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Journal of Medical Biochemistry
2017, vol. 36, br. 1, str. 1-7
jezik rada: engleski
vrsta rada: pregledni članak
objavljeno: 23/01/2020
PMC ID: PMC5471653
doi: 10.1515/jomb-2016-0029
Savremeni biohemijski monitoring i upravljanje rizikom imunosupresivnog tretmana nakon transplantacije
aUniverzitet u Nišu, Medicinski fakultet
bUniverzitet u Nišu, Medicinski fakultet + Klinički centar Niš, Klinika za nefrologiju

e-adresa: aleksandra1610@yahoo.com

Projekat

Preventivni, terapijski i etički pristup prekliničkim i kliničkim istraživanjima gena i modulatora redoks ćelijske signalizacije u imunskom, inflamatornom i proliferativnom odgovoru ćelije (MPNTR - 41018)

Sažetak

Imunosupresivni protokol ima značajnu ulogu u inhibiciji imunog odgovora prilikom transplantacije organa, kao i u farmakoterapiji autoimunih bolesti. Efektivna imunosupresija mora posedovati odgovarajući bezbednosni profil i obezbediti pozitivne terapijske odgovore i bolji kvalitet života pacijenta. Do sada nije definisan model koji predviđa rizik za pacijente sa transplantiranim organom, iako su prepoznati najznačajniji faktori rizika. Terapijski monitoring imunosupresivnih lekova (TDM) osnovno je, ali ne i dovoljno sredstvo za predviđanje ukupne izloženosti organizma lekovima sa varijabilnom kinetikom. Istovremeni terapijski, biohemijski i klinički monitoring mogu uspešno prilagoditi terapiju individualnom pacijentu sa optimalnim medicinskim odgovorima. Savremeno upravljanje terapijom trebalo bi da uključi nove biomarkere, čija senzitivnost i specifičnost omogućavaju identifikaciju ranog ćelijskog oštećenja. Cilj ovog rada je da istakne važnost pronalaženja novih biomarkera koji bi imali mogućnost rane detekcije neželjenih efekata lekova i ćelijskog oštećenja kod pacijenata sa transplantiranim organom. Pored toga, razmatran je značaj rutinskog biohemijskog monitoringa u svrhu poboljšanja bezbednosti imunosupresivnog protokola.

Ključne reči

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