Metrika članka

  • citati u SCindeksu: 0
  • citati u CrossRef-u:0
  • citati u Google Scholaru:[=>]
  • posete u poslednjih 30 dana:10
  • preuzimanja u poslednjih 30 dana:2
članak: 2 od 34  
Back povratak na rezultate
Vojnosanitetski pregled
2020, vol. 77, br. 3, str. 247-255
jezik rada: engleski
vrsta rada: izvorni naučni članak
objavljeno: 15/04/2020
doi: 10.2298/VSP171106066N
Creative Commons License 4.0
Salivarni i inflamatorni medijatori plazme i sekretorni status prevremeno porođenih žena sa periodontitisom - studija preseka
aKlinički centar Srbije, Klinika za ginekologiju i akušerstvo, Beograd
bUniverzitet u Beogradu, Stomatološki fakultet, Klinika za parodontologiju i oralnu medicinu
cUniverzitet u Beogradu, Stomatološki fakultet
dKlinički centar Srbije, Centar za medicinsku biohemiju, Beograd
eUniverzitet u Beogradu, Farmaceutski fakultet, Institut za medicinsku biohemiju
fUniverzitet u Novom Sadu, Medicinski fakultet, Klinika za stomatologiju
gKlinički centar Srbije, Klinika za ginekologiju i akušerstvo, Beograd + Univerzitet u Beogradu, Medicinski fakultet

e-adresa: ljubinka.nikolic@kcs.ac.rs

Projekat

Genetička kontrola i molekularni mehanizmi u malignim, inflamatornim i razvojnim patologijama orofacijalne regije (MPNTR - 175075)
Interakcija etiopatogenetskih mehanizama parodontopatije i paeriimplantitisa sa sistemskim bolestima današnjice (MPNTR - 41008)

Sažetak

Uvod/Cilj. Prevremeni porođaj se definiše kao porođaj pre navršene 37 nedelje gestacije. Podaci iz literature govore u prilog tome da periodontalni procesi mogu uticati na fetoplacentalnu jedinicu i indukovati preterminski porođaj. Sekretorni status može uticati na stepen periodontalne bolesti. Proinflamatorni citokini imaju uticaj na periodontitis kao i na porođaj. Kombinovani uticaj ovih faktora rizika za prevremeni porođaj nije dovoljno istražen. Cilj ove studije je bio da istraži povezanost između periodontalne bolesti, sekretornog statusa, nivoa interleukina 1-b (IL1-b) i prostaglandina E2 (PGE2) kod žena koje su imale prevremeni porođaj. Metode. Studijom je bilo obuhvaćeno 56 žena, koje su imale prevremen porođaj i 56 žena u kontrolnoj grupi koje su se porodile u terminu, starosti između 17 i 41 godine. Periodontalni pregled, uzorkovanje krvi i salive je izvršeno u prvih 48 sati po porođaju. Sekretorni status je određen metodom inhibicije hemaglutinacije. Koncentracije IL1-b i PGE2 su merene visoko senzitivnim Enzyme-linked Immunosorbent Assay (ELISA) testom. Rezultati. U grupi prevremenih porođaja bilo je 66,1% žena sa periodontitisom, a u kontrolnoj grupi 12,5% (p < 0.01). Prevremeno porođene žena, nesekretori sa periodontitisom imale su u plazmi značajno više vrednosti IL 1-b i PGE 2 u odnosu na ostale grupe (p < 0,01). U grupi prevremeno porođenih žena postojala je značajna korelacija između salivarnih i plazmatskih koncentracija PGE2 i IL1-b (R = 0.416, p = 0.017 i R = -0,592, p < 0,001, redom). Ove korelacije nisu postojale kod žena koje su imale terminski porođaj. Zaključak. Naši rezultati podržavaju hipotezu da su sekretorni status i periodontitis, bar delimično, odgovorni za patogenezu preterminskog porođaja. Verovatnoća negativnog uticaja nesekretornog statusa se ne sme ignorisati. Ovi zaključci ukazuju na potrebu za dodatnim istraživanjima porođaja.

