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Scientific Technical Review
2019, vol. 69, br. 3, str. 15-29
jezik rada: engleski
vrsta rada: neklasifikovan
objavljeno: 13/05/2020
doi: 10.5937/str1903015A
Creative Commons License 4.0
Estri organofosfornih kiselina, toksičnost, primena i uklanjanje iz životne sredine
aUniverzitet u Beogradu, Fakultet za fizičku hemiju + Vojnotehnički institut - VTI, Beograd
bUniverzitet u Beogradu, Institut za nuklearne nauke Vinča, Beograd-Vinča
cUniverzitet odbrane, Vojna akademija, Beograd

e-adresa: rkarkalic@yahoo.com

Projekat

Istraživanja interakcija enzima sa toksičnim i farmakološki aktivnim molekulima (MPNTR - 172023)
Vodonična energija - razvoj novih materijala: elektrolitičko dobijanje vodonika, vodonične gorivne ćelije, izotopski efekti (MPNTR - 172045)
Primena nanomaterijala u unapređenju sredstava respiratorne i perkutane zaštite u uslovima ekološkog disbalansa izazvanog radioaktivnom, hemijskom i biološkom kontaminacijom (MPNTR - 34034)
391-00-16 / 2017-16 / 3

Sažetak

Estri organofosfornih kiselina su danas u upotrebi širom sveta. Primenjuju se kao pesticidi, lekovi i bojni otrovi. Njihova akutna toksičnost pripisuje se inhibiciji acetilholinesteraze, koja je ključni enzim u prenošenju nervnih impulsa kod sisara. Toksični efekat estara organofosfornih kiselina manifestuje se akumulacijom acetilholina, što može dovesti do niza neželjenih efekata, uključujući paralizu ili čak smrt. Terapija trovanja organofosfatima zasniva se na primeni specifičnih protivotrova, kao i različitih nespecifičnih i simptomatskih tretmana. U ovom preglednom članku daćemo prikaz najnovijih dostignuća na polju zaštite od negativnog dejstva organofosfata, kao i pregled novih metoda za njihovo uklanjanje iz životne sredine i dekontaminaciju osoba koje su došle u neposredan kontakt sa estrima organofosfornih kiselina.

Ključne reči

estri organofosfornih kiselina; pesticidi; nervni agensi; toksičnost; životna sredina; remedijacija

Reference

Naknadno pridodat članak: provera, normiranje i linkovanje referenci u toku.
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