Metrika članka

  • citati u SCindeksu: 0
  • citati u CrossRef-u:0
  • citati u Google Scholaru:[=>]
  • posete u poslednjih 30 dana:1
  • preuzimanja u poslednjih 30 dana:1
članak: 1 od 8  
Back povratak na rezultate
Srpski arhiv za celokupno lekarstvo
2019, vol. 147, br. 9-10, str. 571-577
jezik rada: engleski
vrsta rada: originalan članak
doi:10.2298/SARH190204031J
Hirurško lečenje tumora dojki u dečjem uzrastu
aInstitute for Child and Youth Health Care of Vojvodina, Clinic of Pediatric Surgery, Novi Sad + University of Novi Sad, Faculty of Medicine
bUniversity of Novi Sad, Faculty of Medicine + Oncology Institute of Vojvodina, Sremska Kamenica

e-adresa: radoica.jokic@mf.uns.ac.rs

Sažetak

Uvod/Cilj Fibroadenomi, usled svoje izrazite pokretljivosti zvani i "miševi dojke", najčešći su tumori dojke u dečjem uzrastu. Uzevši u obzir činjenice da tumori dojke mogu svojim rastom da remete razvoj njenog normalnog žlezdanog tkiva i da ne postoji idealan način za dijagnostikovanje ovih tumora, operativno lečenje sa kompletnom resekcijom predstavlja "zlatni standard" u terapiji. Cilj ove studije je da prikaže kliničko iskustvo Klinike za dečju hirurgiju u Novom Sadu u lečenju ove patologije. Metode Istraživanje je koncipirano kao deskriptivnoretrospektivna studija. Analizirane su bolesnice lečene od tumora dojki na Institutu za zdravstvenu zaštitu dece i omladine Vojvodine u Novom Sadu u periodu 2011-2018. godine. Rezultati Studiju čini 29 bolesnica, prosečne starosti 15,8 ± 1,8 godina. Većina tumora je pozicionirana u gornjem spoljašnjem (27,6%) i donjem unutrašnjem (24,1%) kvadrantu dojki. Tumori su bili prosečnog prečnika 39,7 mm. Uočeno je kako su kod bolesnica sa pozitivnom porodičnom anamnezom u pravcu tumora dojke tumori bili manjih dimenzija u poređenju sa onim kod bolesnica sa negativnom porodičnom anamnezom (27,5 mm u poređenju sa 43,2 mm). U studiji nije bilo maligniteta i kod svih bolesnica načinjena je totalna ekstirpacija tumora. Hospitalizacija je u proseku iznosila jedan i po dan. Zaključak U zavisnosti od veličine i lokalizacije tumora, odgovarajuća radikalna operacija i dalje predstavlja "zlatni standard" u lečenju tumora dojke kod dece. Saradnja se ekspertima iz oblasti onkološke hirurgije omogućava da ova patologija postane rutina u radu dečjih hirurga.