Ključne reči

Reference

Abati, S., Villa, A., Cetin, I. (2015) Oral environment, inflammation and preterm birth. J Pediatr Neonat Individual Med, 4(2): e040239
Amirisetty, R., Patel, R.P., Das, S., Saraf, J., Jyothy, A., Munshi, A. (2015) Interleukin 1b(+3954, -511 and -31) polymorphism in chronic periodontitis patients from North India. Acta Odontologica Scandinavica, 73(5): 343-347
Armitage, G.C. (1999) Development of a classification system for periodontal diseases and conditions. Annals of Periodontology, 4(1): 1-6
Armitage, G.C. (2001) Periodontal disease and pregnancy: Discussion, conclusions, and recommendations. Annals of Periodontology, 6(1): 189-192
Beck, S., Wojdyla, D., Say, L., Bertran, A.P., Meraldi, M., Requejo, J.H., Rubens, C., Menon, R., van Look, P. (2010) The worldwide incidence of preterm birth: A systematic review of maternal mortality and morbidity. Bulletin of the World Health Organization, 88(1): 31-38
Blencowe, H., Cousens, S., Oestergaard, M.Z., Chou, D., Moller, A., Narwal, R., Adler, A., Vera, G.C., Rohde, S., Say, L., Lawn, J.E. (2012) National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: A systematic analysis and implications. Lancet, 379(9832): 2162-2172
Boggess, K.A., Moss, K., Madianos, P., Murtha, A.P., Beck, J., Offenbacher, S. (2005) Fetal immune response to oral pathogens and risk of preterm birth. American Journal of Obstetrics and Gynecology, 193(3 Pt 2): 1121-1126
Chaemsaithong, P., Romero, R., Korzeniewski, S.J., Dong, Z., Yeo, L., Hassan, S.S., Kim, Y.M., Yoon, B.H., Chaiworapongsa, T. (2015) A point of care test for the determination of amniotic fluid interleukin-6 and the chemokine CXCL-10/IP-10. Journal of Maternal-Fetal & Neonatal Medicine, 28(13): 1510-1519
Chukkapalli, S.S., Rivera-Kweh, M.F., Velsko, I.M., Chen, H., Zheng, D., Bhattacharyya, I., Gangula, P.R., Lucas, A.R., Kesavalu, L. (2015) Chronic oral infection with major periodontal bacteria Tannerella forsythia modulates systemic atherosclerosis risk factors and inflammatory markers. Pathogens and Disease, 73(3), pii: ftv009
Corbella, S., Taschieri, S., del Fabbro, M., Francetti, L., Weinstein, R., Ferrazzi, E. (2016) Adverse pregnancy outcomes and periodontitis: A systematic review and meta-analysis exploring potential association. Quintessence Int, 47(3): 193-204
Dörtbudak, O., Eberhardt, R., Ulm, M., Persson, G. R. (2005) Periodontitis: A marker of risk in pregnancy for preterm birth. Journal of Clinical Periodontology, 32(1): 45-52
Ferrero, D.M., Larson, J., Jacobsson, B., di Renzo, G.C., Norman, J.E., Martin, J.N. J., D'Alton, M., Castelazo, E., Howson, C.P., Sengpiel, V., Bottai, M., Mayo, J.A., Shaw, G.M., Verdenik, I., Tul, N. (2016) Cross-country individual participant analysis of 4.1 million singleton births in 5 countries with very high human development index confirms known associations but provides no biologic explanation for 2/3 of all preterm births. PLoS One, 11(9): e0162506-e0162506
Gloria-Bottini, F., Magrini, A., Cozzoli, E., Neri, A., Pietroiusti, A., Amante, A., Bottini, E. (2011) ABH secretor genetic polymorphism: Evidence of intrauterine selection. European Journal of Obstetrics & Gynecology and Reproductive Biology, 154(1): 20-23
Gringhuis, S.I., Kaptein, T.M., Wevers, B.A., Theelen, B., van der Vlist, M., Boekhout, T., Geijtenbeek, T.B.H. (2012) Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1b via a noncanonical caspase-8 inflammasome. Nature Immunology, 13(3): 246-254
Gümüş, P., Öztürk, V. Ö., Bozkurt, E., Emingil, G. (2016) Evaluation of the gingival inflammation in pregnancy and postpartum via 25-hydroxy-vitamin D3, prostaglandin E 2 and TNF-a levels in saliva. Archives of Oral Biology, 63: 1-6
