je svaki četvrti operisani bolesnik imao dijagnozu kapsularnog glaukoma. Zaključak: Na osnovu rezultata ove studije može se zaključiti da kapsularni glaukom, kao najznačajnija okularna manifestacija PEX sindroma, pokazuje veliku učestalost i u našoj populaciji. Obavljanje pažljivog oftalmološkog pregleda kod osoba starijih od 50. godina se savetuje radi rane dijagnostike i otkrivanja prisustva pseudoeksfolijacija u oku.

Abstract

Introduction: Pseudoexfoliation (PEX) syndrome is not only an ocular disease but also a general disorder that involves the abnormal production and disposal of extracellular matrix material in intra- and extraocular tissues. Intraocular pressure (IOP) of the pseudoexfoliative eyes is higher than IOP of the nonpseudoexfoliative eyes which leads to more severe eye damage during longer period of time. Glaucoma in the pseudoexfoliation syndrome has been shown to have a more serious clinical course than in primary open-angle glaucoma. Aim: The aim of our study was to determine the presence and frequency of capsular glaucoma compared to other types of glaucoma among patients examined in one month period and in total number of glaucoma operated patients during last year. Materials and methods: Our study involved 105 patients examined and diagnosed in November 2016 and 346 glaucoma patients operated between January and October 2016 at Clinic for eye diseases, Clinical Centre of Serbia. Methods used in examination and monitoring of patients were: biomicroscopy, applanation tonometry, computerized perimetry, ophthalmoscopy, gonioscopy and Heidelberg Retinal Tomography II. Results: Although the frequency of capsular glaucoma in our sample was more common in women 14 (13.4 %) compared to men 11 (10.4 %), statistically significant difference related to sex was not observed (p = 0.352). Binocular expression was 3.7 times more often than monocular in women and 1.7 times in men. Among glaucoma operated patients, capsular glaucoma was found in 94 (27.2 %) cases, which leads to conclusion that every fourth patient operated last year had this type of glaucoma. Conclusion: Based on the results of our study it can be concluded that capsular glaucoma, as the most important ocular manifestation of PEX syndrome, shows high frequency in our population. Careful clinical examination should be performed in patients over the age of 50 due to the importance of early recognition and appropriate management of pseudoexfoliative material in the eye.

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O članku

jezik rada: srpski
vrsta rada: izvorni naučni članak
DOI: 10.5937/mp69-13875
objavljen u SCIndeksu: 13.07.2018.
metod recenzije: dvostruko anoniman

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