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Zdravstvena zaštita
2012, vol. 41, iss. 4, pp. 61-65
article language: Serbian
document type: Professional Paper

Oxidative stress in acute and chronic physical exercise athletes
Visoka medicinska škola strukovnih studija 'Milutin Milanković', Beograd


Background. Oxidative stress means the state of increased free radical production where their harmful effects overwhelm the antioxidant capacity of an organism and lead to a number of pathological disorders. Oxidative stress is basically a number of diseases: atherosclerosis and rheumatoid arthritis, amyotrophic lateral sclerosis, cataract surgery, the heart attacks, cancer, the aging process. Factors in the environment, toxic chemicals, ionizing radiation, excess heavy metals, cigarette smoking, physical activity can increase the production of free radicals. The organism has developed antioxidative protection that includes protection of enzymatic (superoxide dismutase, catalase, glutathione peroxidase). This protection includes a number of antioxidant compounds that living organisms take from the environment. In a paper published in Journal of Sports Medicine Fitness Fis, Dec. 2011., studied the effect of acute physical exercise on oxidative stress and antioxidant enzymes before and after the match with 22 players of American football. The results showed that a match caused excessive production of free radicals (malondialdehyde and nitric oxide), and the parameters of antioxidant defense, glutathione peroxidase (GPx) and superoxide dismutase (SOD), have remained unchanged. It was concluded that the antioxidant protection to be effective it is necessary that the physical load takes a long time and that the higher intensity. In a study published in Int J. Sport Nutr Exerc Metab, Aug. 2010., followed by the chronic effects of exercise in gymnastics - and adolescents in the control group of preadolescent girls that do not play sports. Over 3 years were observed in serum concentrations of antioxidant enzymes,GPx and SOD and trace elements (selenium, zinc, copper). The concentrations of GPx and trace elements were significantly higher in gymnasts than in controls, whereas SOD concentrations were significantly lower in gymnasts than in controls. When gymnasts were altered profile of antioxidant enzymes compared to their physically inactive peers. In athletes with longer periods of exercise developed more effective antioxidant protection. Discussion. Athletes, especially elite athletes, are subjected to enormous stress both during training and especially during the contest. Acute physical exertion can lead to oxidative tissue damage that could be avoided by using antioxidant professional resources. In chronic physical exercise leads to increased oxidative stress markers but important changes, and antioxidant protection that is becoming more efficient. Conclusion. Harmful effects of free radicals in acute physical exercise may be decrease antioxidant substances. Planned and professionally managed chronic physical activity leads to improved antioxidant protection of organism.



*** (2002) Droge. Wulf Free Radicals in the Physiological Control of Cell Function. Physiological Reviews, January vol. 82, br. 1, str. 47-95., 10.1152/physrev.00018.2001, abstract Posećeno: 19.septembar 2010
Alshammari, E., Shafi, S., Nurmi-Lawton, J., Taylor, A. (2010) Altered antioxidant and trace-element status in adolescent female gymnasts. Journal Int Sport Nutr Exerc Metab, 20 (4): 291-298
Darley-Usmar, V., Halliwell, B. (1996) Blood radicals: Reactive nitrogen species, reactive oxygen species, transition metal ions, and the vascular system. Pharm Res, 13(5): 649-62
Đukić, M. (2005) Oksidativni stres - slobodni radikali, prooksidansi, antioksidansi. Mono&Manjana
Emerit, I. (1994) Reactive oxygen species, chromosome mutation, and cancer: Possible role of clastogenic factors in carcinogenesis. Free Radic Biol Med, 16(1): 99-109
Ferreira, A.R., Bonatto, F., de Bittencourt, P.M.A., Polydoro, M., Dal-Pizzol, F., Fernández, C., de Salles, A.A.A., Moreira, J.C.F. (2006) Oxidative stress effects on the central nervous system of rats after acute exposure to ultra high frequency electromagnetic fields. Bioelectromagnetics, 27(6): 487-93
Finaud, J., Lac, G., Filaire, E. (2006) Oxidative stress: Relationship with exercise and training. Sports Medicine, 36(4): 327
Halliwell, B. (1987) Oxidants and human disease: Some new concepts. FASEB J, 1(5): 358-64
Höytö, A., Luukkonen, J., Juutilainen, J., Naarala, J. (2008) Proliferation, Oxidative Stress and Cell Death in Cells Exposed to 872 MHz Radiofrequency Radiation and Oxidants. Radiation Research, 170(2): 235-243
Iorio, E.L. (2004) d-ROMs test in sport. Cosmetic News, 157: 272-75
Iorio, E.L. (2005) Oxidative stress, sport trauma and rehabilitation: New proposals for an integrated approach. in: International congress on sports rehabilitation and traumatology (XIV), Bologna, Italy, Proceedings, str. 127
Nalcakan, R.G., Nalcakan, M., Var, A., Taneli, F., Ulman, C., Guvenc, Y., Onur, E., Karamizrak, O. (2011) Acute oxidative stress and antioxidant status responses following an American football match. Journal Sports Med Fis fitnes, Dec; 51(3); 533-9
Pešić, S., Jakovljević, V., Čubrilo, D., Živković, V., Jorga, V., Mujović, V., Stojimirović, B. (2009) Evaluacija oksidativnog statusa kod vrhunskih sportista-karatista u procesu treninga. Vojnosanitetski pregled, vol. 66, br. 7, str. 551-555
Sies, H. (1985) Oxidative stress: Introductory remarks. New York: Academic Press, In: Sies H
Simić, M.G., Taylor, K.A. (1988) Introduction to peroxydation and antioxidation mechanisms. in: Oxygen radicals in biology and medicine, New York-London: Plenum press, 1-90
Spasić, S., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V. (2003) Medicinska biohemija. Beograd
Todorović, T., Stojanović, T., Babić, M. (2002) Osnovi medicinske biohemije - za studente stomatologije. Beograd: Stručna knjiga
Živković, M. (1998) Hiperbarična i podvodna medicina. Beograd: Nauka