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Vojnosanitetski pregled
2002, vol. 59, br. 5, str. 499-506
jezik rada: srpski
vrsta rada: stručni članak
doi:10.2298/VSP0205499M
Rezistencija bolničkih sojeva Enterococcus faecalis i Enterococcus faecium na antibiotike
Vojnomedicinska akademija

Sažetak

Cilj ovoga rada bio je da se utvrdi rezistencija bolničkih sojeva Enterococcus faecalis (E. faecalis) i Enterococcus faecium (E. faecium) izolovanih tokom 1999. godine na penicilin, ampicilin, vankomicin, teikoplanin, gentamicin (visok nivo rezistencije), streptomicin (visok nivo rezistencije), oksitetraciklin, hloramfenikol, rifampin, eritromicin, ciprofloksacin, norfloksacin i nitrofurantoin. Rezistencija enterokoka na antibiotike utvrđena je disk-difuzionim i dilucionim metodama prema preporukama američkog Nacionalnog komiteta za kliničke laboratorijske standarde (NCCLS). Produkcija beta-laktamaza utvrđena je pomoću diskova nitrocefina. U izolatima E. faecalis (n=111) i E. faecium (n=48) učestalost rezistencije, istovremeno, na oba penicilina (penicilin i ampicilin) bila je 0,9%, odnosno 89,6%. Svi izolati enterokoka bili su beta-laktamaza negativni. Samo jedan soj E. faecium bio je rezistentan na vankomicin (Van A fenotip). Među izolatima E. faecalis (n=109) učestalost rezistencije visokog nivoa na gentamicin (RVNG), rezistencije visokog nivoa na streptomicin (RVNS) i na oba agensa bila je 52,3%, 50,4% i 43,7%. U izolatima E. faecium (n=48) RVNG, RVNS i na oba agensa bila je 68,7%, 75% i 62,5%. Većina izolata E. faecium bila je rezistentna na penicilin i ampicilin. E. faecalis je bio osetljiv na peniciline. Učestalost enterokoka koje ispoljavaju rezistenciju visokog nivoa na aminoglikozide je veoma visoka.

Ključne reči

Reference

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