Ključne reči

fibroadenomi dojke; filodes tumori; operativno lečenje; deca

Reference

Ahmed, S., Tate, J., Thrift-Perry, M., Wait, S. (2018) Barriers and opportunities in genetic testing for BRCA gene mutations in Europe: A strategic policy response to support women and families at risk for breast cancer. J Glob Oncol, 4(2)
Bhatia, S., Robinson, L., Oberlin, O., Greenberg, M., Bunin, G., Fossatibellani, F. (1996) Breast cancer and other second neoplasms after childhood Hodgkin's disease. N Engl J Med, 334(12), 745-751
Cerrato, F., Labow, B. (2013) Diagnosis and management of fibroadenomas in the adolescent breast. Semin Plast Surg, 27(1), 23-25
Cucinotta, M., Cistaro, A. (2014) Phylloid tumor of the breast. u: Cistaro A. [ur.] Atlas of PET/CT in Pediatric Patients, Milano: Springer
Gao, Y., Saksena, M., Brachtel, E., ter Meulen, D. (2015) How to approach breast lesions in children and adolescents. Eur J Radiol, 84(7), 1350-1364
Gatta, G., Iaselli, F., Parlato, V., di Grezia, G., Grassi, R., Rotondo, A. (2011) Differential diagnosis between fi broadenoma, giant fi broadenoma and phyllodes tumour: Sonographic features and core needle biopsy. Radiol Med, 116(6), 905-918
Greenberg, R., Skornick, Y., Kaplan, O. (1998) Management of breast fibroadenomas. J Gen Intern Med, 13(9), 640-645
Gunasekaran, G., Naik, D., Sharma, S., Bhandari, V., Mandal, A.K., Rajput, D. (2014) Recurrent phyllodes tumor of the breast transforming to a fibrosarcoma. Int Surg J, 1(3), 173-176
Jang, J.H., Choi, M.Y., Lee, S.K., Kim, S., Kim, J., Lee, J., et al. (2012) Clinicopathologic risk factors for the local recurrence of phyllodes tumors of the breast. Ann Surg Oncol, 19(8), 2612-2617
Kaneda, H., Mack, J., Kasales, C., Schetter, S. (2013) Pediatric and adolescent breast masses: A review of pathophysiology, imaging, diagnosis, and treatment. AJR Am J Roentgenol, 200(2), 204-212
Kennedy, R., Boughey, J. (2013) Management of pediatric and adolescent breast masses. Semin Plast Surg, 27(1), 19-22
Kuijper, A., Mommers, E., Wall, E., Diest, P. (2001) Histopathology of fibroadenoma of the breast. Am J Clin Pathol, 115(5), 736-742
Lee, M., Soltanian, M.T. (2015) Breast fibroadenomas in adolescents: Current perspectives. Adolesc Health Med Ther, 6, 159-163
Lim, W.K., Ong, C.K., Tan, J., Thike, A.A., Ng, Y.C.C., Rajasegaran, V., et al. (2014) Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma. Nat Genet, 46(8), 877-880
Mavaddat, N., Pharoah, P., Michaidiolu, K., Tyrer, J., Brook, M., Bolla, M. (2015) Prediction of breast cancer risk based on profiling with common genetic variants. J Natl Cancer Inst, 107(5)
Mercato-Matos, J., Matthew-Onabanjo, A., Shaw, L. (2017) RUNX1 and breast cancer. Oncotarget, 8(23), 36934-36935
Muller, K.E., Tafe, L.J., Abreu, F.B., Peterson, J.D., Wells, W.A., Barth, R.J., et al. (2015) Benign phyllodes tumor of the breast recurring as a malignant phyllodes tumor and spindle cell metaplastic carcinoma. Hum Pathol, 46(2), 327-333
Ng, W., Mrad, A., Beown, M. (2011) Juvenile fibroadenoma of the breast: Treatment and literature review. Can J Plast Surg, 19(3), 105-107
Pinto, J., Aguiar, A.T., Duarte, H., Vilaverde, F., Rodrigues, A., Krug, J.L. (2014) Simple and complex fibroadenomas: Are there any distinguishing sonographic features. J Ultrasound Med, 33(3), 415-419
Sanders, L.M., Sharma, P., El-Madany, M., King, A.B., Goodman, K.S., Sanders, A.E. (2018) Clinical breast concerns in low-risk pediatric patients: Practice review with proposed recommendations. Pediatr Radiol, 48(2), 186-195
Sharma, B.B., Bhardwaj, N., Dewan, S., Aziz, M.R. (2017) Adolescent fibroadenoma (Breast 'Mouse'): Role of radiology in assisting diagnosis: A case report. EJMCR, 1(1), 5-9
Sherwani, A.M. (2014) Comparison of management and treatment options for recurrent breast fibroadenomas in adolescent females. BS: Boston University, http://hdl.handle.net/2144/17045
Siegel, M., Chung, E. (2017) Breast masses in children and adolescents. Appl Radiol, 46(9), 12-17
Silwal-Pandit, L., Moen, V.H.K., Chin, S.F., Rueda, O., McKinney, S., Osako, T., et al. (2014) TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic relevance. Clin Cancer Res, 20(13), 1-12
Sosin, M., Pulcrano, M., Feldman, E., Patel, K., Nahabedian, M., Weisller, J. (2015) Giant juvenile fibroadenoma: A systematic review with diagnostic and treatment recommendations. Gland Surg, 4(4), 312-321
Stehr, K.G., Lebeau, A., Stehr, M., Grantzow, R. (2004) Fibroadenoma of the breast in an 11-year-old girl. Eur J Pediatr Surg, 14(1), 56-59
Tan, P.H., Thike, A.A., Tan, W.J., Thu, M.M., Busmanis, I., Li, H. (2012) Predicting clinical behaviour of breast phyllodes tumours: A nomogram based on histological criteria and surgical margins. J Clin Pathol, 65(1), 69-76
Thuruthiyath, N., Das, P.C., Avabratha, S., Mascarenhas, V., Marla, N. (2012) Giant fibroadenoma of breast in an adolescent girl. Oman Med J, 27(4), 314-315
Zhang, Y., Kleer, C.G. (2016) Phyllodes tumor of the breast histopathologic features, differential diagnosis, and molecular/genetic updates. Arch Pathol Lab Med, 140(7), 665-671
Zhang, Y., Walsh, M., Wu, G., Edmonson, M., Gruber, T., Easton, J. (2015) Germline mutations in predisposition genes in pediatric cancer. N Engl J Med, 373, 2336-2346