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Vojnosanitetski pregled
2020, vol. 77, br. 3, str. 344-348
jezik rada: engleski
vrsta rada: prikaz slučaja
objavljeno: 15/04/2020
doi: 10.2298/VSP180224073Z
Creative Commons License 4.0
Metastaza malignog melanoma u ileum
aKlinički centar Vojvodine, Centar za patologiju i histologiju, Novi Sad + Univerzitet u Novom Sadu, Medicinski fakultet
bUniverzitet u Novom Sadu, Medicinski fakultet + Klinički centar Vojvodine, Klinika za vaskularnu i transplantacionu hirurgiju, Novi Sad
cUniverzitet u Novom Sadu, Medicinski fakultet + Klinički centar Vojvodine, Klinika za urologiju, Novi Sad

e-adresa: mirjana.zivojinov@mf.uns.ac.rs

Sažetak

Uvod. Maligni melanom je tumor koji se razvija od melanocita, ćelija koje proizvode pigment melanin, te se ovaj tip tumora može razviti u bilo kom delu tela koji sadrži ove ćelije. Melanom je ređi od drugih tumora kože, ali predstavlja izuzetno agresivan tip tumora kože koji vrlo rano daje metastaze i pripisuje mu se oko 75% slučajeva smrtnog ishoda zbog tumora kože. U početnoj fazi tumor ima horizontalan rast, te je vrlo značajno što ranije dijagnostikovanje promene. Vremenom tumor dobija i vertikalnu fazu rasta, te upravo od dubine invazije (Breslow) zavisi pojava metastaza. Tumor metastazira ne samo u regionalne limfne čvorove, već i u jetru, pluća, mozak i skoro svako mesto koje može biti naseljeno hematogenim putem. Prikaz bolesnika. U radu su prikazana dva bolesnika koja su hitno hirurški zbrinuta u Urgentnom centru Vojvodine zbog kliničkih simptoma i znakova ileusa. U oba slučaja urađene su resekcije ileuma sa terminalnom ileostomijom. Učinjena je patohistološka analiza i na osnovu imunohistohemije i morfološke slike u oba slučaja je postavljena dijagnoza metastaze malignog melanoma u ileum. Zaključak. Kod bolesnika kojima je dijagnostikovan maligni melanom kože sa simptomima bolova u stomaku i/ili anemijom, primena modernih imidžing tehnika je imperativ u cilju postavljanja rane dijagnoze gastrointestinalnih metastaza tog tumora. Brza detekcija i radikalna resekcija mogu doprineti dužini preživljavanja ovih bolesnika.