Gunput, S.T.G., Ligtenberg, A.J.M., Terlouw, B., Brouwer, M., Veerman, E.C.I., Wouters, D. (2015) Complement activation by salivary agglutinin is secretor status dependent. Biological Chemistry, 396(1): 35-43
Jarjoura, K., Devine, P.C., Perez-Delboy, A., Herrera-Abreu, M., D'Alton, M., Papapanou, P.N. (2005) Markers of periodontal infection and preterm birth. American Journal of Obstetrics and Gynecology, 192(2): 513-519
Kamei, H., Ishihara, Y., Fuma, D., Niwa, T., Kamiya, Y., Yokoi, T., Suzuki, M., Izawa, A., Mizutani, H., Hayashi, J., Sakaki, Y., Noguchi, T., Kojima, T. (2014) Interleukin-1 receptor gene variants are associated with aggressive periodontitis in the Japanese. Archives of Oral Biology, 59(7): 756-763
Karjalainen, M.K., Huusko, J.M., Ulvila, J., Sotkasiira, J., Luukkonen, A., Teramo, K., Plunkett, J., Anttila, V., Palotie, A., Haataja, R., Muglia, L.J., Hallman, M. (2012) A potential novel spontaneous preterm birth gene, AR, identified by linkage and association analysis of X chromosomal markers. PLoS One, 7(12): e51378-e51378
Kędzierska-Markowicz, A., Krekora, M., Biesiada, L., Głowacka, E., Krasomski, G. (2015) The evaluation of correlation between IL-1b, Il-8, IFN-g cytokines concentration in cervico-vaginal fluid and the risk of preterm delivery. Polish Gynaecology / Ginekol Pol, 86(11): 821-827 (Polish)
Kinney, J.S., Morelli, T., Braun, T., Ramseier, C.A., Herr, A.E., Sugai, J.V., Shelburne, C.E., Rayburn, L.A., Singh, A.K., Giannobile, W.V. (2011) Saliva/pathogen biomarker signatures and periodontal disease progression. Journal of Dental Research, 90(6): 752-758
Lewis, Z.T., Totten, S.M., Smilowitz, J.T., Popovic, M., Parker, E., Lemay, D.G., van Tassell, M.L., Miller, M.J., Jin, Y., German, J. B., Lebrilla, C.B., Mills, D.A. (2015) Maternal fucosyltransferase 2 status affects the gut bifidobacterial communities of breastfed infants. Microbiome, 3(1): 13-13
Lieff, S., Boggess, K.A., Murtha, A.P., Jared, H., Madianos, P.N., Moss, K., Beck, J., Offenbacher, S. (2004) The oral conditions and pregnancy study: Periodontal status of a cohort of pregnant women. Journal of Periodontology, 75(1): 116-126
Lopez-Castejon, G., Brough, D. (2011) Understanding the mechanism of IL-1b secretion. Cytokine & Growth Factor Reviews, 22(4): 189-195
Madianos, P.N., Bobetsis, Y.A., Offenbacher, S. (2013) Adverse pregnancy outcomes (APOs) and periodontal disease: Pathogenic mechanisms. Journal of Clinical Periodontology, 40(4 Suppl): S170-S180
Medawar, P.B. (1953) Some immunological and endocrinological problems raised by the evolution of viviparity in vertebrates. Symp Soc Exp Biol, 7, str. 320-38
Michalowicz, B.S., Novak, M. J., Hodges, J.S., Diangelis, A., Buchanan, W., Papapanou, P.N., Mitchell, D.A., Ferguson, J.E., Lupo, V., Bofill, J., Matseoane, S., Steffen, M., Ebersole, J.L. (2009) Serum inflammatory mediators in pregnancy: Changes after periodontal treatment and association with pregnancy outcomes. Journal of Periodontology, 80(11): 1731-1741
Miller, W.D. (1891) The human mouth as a focus of infection. Dental Cosmos, 33(9): 689-713
Nikolić, Lj., Janković, Lj., Čakić, S., Movsesijan, A. (1996) Secretory status and periodontal disease. Bilten za transfuziologiju, 42(1): 23-6. (Serbian)
Nurjadi, D., Lependu, J., Kremsner, P.G., Zanger, P. (2012) Staphylococcus aureus throat carriage is associated with ABO-/secretor status. Journal of Infection, 65(4): 310-317
Oliveira, C.F., Soares, D.O.A.M., Miranda, C.L.O. (2013) Interrelation between periodontal disease and preterm birth. u: Erez O [ur.] Preterm birth, Rijeka: InTech, p. 3-39
