Article metrics

  • citations in SCindeks: 0
  • citations in CrossRef:0
  • citations in Google Scholar:[=>]
  • visits in previous 30 days:12
  • full-text downloads in 30 days:7
article: 2 from 152  
Back back to result list
Psihijatrija danas
2012, vol. 44, iss. 1, pp. 21-33
article language: Serbian
document type: Research Paper
published on: 22/03/2013
The influence of comorbid depression on the quality of life in persons with epilepsy
aUniversity of Belgrade, Faculty of Medicine, Institute of Mental Health
bUniversity of Belgrade, Faculty of Medicine + University of Belgrade, Faculty of Medicine, Institute of Mental Health
cUniversity of Belgrade, Faculty of Medicine, Institute of Mental Health + Ministarstvo zdravlja Republike Srbije

e-mail: jmtmilov@eunet.rs

Abstract

Purpose: to assess symptoms of depression and to define its influence on quality of life (QOL) in patients with epilepsy. Method: Adult patients (age range 18-65 years) with normal intelligence and without any progressive neurological disease or psychotic disorder were included in the study. They completed Beck's Depression Inventory (BDI), Symptom Check List - 90 (SCL-90), Quality of life in epilepsy Inventory - 31 (QOLIE-31) - Serbian version, and Hamilton depressive scale, which was completed by investigator. Multiple regression analysis was performed to assess the predictive effects of depression scales scores on QOLIE- 31 total score. Results: 11.8% of patients had clinical diagnosis of depression and were previously treated with antidepressants. According to Beck's depression inventory, symptoms of depression were present in 33% of patients. Multiple regression analysis showed significant correlation between three instruments for depression: BDI, HAMD and SCL-90 depression score and overall score of QOLIE-31. 64% of overall score was determined by those scores (F=51.88; p<0.001; R2= 0.63). Tests of regression coefficients significance showed that only BDI score was significant predictor of QOLIE-31 (beta =-0.55; t=-5.17; p<0.001). All subscales of QOLIE- 31 were negatively and moderately correlated with instruments of depression (r=-0.334 to - 0.744). Conclusion: depression is frequently coexisting psychiatric condition in patients with epilepsy which has significant influence on QOL.

