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Vojnosanitetski pregled
2015, vol. 72, br. 3, str. 295-298
jezik rada: engleski
vrsta rada: prikaz slučaja
doi:10.2298/vsp1503295i


Hiperkalcemični tip sitnoćelisjkog karcinoma jajnika
aUniverzitet u Kragujevcu, Medicinski fakultet
bDepartment of Pathology, Clinical Center Kragujevac, Kragujevac
cFaculty of Medical Sciences, Kragujevac + Department of Pathology, Clinical Center Kragujevac, Kragujevac
dFaculty of Medical Sciences, Kragujevac + Department of Gynaecology and Obstretics, Clinical Center Kragujevac, Kragujevac
eDepartment of Oncology, Clinical Center Kragujevac, Kragujevac

e-adresa: drmilosavljevic@sbb.rs

Sažetak

Uvod. Ekstrapulmonalni sitnoćelijski karcinom je retka, prognostički loša kategorija tumora. Primarno, može da se lokalizuje u skoro svim organima, pa i u jajniku, gde zbog svojih kliničkih specifičnosti, često predstavlja pravi dijagnostički i terapijski izazov. Sitnoćelijski karcinom jajnika (small cell ovarian carcinoma SCOC) biološki je vrlo agresivan maligni tumor nepoznate histogeneze. U radu je prikazana bolesnica u post-menopauzi sa sitnoćelijskim karcinomom jajnika i hiperkalcemijom, agresivnog toka i fatalnog ishoda, u International Federation of Gynecology and Obstetrics FIGO Ia stadijumu. Prikaz bolesnika. Žena stara 60 godina, javila se zbog tegoba u donjem abdomenu praćenih bolom jakog intenziteta. Ultrazvučnim pregledom i kompjuterizovanom tomografijom abdomena ustanovljeno je prisustvo velike adneksalne mase cističnog izgleda sa najvećim promerom od 13 cm, sa urednom strukturom drugih ginekoloških organa i bez prisustva metastatskih depozita. Svi rezultati laboratorijske analize bili su u granicama normalnih vrednosti izuzev povišenih nivoa kalcijuma u serumu. Izvršena je eksplorativna laparotomija sa kompletnom histerektomijom, bileteralnom salpingooforektomijom, disekcijom limfnih čvorova i omentektomijom. Na osnovu patohistološke analize operatvnog materijala postavljena je dijagnoza SCOC stadijuma Ia. U postoperativnom periodu nije bilo komplikacija i bolesnica je otpuštena deset dana posle operacije u dobrom stanju i normalizovanom kalcemijom. Lečenje je nastavljeno istovremenom radioi hemioterapijom. Međutim, bez obzira na preduzete mere lečenja, bolest je progradirala i bolesnica je umrla zbog diseminovane metastatske bolesti 26 meseci posle postavljanja dijagnoze. Zaključak. Sitnoćelijski karcinom lokalizovan u jajniku najčešće je kategorija tumora sa lošom prognozom u zavisnosti od faze bolesti.

Ključne reči

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