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Vojnosanitetski pregled
2010, vol. 67, br. 3, str. 203-208
jezik rada: srpski
vrsta rada: originalan članak
doi:10.2298/VSP1003203S
Blink i maseter inhibitorni refleks kod Parkinsonove bolesti
Klinički centar Niš, Klinika za neurologiju, Niš

e-adresa: j.stamenovic@yahoo.com

Sažetak

Uvod/Cilj. Idiopatska Parkinsonova bolest (PB) je hronično, progresivno, neurodegenerativno oboljenje sa prevalencijom od 60 do 187 na 100 000 stanovnika u opštoj populaciji. Cilj rada bio je utvrđivanje abnormalnosti blink refleksa (BR) i maseter inhibitornog refleksa (MIR) kod obolelih od PB, kao pokazatelja funkcijskog statusa mreže neurona moždanog stabla, i zavisnosti stepena abnormalnosti od progresije bolesti. Metode. Istraživanje je obavljeno u Klinici za neurologiju, Kliničkog centra u Nišu, u grupi od 60 osoba oba pola, obolelih od idiopatske PB u I-IV stadijumu bolesti, prema skali Hoehn-ove i Yahr-a. U kontrolnoj grupi bilo je 30 zdravih osoba oba pola, odgovarajućeg životnog doba. Testiranje bolesnika obavljeno je u 'on' fazi, registracijom MIR i BR. Rezultati. Latencije polisinaptičkih R2 i R2' odgovora blink refleksa i latencije polisinaptičkog S2 odgovora i perioda tišine maseter inhibitornog refleksa skraćuju se linearno kod bolesnika sa PB, izraženije u kasnijim stadijumima bolesti, u odnosu na kontrolnu grupu. Zaključak. Postoji pozitivna korelacija između rezultata primenjenih neurofizioloških testova i kliničkog stadijuma PB.

Ključne reči

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