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Psihijatrija danas
2012, vol. 44, iss. 1, pp. 21-33
article language: Serbian
document type: Research Paper
published on: 22/03/2013
The influence of comorbid depression on the quality of life in persons with epilepsy
aUniversity of Belgrade, Faculty of Medicine, Institute of Mental Health
bUniversity of Belgrade, Faculty of Medicine + University of Belgrade, Faculty of Medicine, Institute of Mental Health
cUniversity of Belgrade, Faculty of Medicine, Institute of Mental Health + Ministarstvo zdravlja Republike Srbije



Purpose: to assess symptoms of depression and to define its influence on quality of life (QOL) in patients with epilepsy. Method: Adult patients (age range 18-65 years) with normal intelligence and without any progressive neurological disease or psychotic disorder were included in the study. They completed Beck's Depression Inventory (BDI), Symptom Check List - 90 (SCL-90), Quality of life in epilepsy Inventory - 31 (QOLIE-31) - Serbian version, and Hamilton depressive scale, which was completed by investigator. Multiple regression analysis was performed to assess the predictive effects of depression scales scores on QOLIE- 31 total score. Results: 11.8% of patients had clinical diagnosis of depression and were previously treated with antidepressants. According to Beck's depression inventory, symptoms of depression were present in 33% of patients. Multiple regression analysis showed significant correlation between three instruments for depression: BDI, HAMD and SCL-90 depression score and overall score of QOLIE-31. 64% of overall score was determined by those scores (F=51.88; p<0.001; R2= 0.63). Tests of regression coefficients significance showed that only BDI score was significant predictor of QOLIE-31 (beta =-0.55; t=-5.17; p<0.001). All subscales of QOLIE- 31 were negatively and moderately correlated with instruments of depression (r=-0.334 to - 0.744). Conclusion: depression is frequently coexisting psychiatric condition in patients with epilepsy which has significant influence on QOL.



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