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Srpski arhiv za celokupno lekarstvo
2013, vol. 141, br. 7-8, str. 560-564
jezik rada: srpski
vrsta rada: iskustva iz prakse
objavljeno: 13/11/2013
doi: 10.2298/SARH1308560D
Dijagnostika bakterijske vaginoze
aUniverzitet u Beogradu, Medicinski fakultet, Institut za mikrobiologiju i imunologiju
bUniverzitet u Beogradu, Medicinski fakultet, GAK 'Narodni front'
cUniverzitet u Beogradu, Medicinski fakultet, GAK 'Narodni front' + Univerzitet u Beogradu, Medicinski fakultet

e-adresa: bobadi@orion.rs

Sažetak

Bakterijska vaginoza je čest i složen klinički sindrom koji se odlikuje izmenom sastava vaginalne flore. Kada je simptomatske prirode, odlikuje se pojačanim vaginalnim sekretom neprijatnog mirisa i ponekad znacima iritacije vaginalne sluzokože. Kod žena normalne vaginalne flore laktobacili čine predominantnu bakterijsku floru. Bakterijska vaginoza dovodi do značajnog smanjenja laktobacila koji stvaraju H2O2 i predominacije anaerobnih vrsta bakterija, Gardnerella vaginalis, Atopobium vaginae, Mycoplasma hominis i Mobiluncus species. Najveći broj bakterijskih infekcija dijagnostikuje se kultivisanjem uzorka, otkrivanjem specifičnih antigena ili nukleinskih kiselina bakterija, ili nekom serološkom metodom koje otkrivaju prisustvo specifičnih antitela. Prepoznavanje bakterijske vrste u uzorku je najčešće neophodan kriterijum za dijagnostikovanje infekcije. Navedeno ne važi za dijagnostiku bakterijske vaginoze s obzirom na to da ne postoji jedan etiološki agens odgovoran za njen nastanak. Iako postoje klinički i mikrobiološki dijagnostički kriterijumi, još nema tzv. zlatnog standarda za komparaciju i precizno dijagnostikovanje ovog sindroma. Dijagnostika bakterijske vaginoze dugo se postavljala na osnovu kliničkih Amselovih (Amsel) kriterijuma, a nešto kasnije uvedena je Nudžentova (Nugent) metoda, koja se danas rutinski najviše koristi. Savremene molekularne metode se uvode u dijagnostiku vaginoze, a bolje poznavanje patogeneze ovoga sindroma svakako je neophodno za definisanje metode koja bi bila najbolja u otkrivanju svih slučajeva bakterijske vaginoze.

Ključne reči

Reference

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