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Medicinski podmladak
2016, vol. 67, br. 2, str. 39-42
jezik rada: engleski
vrsta rada: pregledni članak
doi:10.5937/medpodm1602039P

Creative Commons License 4.0
Efekat treninga na vrednosti adiponektina u plazmi vrhunskih sportista
aUniverzitet u Beogradu, Medicinski fakultet
bFaculty of Medicine, University of Belgrade + Institute of Medical Physiology 'Richard Burian'

Sažetak

Masno tkivo je endokrini organ, koji oslobađa biološki aktivne adipokine. Jedan od adipokina je adiponektin, protein strukturno sličan komplementu 1q, koji ima značajnu ulogu u metaboličkim poremećajima zbog antiinflamatornog dejstva, anti-aterogenih svojstava i dejstva na insulin. Receptori AdipoR1 i AdipoR2 posreduju metaboličko dejstvo adiponektina aktiviranjem adenozin-monofosfat aktivirane proteinkinaze (AMPK) i peroksizom proliferator aktiviranog receptora alfa (PPAR- α), što dovodi do povećanog katabolizma i oksidacije masnih kiselina, preuzimanja glukoze u miocitima, smanjenja glukoneogeneze i povećanja osetljivosti na insulin. Na nivoe adiponektina utiče više činilaca: pol (žene imaju više vrednosti adiponektina u plazmi), bolesti povezane sa gojaznošću (metabolički sindrom, tip 2 dijabetesa melitusa i ateroskleroza su povezane sa nižim vrednostima adiponektina) i način života (uključujući vežbanje). Do danas se ipak malo zna o uticaju rekretivnog vežbanja na nivoe adiponektina, a posebno o uticaju treninga na nivo adiponektina u populaciji sportista. U ovom radu smo prikazali pregled literature o efektima treninga na nivoe adiponektina u plazmi vrhunskih sportista. Koncentracija adiponektina pokazuje odloženo povećanje (30 min) nakon kratkotrajnog intenzivnog treninga u sportista oba pola. Prema podacima iz literature, koncentracije adiponektina se ne menjaju kao odgovor na dugotrajno vežbanje. Kod sportista posle treninga nema značajne razlike u nivou ukupnog adiponektina vs. oligomera visoke molekularne težine (HMW). Adiponektin može da služi za praćenje opterećenja tokom treninga i postavljanje individualnih normi za intenzitet treninga. Potrebna su dalja istraživanja radi pojašnjenja mogućih mehanizama kojima adiponektin utiče na energetsku homeostazu kod vrhunskih sportista tokom treninga.

