2018, vol. 19, br. 1, str. 35-40
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Stil života kao faktor rizika za nastanak karcinoma bubrega - iskustva iz Rusije
Lifestyle risk factors in the development of kidney cancer: A Russian experience
aKrasnoyarsk State Medical University, Krasnoyarsk, Russia bI.M. Sechenov First Moscow State Medical University, Moscow, Russia
e-adresa: bolevich2011@yandex.ru
Sažetak
Cilj ovog istraživanja bio je evaluacija najznačajnijih faktora rizika koji potiču od stila života na razvoj karcinoma bubrežnih ćelija (KBĆ) i procena šanse za razvoj bolesti u regionu, u zavisnosti od prisutnosti ispitivanih faktora rizika. Faktori rizika za razvoj karcinoma bubrežnih ćelija koji su povezani sa stilom života (upotreba nikotina, gojaznost i hipertenzija) su posmatrani kod 500 pacijenata obolelih od karcinoma bubrežnih ćelija starosti 30-64 godina u Onkološkoj klinici Krasnojark (eksperimentalna grupa) i 858 ispitanika u kontrolnoj grupi u Krai. Rezultati studije su pokazali da upotreba nikotina 2,9 puta, dok hipertenzija 3,3 puta povećava rizik za razvoj karcinoma bubrežnih ćelija kod muškaraca; sa druge strane kod žena gojaznost i hipertenzija povećavaju ovaj rizik za 2,6 i 3,2 puta. Sva tri faktora rizika su bila prisutna kod 13,6% muškaraca i 8,4% žena sa karcinomom bubrežnih ćelija. Ovi podaci mogu biti od koristi za prevenciju bolesti, razvoj programa za skrining i ranu dijagnozu karcinoma bubrežnih ćelija.
Abstract
The objective of our study was the evaluation of major lifestyle risk factors for the development of renal cell carcinoma (RCC) and the assessment of chances of developing this disease among inhabitants in the region, in the presence of and with combinations of the studied risk factors. Risk factors for developing RCC that are associated with lifestyle (smoking, obesity and hypertension) were observed in 500 patients with RCC aged 30-64 years who were investigated at the Krasnoyarsk Oncology Dispensary (study group) and 858 participants in the Krai (control group). The results of our study showed that smoking increases the risk of developing RCC 2.9 times and arterial hypertension 3.3 times in men; in women, obesity and hypertension increased these risks 2.6 and 3.2 times, respectively. All three risk factors were combined in 13.6% of men and in 8.4% of women with RCC. Our data may be useful for the prevention, development of screening programmes and early diagnosis of RCC.
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