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2020, vol. 39, br. 4, str. 415-421
Ispitivanje povezanosti između povećanja ekstra-srčanog troponina i rizika od budućeg mortaliteta
aUniversity of Verona, University Hospital of Verona, Section of Clinical Biochemistry, Verona, Italy
bUniversity of Valencia, Faculty of Medicine, Department of Physiology, Valencia, Spain + INCLIVA Biomedical Research Institute, Valencia, Spain

e-adresagiuseppe.lippi@univr.it
Ključne reči: mortalitet; infarkt miokarda; srčano oštećenje; troponin
Sažetak
Mada su merenja srčanog troponina I (cTnI) i T (cTnT) ključna za dijagnostikovanje srčanog oštećenja, kako ishemijskog tako i ne-ishemijskog poslednji dokazi ukazuju da se kod mnogih pacijenata javljaju ekstra-srčani uzroci povećanja CTn i dovode do značajno povećanog rizika od budućeg mortaliteta. Podaci iz trenutno dostupne literature ukazuju da povećanja cTn mogu da se podjednako pojave kod pacijenata sa srčanim i ekstra-srčanim oboljenjima. Kod poslednjih ispitivanih pacijenata vodeća ekstra-srčana oboljenja koja mogu biti odgovorna za povećanje cTnI ili cTnT su infektivna oboljenja/sepsa, plućni poremećaji, bubrežna oboljenja, maligna oboljenja, kao i gastrointestinalna, neurološka i mišićnoskeletna oboljenja. Prilično jasno trenutni literaturni podaci ukazuju da je rizik od umiranja od ekstra-srčanih oboljenja visok (npr. između dva do tri puta) u pacijenata sa ekstra-srčanim cTn povećanjima nego kod onih sa kardiološkom patologijom, i da najčešći uzrok smrti može biti infekcija/sepsa, praćena sa malignim, respiratornim poremećajima, infarktom miokarda, gastrointestinalnim i neurološkim oboljenjima, poremećajem rada srca, šlogom, srčanim aritmijama, bubrežnim poremećajem, psihijatrijskim, metaboličkim, urogenitalnim i mišićnoskeletnim poremećajima. Ovi podaci mogu da vode ka zaključku da postoji značajan rizik da druge patologije mogu dovesti do srčanog oštećenja i povećanja cTn te mogu biti i uzrok smrti ovih pacijenata. Ovaj značajni dokaz vodiće ka definisanju odgovarajuće i efektivne strategije za praćenje pacijenata sa povećanjem ekstra-srčanog cTn, kako bi rizik od buduće smrti bio preveniran ili umanjen.
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O članku

jezik rada: engleski
vrsta rada: prilog
PMC ID: PMC7710372
DOI: 10.5937/jomb0-25262
objavljen u SCIndeksu: 02.10.2020.
Creative Commons License 4.0

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