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2017, vol. 74, br. 1, str. 24-30
Prisustvo patohistoloških premalignih lezija i infekcija visokorizičnim genotipovima humanih papilomavirusa kod bolesnica sa sumnjivim citološkim i kolposkopskim nalazima - prospektivna studija
aCenter for Pathology and Forensic Medicine, Clinical Center of Montenegro, Faculty of Medicine, University of Montenegro, Podgorica, Montenegro
bCenter for Medical Microbiology, Institute of Public Health, Faculty of Medicine, University of Montenegro, Podgorica, Montenegro
cClinic of Gynecology and Obstetrics, Clinical Center of Montenegro, Podgorica, Montenegro

e-adresamiletagol@t-com.me
Sažetak
Uvod/Cilj. Kod premalignih lezija grlića materice infekcija visokorizičnim genotipovima humanih papilomavirusa (HPV) može spontano biti eliminisana, opstajati ili dovesti do transformacije epitela grlića nižeg u viši stepen. Zato je važno pravilno odabrati bolesnice koje su u visokom riziku od obolevanja od karcinoma. Cilj studije bio je da se ustanovi međuzavisnost sumnjivog Papanikolau testa i kolposkopskog nalaza sa infekcijom visokorizičnim genotipovima HPV i prisustvom premalignih lezija grlića materice. Metode. U ovoj prospektivnoj studiji korištena je citološka, kolposkopska, lančana reakcija polimeraze (PCR) u realnom vremenu visokorizičnih genotipova HPV, kao i patohistološka analiza bioptata grlića materice. Istraživanje je obuhvatilo 2 578 žena u Kliničkom Centru Crne Gore, koje su upućene na citološku analizu tokom 2012, 2013, i 2014. godine. Posmatrano je 80 žena kojima je indikovana biopsija grlića materice zbog sumnjivog Papanikolau testa i atipičnog kolposkopskog nalaza. Rezultati. U grupi od 80 (3,1%; n = 80/2 578) odabranih bolesnica sa sumnjivim Papanikolau testom i kolposkopijom, njih 2/3 ili 56 (70%) bilo je sa cervicitisom, a 1/3 ili 24 (30%) sa cervikalnom intraepitelnom neoplazijom. Najčešće zastupljeni pojedinačni tip kod bolesnica sa cervikalnom intraepitelnom neoplazijom bio je HPV16 kod 8 bolesnica, tj. 61,53% od broja inficiranih ili 33,33% od ukupnog broja premalignih lezija. Zaključak. Kod bolesnica koje imaju sumnjiv Papanikolau test i kolposkopski nalaz i infekciju visokorizičnim genotipovima HPV (posebno HPV16) česta je pojava cervikalnih intraepitelnih neoplazija. U tim situacijama, obavezna je patohistološka provera lezije, kao odlučujući dijagnostički postupak.
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O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
DOI: 10.2298/VSP150205143G
objavljen u SCIndeksu: 13.01.2017.
metod recenzije: dvostruko anoniman
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