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Vojnosanitetski pregled
2020, vol. 77, br. 8, str. 773-783
Supresorske ćelije mijeloidnog porekla u sekundarnoj sepsi - postoji li povezanost sa smrtnim ishodom?
Udovičić Ivoa, Šurbatović Majaa, Rondović Gorana, Stanojević Ivanb, Zeba Snježanaa, Đorđević Dragana, Popadić Anac, Milosavljević Snežanad, Stanković Nikolae, Abazović Džihanf, Vojvodić Danilob ORCID
aVojnomedicinska akademija, Klinika za anesteziologiju i intenzivnu terapiju, Beograd + Univerzitet odbrane, Medicinski fakultet Vojnomedicinske akademije, Beograd
bUniverzitet odbrane, Medicinski fakultet Vojnomedicinske akademije, Beograd + Vojnomedicinska akademija, Institut za medicinska istraživanja, Beograd
cVojnomedicinska akademija, Klinika za anesteziologiju i intenzivnu terapiju, Beograd
dUniverzitet u Prištini sa privremenim sedištem u Kosovskoj Mitrovici, Medicinski fakultet, Kliničko-bolnički centar
eUniverzitet u Beogradu, Medicinski fakultet, Institut za zdravstvenu zaštitu majke i deteta Republike Srbije 'Dr Vukan Čupić' + Univerzitet u Beogradu, Medicinski fakultet
fEmergency Medical Centar of Montenegro, Podgorica, Montenegro

e-adresa: maja.surbatovic@gmail.com
Sažetak
Uvod/Cilj. Uloga supresorskih ćelija mijeloidnog porekla (MDSCs) u imunskom odgovoru bolesnika sa sepsom tek treba da bude razjašnjena kod ljudi. Cilj istraživanja je bio da se utvrdi da li kod kritično obolelih sa sekundarnom sepsom i/ili septičkim šokom postoji udruženost učestalosti i/ili apsolutnih brojeva MDSCs sa ishodom bolesti. Metode. U prospektivnu studiju je bilo uključeno ukupno 40 kritično obolelih pacijenata sa sekundarnom sepsom. Detektovane su i kvantifikovane obe glavne podvrste MDSCs: granulocitna (G)-MDSCs i monocitna (M)-MDSCs, po prijemu na bolničko lečenje (prvi dan) i petog dana posle prijema. Primarni ishod je bio bolnički mortalitet. Rezultati. Veća učestalost i apsolutni brojevi subpopulacija koje odgovaraju MDSCs bili su udruženi sa lošim ishodom. Što se relativne kinetike tiče, i kod preživelih i kod umrlih, trajanje sepse od prvog do petog dana bilo je praćeno povećanjem vrednosti MDSCs u obe ispitivane subpopulacije. Multivarijantna logistička regresiona analiza je pokazala da su, za razliku od prvog dana, petog dana the Sequential Organ Failure Assessment (SOFA) skor (OR 2.350; p < 0,05) i frekvenca G-MDSCs (OR 3.575; p < 0,05) bili nezavisni prediktori letalnog ishoda. Zaključak. Ovi nalazi ukazuju na štetnu ulogu MDSCs u sekundarnoj sepsi.
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O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
DOI: 10.2298/VSP180706133U
objavljen u SCIndeksu: 13.09.2020.
metod recenzije: dvostruko anoniman
Creative Commons License 4.0

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