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2019, vol. 76, br. 6, str. 593-597
Karakteristike mukoze želuca i duodenuma kod bolesnika sa primarnim bilijarnim holangitisom
aKlinički centar Srbije, Klinika za gastroenterohepatologiju, Beograd + Univerzitet u Beogradu, Medicinski fakultet
bKlinički centar Srbije, Klinika za gastroenterohepatologiju, Beograd
cUniverzitet u Beogradu, Medicinski fakultet
dUniverzitet u Beogradu, Medicinski fakultet + Klinički centar Srbije, Služba za patohistologiju, Beograd
eUniverzitet u Beogradu, Medicinski fakultet + Institut za zaštitu zdravlja Srbije 'dr Milan Jovanović-Batut', Beograd

e-adresatamara.alempijevic@med.bg.ac.rs
Sažetak
Uvod/Cilj. Primarni bilijarni holangitis (PBC) je imunski posredovana hronična holestatska bolest jetre sa sporom progresijom. Cilj našeg istraživanja bio je da se utvrdi korelacija između PBC, atrofičnog gastritisa (AG) i glutensenzitivne enteropatije (GSE), da se identifikuju makroskopske i histopatološke promene mukoze želuca i duodenuma kod PBC i analizira učestalost ovih promena u poređenju sa kontrolnom grupom. Metode. U studiju je bilo uključeno 50 bolesnika sa PBC i 46 kontrolnih bolesnika sa dispeptičnim tegobama, bez bolesti jetre. Svi ispitanici su bili podvrgnuti ezofagogastroduodenoskopiji. Makroskopski i histopatološki nalaz i uzorak mukoze želuca i duodenuma su snimljeni i analizirani. Rezultati. Nije registrovana statističk iznačajna povezanost između PBC i AG, između PBC i Helicobacter pylori infekcije. Uočena je visokostatistički značajna razlika u učestalosti Helicobacter pylori infekcije i postojanja GSE kod bolesnika u kontrolnoj grupi u odnosu na one sa PBC. Zaključak. Bolesnici sa PBC imaju manji rizik za Helicobacter pylori infekciju i AG. Testiranje za GSE kod PBC bolesnika može biti korisno, s obzirom na veću učestalost GSE među ovim bolesnicima. GSE predstavlja faktor rizika od prisustva PBC i bolesnici sa GSE imaju skoro četiri puta veću predispoziciju za PBC.
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O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
DOI: 10.2298/VSP161123141P
objavljen u SCIndeksu: 11.07.2019.
metod recenzije: dvostruko anoniman
Creative Commons License 4.0

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