Keywords

References

American Psychiatric Association (1997) Diagnostic and Statistical Manual for Mental Disorders. Washington, DC: APA, 4th ed
Barraclough, B. (1981) Suicide and epilepsy. in: Reynolds E.H. i Trimble M.R. [ed.] Epilepsy and psychiatry, Edinburgh, itd: Churchill-Livingstone, 72-6
Baxendale, S.A., Thompson, P.J., Duncan, J.S. (2005) Epilepsy & depression: The effects of comorbidity on hippocampal volume: a pilot study. Seizure, 14(6): 435-8
Boylan, L.S., Flint, L.A., Labovitz, D.L., Jackson, S.C., Starner, K., Devinsky, O. (2004) Depression but not seizure frequency predicts quality of life in treatment-resistant epilepsy. Neurology, 62(2): 258-61
Chaplin, J.E., Yepez, R., Shorvon, S., Floyd, M. (1990) A quantitative approach to measuring the social effects of epilepsy. Neuroepidemiology, 9(3): 151-8
Craig, C., Oxley, J. (1988) Social aspects of epilepsy. in: Laidlaw J., Richens A., Oxley J. [ed.] A textbook of epilepsy, London: Churchill Livingstone, 3rd ed
Cramer, J.A., Perrine, K., Devinsky, O., Bryant-Comstock, L., Meador, K., Hermann, B. (1998) Development and cross-cultural translations of a 31-item quality of life in epilepsy inventory. Epilepsia, 39(1): 81-8
Cramer, J.A., Brandenburg, N., Xu, X. (2005) Differentiating anxiety and depression symptoms in patients with partial epilepsy. Epilepsy & behavior, 6(4): 563-9
Cramer, J.A., Blum, D., Reed, M., Fanning, K. (2003) The influence of comorbid depression on quality of life for people with epilepsy. Epilepsy & behavior, 4(5): 515-21
Dell, J.L. (1986) Social dimensions of epilepsy: Stigma and response. in: Whitman S., Hermann B.P. [ed.] Psychopathology in epilepsy: Social dimensions, New York: Oxford university press, p.85-210
Devillis, R.F., Devellis, B.M., Wallston, B.S., Wallston, K.A. (1980) Epilepsy and Learned Helplessness. Basic and Applied Social Psychology, 1(3): 241-253
Ettinger, A., Reed, M., Cramer, J. (2004) Depression and comorbidity in community-based patients with epilepsy or asthma. Neurology, 63(6): 1008-14
Gilliam, F.G., Santos, J., Vahle, V., Carter, J., Brown, K., Hecimovic, H. (2004) Depression and epilepsy: Ignoring clinical expression of neuronal network dysfunction?. Epilepsia, 45 (Suppl 2): 28-33
Gilliam, F. (2003) The impact of epilepsy on subjective health status. Current neurology and neuroscience reports, 3(4): 357-62
Gilliam, F., Kanner, A.M. (2002) Treatment of depressive disorders in epilepsy patients. Epilepsy & Behavior, 3(5): 2-9
Hermann, B.P., Seidenberg, M., Bell, B. (2000) Psychiatric comorbidity in chronic epilepsy: Identification, consequences, and treatment of major depression. Epilepsia, 41 Suppl 2: S31-41
Hermann, B.P., Whitman, S. (1989) Psychosocial predictors of interictal depression. Journal of Epilepsy, 2(4): 231-237
Hesdorffer, D.C., Hauser, W.A., Annegers, J.F., Cascino, G. (2000) Major depression is a risk factor for seizures in older adults. Annals of neurology, 47(2): 246-9
Hesdorffer, D.C., Hauser, A.W., Olafsson, E., Ludvigsson, P., Kjartansson, O. (2006) Depression and suicide attempt as risk factors for incident unprovoked seizures. Annals of neurology, 59(1): 35-41
Hesdorffer, D.C., Ludvigsson, P., Olafsson, E., Gudmundsson, G., Kjartansson, O., Hauser, A.W. (2004) ADHD as a risk factor for incident unprovoked seizures and epilepsy in children. Archives of general psychiatry, 61(7): 731-6
Hesdorffer, D.C., Lee, P. (2009) Health, wealth, and culture as predominant factors in psychosocial morbidity. Epilepsy & behavior, 15 Suppl 1: S36-40
Jacoby, A. (1994) Felt versus enacted stigma: A concept revisited. Evidence from a study of people with epilepsy in remission. Social science & medicine, 38(2): 269-74
Jobe, P.C., Weber, R.J. (2005) Comorbidity of neurological and affective disorders: The model of the genetically epilepsy-prone rat. in: Gilliam F., Kanner A.M., Sheline J.I. [ed.] Depression and the brain disfunction, London: Taylor and Francis, 121-57, medical books