Rathnayake, N., Åkerman, S., Klinge, B., Lundegren, N., Jansson, H., Tryselius, Y., Sorsa, T., Gustafsson, A. (2013) Salivary biomarkers of oral health: A cross-sectional study. Journal of Clinical Periodontology, 40(2): 140-147
Robinson, P., Schmerman, M. (2015) Influence of pregnancy on the oral cavity. Glob libr women's med, [about 5 p], https://www.glowm.com [cited 2017 Jun 19]
Rocha, D.M., Zenóbio, E.G., van Dyke, T., Silva, K.S., Costa, F.O., Soares, R.V. (2012) Differential expression of salivary glycoproteins in aggressive and chronic periodontitis. J Appl Oral Sci, 20(2): 180-185
Romero, R., Miranda, J., Chaemsaithong, P., Chaiworapongsa, T., Kusanovic, J.P., Dong, Z., Ahmed, A.I., Shaman, M., Lannaman, K., Yoon, B.H., Hassan, S.S., Kim, C.J., Korzeniewski, S.J., Yeo, L., Kim, Y.M. (2015) Sterile and microbial-associated intra-amniotic inflammation in preterm prelabor rupture of membranes. Journal of Maternal-Fetal & Neonatal Medicine, 28(12): 1394-1409
Romero, R., Xu, Y., Plazyo, O., Chaemsaithong, P., Chaiworapongsa, T., Unkel, R., Than, N.G., Chiang, P.J., Dong, Z., Xu, Z., Tarca, A.L., Abrahams, V.M., Hassan, S.S., Yeo, L., Gomez-Lopez, N. (2018) A role for the inflammasome in spontaneous labor at term. American Journal of Reproductive Immunology, 79(6): e12440-e12440
Roth-Isigkeit, A., Hasselbach, L., Ocklitz, E., Brückner, S., Ros, A., Gehring, H.A., Schmucker, P., Rink, L., Seyfarth, M. (2001) Inter-individual differences in cytokine release in patients undergoing cardiac surgery with cardiopulmonary bypass. Clinical and Experimental Immunology, 125(1): 80-88
Saini, R., Saini, S., Saini, S.R. (2010) Periodontitis: A risk for delivery of premature labor and low-birth-weight infants. Journal of Natural Science, Biology and Medicine, 1(1): 40-42
Shiozaki, A., Yoneda, S., Nakabayashi, M., Takeda, Y., Takeda, S., Sugimura, M., Yoshida, K., Tajima, A., Manabe, M., Akagi, K., Nakagawa, S., Tada, K., Imafuku, N., Ogawa, M., Mizunoe, T. (2014) Multiple pregnancy, short cervix, part-time worker, steroid use, low educational level and male fetus are risk factors for preterm birth in Japan: A multicenter, prospective study. Journal of Obstetrics and Gynaecology Research, 40(1): 53-61
Soucy-Giguère, L., Tétu, A., Gauthier, S., Morand, M., Chandad, F., Giguère, Y., Bujold, E. (2016) Periodontal disease and adverse pregnancy outcomes: A prospective study in a low-risk population. Journal of Obstetrics and Gynaecology Canada, 38(4): 346-350
Stadelmann, P.F.M., Eick, S., Salvi, G.E., Surbek, D., Mohr, S., Bürgin, W., Ramseier, C.A., Sculean, A. (2015) Increased periodontal inflammation in women with preterm premature rupture of membranes. Clinical Oral Investigations, 19(6): 1537-1546
Tabasum, S.T., Nayak, R.P. (2011) Salivary blood group antigens and microbial flora. International Journal of Dental Hygiene, 9(2): 117-121
Vamvakopoulos, J.E., Taylor, C.J., Green, C., Mcneil, K., Wallwork, J., Goodman, R., Metcalfe, S.M. (2002) Interleukin 1 and chronic rejection: Possible genetic links in human heart allografts. American Journal of Transplantation, 2(1): 76-83
Walia, M., Saini, N. (2015) Relationship between periodontal diseases and preterm birth: Recent epidemiological and biological data. Int J Appl Basic Med Res, 5(1): 2-6
Walker, R.H., ed. (1993) Blood grouping and typing. American Association of Blood Banks, Technical manual, 621-38
Zhumakanova, K., Abeuova, B., Kuzgibekova, A., Kenzhebayeva, K., Eremicheva, G. (2016) Some clinical and immunological aspects of preterm birth. Georgian Med News, (253): 17-25 (Russian)