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Vojnosanitetski pregled
2017, vol. 74, br. 11, str. 1060-1065
jezik rada: engleski
vrsta rada: izvorni naučni članak
doi:10.2298/VSP151224293D

Creative Commons License 4.0
Promena biomarkera oksidativnog stresa i funkcije endotela posle šestonedeljnog aerobnog fizičkog treninga kod bolesnika sa stabilnom ishemijskom bolesti srca
aUniversity of Niš, Faculty of Medicine, Institute of Pathophysiology
bClinical Center Niš, Institute of Radiology
cClinical Center Niš, Clinic of Cardiology
dUniversity of Niš, Faculty of Medicine, Institute of Biomedical Research

e-adresa: boris_dj@medfak.ni.ac.rs

Projekat

Monitoring elektromagnetnih zracenja mobilnih telekomunikacionih sistema u životnoj sredini, analiza molekularnih mehanizama i biomarkera oštecenja kod hronicne izloženosti sa razvojem modela za procenu rizika i metoda za zaštitu (MPNTR - 43012)
Preventivni, terapijski i eticki pristup preklinickim i klinickim istraživanjima gena i modulatora redoks celijske signalizacije u imunskom, inflamatornom i proliferativnom odgovoru celije (MPNTR - 41018)

Sažetak

Uvod/Cilj. Redovna fizička aktivnost u sklopu kardiovaskularne rehabiltacije popravlja endotelnu funkciju, redukuje kardiovaskularni mortalitet i anginozne tegobe bolesnika sa kardiovaskularnim oboljenjem. U radu su analizirane promene parametara oksidativnog stresa i endotelne funkcije nakon sprovedenog redovnog aerobnog fizičkog treninga tokom šest nedelja kod bolesnika sa stabilnom formom koronarne bolesti (KB) uključenih u program kardiovaskularne rehabilitacije. Metode. Analizirano je 35 uzastopnih bolesnika sa stabilnom formom KB, uključenih u program kardiovaskularne rehabilitacije sa redovnom aerobnom fizičkom aktivnošću tokom šest nedelja, zajedno sa 37 kontrolnih bolesnika sa KB, uparenih prema polu i starosti, sa sedentarnim načinom života. Anamnestički podaci o komorbiditetima, faktorima rizika od kardiovaskularnih bolesti, primenjenoj terapiji, klinički podaci o antropometrijskim i kardiovaskularnim parametrima kao i laboratorijske analize: adhezioni molekuli, derivati oksidativne modifikacije proteina (RCD), derivati lipidne peroksidacije malondialdehid (MDA) i azot monoksid (NO) određivani su na početku i nakon šest nedelja aerobnog treninga. Trening se sastojao od 45 minuta kontinuirane fizičke aktivnosti (do 80% maksimalne srčane frekvencije), tri puta nedeljno. Rezultati. Karakteristike grupa na početku studije bile su slične u pogledu polne i starosne strukture, kao i prisustva faktora rizika od kardiovaskularnih bolesti. Redovna aerobna fizička aktivnost dovodila je do značajne redukcije indeksa telesne mase, krvnog pritiska, srčane frekvencije, koncentracije triglicerida, RCD (1,27 ± 0,48 µmol/g proteins naspram 1,04 ± 0,22 µmol/g proteins), sVCAM-1 [100.4 (IQR) (78,4-118,3) ng/mL naspram 80,0 IQR (68,5-97,2 µmol/g proteins)] i povećanja NO (64,72 ± 16,06 µmol/g proteins prema 74,38 ± 18,57) i HDL holesterola (p < 0,05), što nije registrovano u sedentarnoj kontroli: RCD (1,16 ± 0,25 naspram 1,12 ± 0,14), sVCAM-1 [92,2 IQR (73,6-106,8) naspram 91,3 IQR(73,0-105,3)] i NO (68,5 ± 17,9 naspram 65,7 ± 19,6). Serumske vrednosti intracelularnog adhezionog molekula sICAM-1 su startno bile niže u grupi sa primenjenim treningom bez značajne promene tokom praćenja [80,74 IQR (54,92-97,3) vs 80,36 IQR (68,1-95,3)] u odnosu na kontrolnu grupu [86,35 IQR (57,32-95,8)] vs 84,65 IQR (55,67-93,8). U grupi sa fizičkim treningom vrednosti sVCAM-1 i RCD su bile značajno niže a NO više na kraju studije u poređenju sa kontrolnom grupom. Zaključak. Redovan fizički trening indukuje smanjenje intenziteta oksidativnog stresa i ćelijskih adhezionih molekula uz porast bioraspoloživog NO i povoljne promene HDL holesterola i triglicerida.

Ključne reči

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