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Journal of Medical Biochemistry
2014, vol. 33, br. 3, str. 245-251
jezik rada: engleski
vrsta rada: izvorni naučni članak
objavljeno: 16/01/2020
doi: 10.2478/jomb-2014-0010
Povećanje nivoa hitotriozidaze kod bolesnika sa reumatoidnim artritisom - može li to biti novi indikator?
aIstanbul Medeniyet University, Goztepe Teaching and Research Hospital, Medical Biochemistry Department, Istanbul, Turkey
bIstanbul University, Cerrahpasa Medicine Faculty, Biochemistry Department, Istanbul, Turkey
cIstanbul Medeniyet University, Goztepe Teaching and Research Hospital, Internal Medicine Department, Istanbul, Turkey

e-adresa: drisbilen@yahoo.com

Sažetak

Uvod: Hitotriozidaza i YKL-40 su dobro poznati kao proteini koji sadrže domen Gliko_18, koji je zajednička karakteristika hitinaze sisara i proteina sličnih hitinazi. Ranije se pokazalo da su povećani nivoi YKL-40 povezani sa delovanjem reumatoidnog artritisa. Svrha ove studije je određivanje nivoa YKL40 i hitotriozidaza kod bolesnika sa reumatoidnim artritisom i upoređivanje sa uobičajenim indikatorima kao što su C-reaktivni protein i brzina sedimentacije eritrocita. Metode: Nivoi hitotriozidaza, YKL-40, C-reaktivni protein i brzina sedimentacije eritrocita u uzorcima seruma 27 bolesnika sa reumatoidnim artritisom i 27 zdravih osoba izmereni su redom fluorometrijskom, ELISA, nefelometrijskom i Western-Green metodom. Rezultati: U serumu grupe bolesnika sa reumatoidnim artritisom je zabeležena veca aktivnost hitotriozidaza i nivo YKL-40 u poređenju sa zdravim ispitanicima. Između hitotriozidaza i YKL-40 postoji statistički značajna pozitivna korelacija. U analizi ROC, za hitotriozidaze, C-reaktivni protein, brzine sedimentacije eritrocita i YKL-40, područja ispod krive su redom zauzela 0,96, 0,84, 0,76 i 0,65. Vrednost područja ispod krive testa za hitotriozidaze je bila znatno veća od vrednosti područja ispod krive brzine sedimentacije eritrocita (p=0,005) i YKL-40 (p=0,0001), ali identična sa područjem za C-reaktivni protein (p=0,055). Zaključak: Aktivnost hitotriozidaze u serumu bolesnika sa reumatoidnim artritisom je u vidljivom porastu. Između svih procenjenih parametara utvrđeno je da je hitotriozidaza najosetljivija i najspecifičnija. Postoji potreba za opsežnim studijama na polju hitinaze, koje obuhvataju veće populacije i koje će istražiti odnos između hitotriozidaza i reumatoidnog artritisa.

Ključne reči

hitotriozidaza; C-reaktivni proteini; inflamacija; reumatoidni artritis; YKL-40

Reference

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