Ključne reči

Reference

Aldhahi, W., Hamdy, O. (2003) Adipokines, inflammation, and the endothelium in diabetes. Current diabetes reports, 3(4): 293-8
Berg, A.H., Scherer, P.E. (2005) Adipose tissue, inflammation, and cardiovascular disease. Circulation research, 96(9): 939-49
Ebinuma, H., Miyazaki, O., Yago, H., Hara, K., Yamauchi, T., Kadowaki, T. (2006) A novel ELISA system for selective measurement of human adiponectin multimers by using proteases. Clinica Chimica Acta, 372(1-2): 47-53
Evans, R.M., Barish, G.D., Wang, Y. (2004) PPARs and the complex journey to obesity. Nature medicine, 10(4): 355-61
Fasshauer, M., Klein, J., Neumann, S., Eszlinger, M., Paschke, R. (2001) Adiponectin gene expression is inhibited by beta-adrenergic stimulation via protein kinase A in 3T3-L1 adipocytes. FEBS Lett, 507(2): 142-6
Fisher, F.F.M., Trujillo, M.E., Hanif, W., Barnett, A.H., McTernan, P.G., Scherer, P.E., Kumar, S. (2005) Serum high molecular weight complex of adiponectin correlates better with glucose tolerance than total serum adiponectin in Indo-Asian males. Diabetologia, 48(6): 1084-7
Ivy, J.L. (1997) Role of exercise training in the prevention and treatment of insulin resistance and non-insulin-dependent diabetes mellitus. Sports medicine (Auckland, N.Z.), 24(5): 321-36
Jürimäe, J., Purge, P., Jürimäe, T. (2007) Effect of prolonged training period on plasma adiponectin in elite male rowers. Hormone and metabolic research, 39(7): 519-23
Jürimäe, J., Purge, P., Jürimäe, T. (2006) Adiponectin and stress hormone responses to maximal sculling after volume-extended training season in elite rowers. Metabolism: clinical and experimental, 55(1): 13-9
Jürimäe, J., Purge, P., Jürimäe, T. (2005) Adiponectin is altered after maximal exercise in highly trained male rowers. European journal of applied physiology, 93(4): 502-5
Kershaw, E.E., Flier, J.S. (2004) Adipose tissue as an endocrine organ. Journal of clinical endocrinology and metabolism, 89(6): 2548-56
Kraemer, R.R., Aboudehen, K.S., Carruth, A.K., Durand, R.J., Acevedo, E.O., Hebert, E.P., Johnson, L.G., Castracane, V. D. (2003) Adiponectin Responses to Continuous and Progressively Intense Intermittent Exercise. Medicine & Science in Sports & Exercise, 35(8): 1320-1325
Lara-Castro, C., Luo, N., Wallace, P., Klein, R.L., Garvey, W. (2006) Adiponectin multimeric complexes and the metabolic syndrome trait cluster. Diabetes, 55(1): 249-59
Lee, S.H., Hong, H.R., Han, T.K., Kang, H.S. (2015) Aerobic training increases the expression of adiponectin receptor genes in the peripheral blood mononuclear cells of young men. Biology of sport, 32(3): 181-6
Lombardi, G., Lanteri, P., Graziani, R., Colombini, A., Banfi, G., Corsetti, R. (2012) Bone and Energy Metabolism Parameters in Professional Cyclists during the Giro d’Italia 3-Weeks Stage Race. PLoS ONE, 7(7): e42077
Nigroa, E., Sangiorgiob, D., Scudieroa, O., Monacoa, M.L., Politoa, R. (2016) Gene molecular analysis and Adiponectin expression in professional Water Polo players. Cytokine, 81: 883
Ouchi, N., Kihara, S., Arita, Y., Maeda, K., Kuriyama, H., Okamoto, Y., i dr. (1999) Novel modulator for endothelial adhesion molecules: Adipocyte-derived plasma protein adiponectin. Circulation, 100, str. 2473-76
Pajvani, U.B., Du, X., Combs, T.P., Berg, A.H., Rajala, M.W., Schulthess, T., Engel, J., Brownlee, M., Scherer, P.E. (2003) Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity. Journal of biological chemistry, 278(11): 9073-85
Parm, A., Jürimäe, J., Saar, M., Pärna, K., Tillmann, V., Maasalu, K., Neissaar, I., Jürimäe, T. (2012) Bone mineralization in rhythmic gymnasts before puberty: no longitudinal associations with adipocytokine and ghrelin levels. Hormone research in paediatrics, 77(6): 369-75
Plinta, R., Olszanecka-Glinianowicz, M., Drosdzol-Cop, A., Chudek, J., Skrzypulec-Plinta, V. (2012) The effect of three-month pre-season preparatory period and short-term exercise on plasma leptin, adiponectin, visfatin, and ghrelin levels in young female handball and basketball players. Journal of endocrinological investigation, 35(6): 595-601
Röhling, M., Herder, C., Stemper, T., Müssig, K. (2016) Influence of Acute and Chronic Exercise on Glucose Uptake. Journal of Diabetes Research, 2016: 1-33
Roupas, N.D., Maïmounb, L., Mamalia, I., Costeb, O., Tsoukaa, A. (2012) The influence of intensive physical training on salivary adipokine levels in Elite Rhythmic Gymnasts. Horm Metab Res., 44 (13); 980-6
Roupas, N., Mamali, I., Maragkos, S., Leonidou, L., Armeni, A., Markantes, G., Tsekouras, A., Sakellaropoulos, G., Markou, K., Georgopoulos, N. (2013) The effect of prolonged aerobic exercise on serum adipokine levels during an ultra-marathon endurance race. Hormones, 12(2): 275-282
Roupas, N.D., Maïmoun, L., Mamali, I., Coste, O., Tsouka, A., Mahadea, K.K., Mura, T., Philibert, P., Gaspari, L., Mariano-Goulart, D., Leglise, M., Sultan, C., Georgopoulos, N.A. (2014) Salivary adiponectin levels are associated with training intensity but not with bone mass or reproductive function in elite Rhythmic Gymnasts. Peptides, 51: 80-85
Ryan, A.S. (2000) Insulin resistance with aging: effects of diet and exercise. Sports medicine (Auckland, N.Z.), 30(5): 327-46
Salmenniemi, U., Ruotsalainen, E., Pihlajamäki, J., Vauhkonen, I., Kainulainen, S., Punnonen, K., Vanninen, E., Laakso, M. (2004) Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin, cytokines, and adhesion molecules in subjects with metabolic syndrome. Circulation, 110(25): 3842-8
Scherer, P.E., Williams, S., Fogliano, M., Baldini, G., Lodish, H.F. (1995) A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem, 270(45): 26746-9
Shing, C.M., Webb, J.J., Driller, M.W., Williams, A.D., Fell, J.W. (2013) Circulating adiponectin concentration and body composition are altered in response to high-intensity interval training. Journal of strength and conditioning research, 27(8): 2213-8
Shinsuke, N., Mami, F., Kokoro, T., Sachiko, F., Akihiko, U., Yasuharu, K., i dr. (2016) ACTN3 gene R577X polymorphism associated with high-density lipoptotein, cholesterol and adiponectin in rugny players: Endocrine practice. Press AACE, Rapid Electronic Article
Simpson, K.A., Singh, M.A. (2008) Effects of exercise on adiponectin: a systematic review. Obesity (Silver Spring, Md.), 16(2): 241-56
Varamenti, E.I., Kyparos, A., Veskoukis, A.S., Bakou, M., Kalaboka, S., Jamurtas, A.Z., Koutedakis, Y., Kouretas, D. (2013) Oxidative stress, inflammation and angiogenesis markers in elite female water polo athletes throughout a season. Food and Chemical Toxicology, 61: 3-8
Voss, S.C., Nikolovski, Z., Bourdon, P.C., Alsayrafi, M., Schumacher, Y.O. (2016) The effect of cumulative endurance exercise on leptin and adiponectin and their role as markers to monitor training load. Biology of sport, 33(1): 23-8
Xu, A., Chan, K.W., Hoo, R.L.C., Wang, Y., Tan, K.C.B., Zhang, J., Chen, B., Lam, M.C., Tse, C., Cooper, G.J.S., Lam, K.S.L. (2005) Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes. Journal of biological chemistry, 280(18): 18073-80
Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., i dr. (2002) Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med, 8(11), str. 1288-95