Ključne reči

Reference

Alwhouhayb, M., Mathur, P., Al, B.M. (2006) Metastatic melanoma presenting as a perforated small bowel. Turk J Gastroenterol, 17(3): 223-5
Atanackovic, M. (2003) Patologija. Beograd: Medicinski fakultet
Atmatzidis, K.S., Pavlidis, T.E., Papaziogas, B.T., Papaziogas, T.B. (2002) Primary malignant melanoma of the small intestine: Report of a case. Surgery Today, 32(9): 831-833
Baniukiewicz, A., Zaremba-Woroniecka, A., Wróblewski, E., Łaszewicz, W. (2000) Przerzutowy czerniak złośliwy żołądka jako przyczyna krwawienia z przewodu pokarmowego. Opis przypadku. Gastroenterologia Polska, 7: 61-3. (Polish)
Begg, C.B., Hummer, A., Mujumdar, U., Armstrong, B.K., Kricker, A., Marrett, L.D., Millikan, R.C., Gruber, S.B., Anton-Culver, H., Klotz, J.B., Zanetti, R., Gallagher, R.P., Dwyer, T., Rebbeck, T.R. (2004) Familial aggregation of melanoma risks in a large population-based sample of melanoma cases. Cancer Causes and Control, 15(9): 957-965
Bender, G.N., Maglinte, D.D.T., Mclarney, J.H., Rex, D., Kelvin, F.M. (2001) Malignant melanoma: Patterns of metastasis to the small bowel, reliability of imaging studies, and clinical relevance. American Journal of Gastroenterology, 96(8): 2392-2400
Betti, R., Agape, E., Vergani, R., Moneghini, L., Cerri, A. (2016) An observational study regarding the rate of growth in vertical and radial growth phase superficial spreading melanomas. Oncology Letters, 12(3): 2099-2102
Blecker, D., Abraham, S., Furth, E.E., Kochman, M.L. (1999) Melanoma in the gastrointestinal tract. American Journal of Gastroenterology, 94(12): 3427-3433
Breslow, A. (1970) Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. Annals of Surgery, 172(5): 902-908
Brummel, N., Awad, Z., Frazier, S., Liu, J., Rangnekar, N. (2005) Perforation of metastatic melanoma to the small bowel with simultaneous gastrointestinal stromal tumor. World Journal of Gastroenterology, 11(17): 2687-2689
Cholakov, O., Tsekov, K.H., Beliaev, O., Stefanov, P., Cherveniakov, A. (2003) Disseminated malignant melanoma, complicated with upper-digestive hemorrhage. Khirurgiia, Sofiia, 59(3): 52-3. (Bulgarian)
Essner, R., Lee, J.H., Wanek, L.A., Itakura, H., Morton, D.L. (2004) Contemporary surgical treatment of advanced-stage melanoma. Archives of Surgery, 139(9): 961-6; discussion 966-7
Fallah, M., Pukkala, E., Sundquist, K., Tretli, S., Olsen, J.H., Tryggvadottir, L., et al. (2014) Familial melanoma by histology and age: Joint data from five Nordic countries. Eur J Cancer, 50(6): 1176-83
Faries, M.B., Thompson, J.F., Cochran, A.J., Andtbacka, R.H., Mozzillo, N., Zager, J.S., et al. (2017) Completion dissection or observation for sentinel-node metastasis in melanoma. N Engl J Med, 376(23): 2211-2222
Gassenmaier, M., Eigentler, T.K., Keim, U., Goebeler, M., Fiedler, E., Schuler, G., Leiter, U., Weide, B., Grischke, E., Martus, P., Garbe, C. (2017) Serial or parallel metastasis of cutaneous melanoma?: A study of the German Central Malignant Melanoma Registry. Journal of Investigative Dermatology, 137(12): 2570-2577
Godlewski, J., Kuciel-Lisieska, G., Tenderenda, M., Troska, P., Widawski, T. (2009) Przerzuty czerniaka do narządów przewodu pokarmowego. Nowotwory, 59: 96-8. (Polish)
Gutman, H., Ben-Ami, E., Shapira-Frommer, R., Schachter, J. (2012) Multidisciplinary management of very advanced stage III and IV melanoma: Proof-of-principle. Oncology Letters, 4(2): 307-310
Jerant, A.F., Johnson, J.T., Sheridan, C.D., Caffrey, T.J. (2000) Early detection and treatment of skin cancer. Am Fam Physician, Jul 15; 62(2), 357-68, 375-376, 381-382
Kadakia, C.S., Parker, A., Canales, L. (1992) Metastatic tumors to the upper gastrointestinal tract: Endoscopic experience. Am J Gastroenterol, 87(10): 1418-23
Kanavy, H.E., Gerstenblith, M.R. (2011) Ultraviolet radiation and melanoma. Seminars in Cutaneous Medicine and Surgery, 30(4): 222-228
Klausner, J.M., Skornick, Y., Lelcuk, S., Baratz, M., Merhav, A. (1982) Acute complications of metastatic melanoma to the gastrointestinal tract. British Journal of Surgery, 69(4): 195-196
Kruse, J., Heath, R. (1990) Melanoma metastatic to the gastrointestinal tract. Am Fam Physician, 41(1): 165-8
Kumar, V., Abbas, A.K., Fausto, N., Mitchell, R.N. (2007) Robbins basic pathology. New York: Elsevier - Saunders
Kycler, W., Łaski, P., Porzegowski, M., Teresiak, M. (2006) Chirurgiczne leczenie przerzutów do odległych narządów wprzebiegu czerniaka - opis przypadku. Wspolczesna Onkologia, 4: 175-8. (Polish)
Leiter, U., Stadler, R., Mauch, C., Hohenberger, W., Brockmeyer, N., Berking, C., Sunderkötter, C., Kaatz, M., Schulte, K., Lehmann, P., Vogt, T., Ulrich, J., Herbst, R., Gehring, W., Simon, J. (2016) Complete lymph node dissection versus no dissection in patients with sentinel lymph node biopsy positive melanoma (DeCOG-SLT): A multicentre, randomised, phase 3 trial. Lancet Oncology, 17(6): 757-767
Morton, D.L., Thompson, J.F., Cochran, A.J., Mozzillo, N., Elashoff, R., Essner, R., Nieweg, O.E., Roses, D.F., Hoekstra, H.J., Karakousis, C.P., Reintgen, D.S., Coventry, B.J., Glass, E.C. (2006) Sentinel-node biopsy or nodal observation in melanoma. New England Journal of Medicine, 355(13): 1307-1317
Morton, D.L., Thompson, J.F., Cochran, A.J., Mozzillo, N., Nieweg, O.E., Roses, D.F., Hoekstra, H.J., Karakousis, C.P., Puleo, C.A., Coventry, B.J., Kashani-Sabet, M., Smithers, B. M., Paul, E. (2014) Final trial report of sentinel-node biopsy versus nodal observation in melanoma. New England Journal of Medicine, 370(7): 599-609
Mucci, T., Long, W., Witkiewicz, A., Mastrangelo, M.J., Rosato, E.L., Berger, A.C. (2007) Metastatic melanoma causing jejunal intussusception. Journal of Gastrointestinal Surgery, 11(12): 1755-1757
Ollila, D.W., Essner, R., Wanek, L.A., Morton, D.L. (1996) Surgical resection for melanoma metastatic to the gastrointestinal tract. Archives of Surgery, 131(9): 975-9; 979-80
Pirisi, M., Leutner, M., Grazioli, S., Bartoli, E.G. (2004) A woman with anemia and a small-bowel obstruction. Canadian Medical Association Journal (CMAJ), 170(5): 788-788
Tsilimparis, N., Menenakos, C., Rogalla, P., Braumann, C., Hartmann, J. (2009) Malignant melanoma metastasis as a cause of small-bowel perforation. Onkologie, 32(6): 356-358
Wat, H., Salopek, T.G. (2017) Revisiting vertical growth phase and regression for thin melanoma. Journal of the American Academy of Dermatology, 76(1): e27-e27
Wysocki, W.M., Komorowski, A.L., Darasz, Z. (2004) Gastrointestinal metastases from malignant melanoma: Report of a case. Surgery Today, 34(6): 542-546