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Vojnosanitetski pregled
2019, vol. 76, br. 6, str. 593-597
Karakteristike mukoze želuca i duodenuma kod bolesnika sa primarnim bilijarnim holangitisom
Popović Dragana, Zgradić Sanjab, Dragašević Sanjab, Zec Simonc ORCID, Micev Marijand, Naumović Tamarae, Milosavljević Tomicaa ORCID, Milovanović Tamaraa
aKlinički centar Srbije, Klinika za gastroenterohepatologiju, Beograd + Univerzitet u Beogradu, Medicinski fakultet
bKlinički centar Srbije, Klinika za gastroenterohepatologiju, Beograd
cUniverzitet u Beogradu, Medicinski fakultet
dUniverzitet u Beogradu, Medicinski fakultet + Klinički centar Srbije, Služba za patohistologiju, Beograd
eUniverzitet u Beogradu, Medicinski fakultet + Institut za zaštitu zdravlja Srbije 'dr Milan Jovanović-Batut', Beograd

e-adresa: tamara.alempijevic@med.bg.ac.rs
Sažetak
Uvod/Cilj. Primarni bilijarni holangitis (PBC) je imunski posredovana hronična holestatska bolest jetre sa sporom progresijom. Cilj našeg istraživanja bio je da se utvrdi korelacija između PBC, atrofičnog gastritisa (AG) i glutensenzitivne enteropatije (GSE), da se identifikuju makroskopske i histopatološke promene mukoze želuca i duodenuma kod PBC i analizira učestalost ovih promena u poređenju sa kontrolnom grupom. Metode. U studiju je bilo uključeno 50 bolesnika sa PBC i 46 kontrolnih bolesnika sa dispeptičnim tegobama, bez bolesti jetre. Svi ispitanici su bili podvrgnuti ezofagogastroduodenoskopiji. Makroskopski i histopatološki nalaz i uzorak mukoze želuca i duodenuma su snimljeni i analizirani. Rezultati. Nije registrovana statističk iznačajna povezanost između PBC i AG, između PBC i Helicobacter pylori infekcije. Uočena je visokostatistički značajna razlika u učestalosti Helicobacter pylori infekcije i postojanja GSE kod bolesnika u kontrolnoj grupi u odnosu na one sa PBC. Zaključak. Bolesnici sa PBC imaju manji rizik za Helicobacter pylori infekciju i AG. Testiranje za GSE kod PBC bolesnika može biti korisno, s obzirom na veću učestalost GSE među ovim bolesnicima. GSE predstavlja faktor rizika od prisustva PBC i bolesnici sa GSE imaju skoro četiri puta veću predispoziciju za PBC.
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O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
DOI: 10.2298/VSP161123141P
objavljen u SCIndeksu: 11.07.2019.
metod recenzije: dvostruko anoniman
Creative Commons License 4.0

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