Jobe, P.C., Browning, J.A. (2005) The serotonergic and noradrenergic effects of antidepressant drug are anticonvulsant, not proconvulsant. Epilepsy and behavior, 7(4); 609-19
Jobe, P.C., Dailey, J.W., Wernicke, J.F. (1999) A noradrenergic and serotonergic hypothesis of the linkage between epilepsy and affective disorders. Critical reviews in neurobiology, 13(4): 317-56
Jobe, P.C. (2003) Common pathogenetic mechanisms between depression and epilepsy: An experimental perspective. Epilepsy behave, 14-24, 4 (Suppl 3)
Johnson, E.K., Jones, J.E., Seidenberg, M., Hermann, B.P. (2004) The relative impact of anxiety, depression, and clinical seizure features on health-related quality of life in epilepsy. Epilepsia, 45(5): 544-50
Jones, J.E., Hermann, B.P., Barry, J.J., Gilliam, F.G., Kanner, A.M., Meador, K.J. (2003) Rates and risk factors for suicide, suicidal ideation and suicide attempts in chronic epilepsy. Epilepsy and behavior, 4 (Suppl 3): S31-S38
Jones, J.E., Hermann, B.P., Woodard, J.L., Barry, J.J., Gilliam, F., Kanner, A.M., Meador, K.J. (2005) Screening for Major Depression in Epilepsy with Common Self-report Depression Inventories. Epilepsia, 46(5): 731-735
Kanner, A.M. (2003) Depression in epilepsy: A frequently neglected multifaceted disorder. Epilepsy behave, 11-9, 4 (Suppl 4)
Kanner, A.M., Weisbrot, D.M. (2007) Psychiatric evaluation of the adult and pediatric patient with epilepsy. in: Ettinger A.B., Kanner A.M. [ed.] Psychiatric issues in epilepsy: A practical guide to diagnosis and treatment, Philadelphia: Lippincot Williams and Wilkins, p.119-132
Kanner, A.M. (2006) Epilepsy, suicidal behaviour, and depression: Do they share common pathogenic mechanisms?. Lancet Neurology, 5(2): 107-108
Kanner, A.M., Palac, S. (2000) Depression in Epilepsy: A Common but Often Unrecognized Comorbid Malady. Epilepsy & behavior, 1(1): 37-51
Kessler, R.C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K.R., Rush, J.A., Walters, E.E., Wang, P.S. (2003) The epidemiology of major depressive disorder: Results from the National Comorbidity Survey Replication (NCS-R). JAMA, 289(23): 3095-105
Kwan, P., Yu, E., Leung, H., Leon, T., Mychaskiw, M.A. (2009) Association of subjective anxiety, depression, and sleep disturbance with quality-of-life ratings in adults with epilepsy. Epilepsia, 50(5): 1059-66
Lehrner, J., Kalchmayr, R., Serles, W., Olbrich, A., Pataraia, E., Aull, S., Bacher, J., Leutmezer, F., Gröppel, G., Deecke, L., Baumgartner, C. (1999) Health-related quality of life (HRQOL), activity of daily living (ADL) and depressive mood disorder in temporal lobe epilepsy patients. Seizure, 8(2): 88-92
Loring, D.W., Meador, K.J., Lee, G.P. (2004) Determinants of quality of life in epilepsy. Epilepsy & Behavior, 5(6): 976-980
Martinović, Z., Milovanović, M., Tosković, O., Jovanović, M., Buder, N., Simonović, P., Dokić, R. (2010) Psychometric evaluation of the Serbian version of the Quality of Life in Epilepsy Inventory-31 (QOLIE-31). Seizure, 19(8): 517-24
Perrine, K., Hermann, B.P., Meador, K.J., Vickrey, B.G., Cramer, J.A., Hays, R.D., Devinsky, O. (1995) The relationship of neuropsychological functioning to quality of life in epilepsy. Archives of neurology, 52(10): 997-1003
Roth, D.L., Goode, K.T., Williams, V.L., Faught, E. (1994) Physical exercise, stressful life experience, and depression in adults with epilepsy. Epilepsia, 35(6): 1248-55
Şenol, V., Soyuer, F., Arman, F., Öztürk, A. (2007) Influence of fatigue, depression, and demographic, socioeconomic, and clinical variables on quality of life of patients with epilepsy. Epilepsy & Behavior, 10(1): 96-104
Timotijević-Marković, I., Paunović, V.R. (2003) Instrumenti kliničke procene u psihijatriji. Beograd: Institut za mentalno zdravlje
Tracy, J.I., Dechant, V., Sperling, M.R., Cho, R., Glosser, D. (2007) The association of mood with quality of life ratings in epilepsy. Neurology, 68(14): 1101-7
Zeber, J.E., Copeland, L.A., Amuan, M., Cramer, J.A., Pugh, M.J.V. (2007) The role of comorbid psychiatric conditions in health status in epilepsy. Epilepsy & behavior, 10(4): 539-46