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Srpski arhiv za celokupno lekarstvo
2014, vol. 142, br. 5-6, str. 286-290
jezik rada: engleski
vrsta rada: originalan članak
doi:10.2298/SARH1406286M


Promene u parametrima retrobulbarne cirkulacije nakon snižavanja povišenog intraokularnog pritiska kod osoba s primarnim glaukomom otvorenog ugla
aSchool of Medicine, Belgrade + Eye Clinic, Clinical Center of Serbia, Belgrade
bInstituto Gallego de Oftalmologia, Clinical Research Department, Science Research and Sports, Santiago de Compostela, La Coruna, Spain
cSchool of Medicine, Belgrade + Cardiology Clinic, Clinical Center of Serbia, Belgrade
dUniverzitet u Beogradu, Medicinski fakultet, Institut za medicinsku statistiku i informatiku

e-adresa: ivanmarjanovic007@yahoo.com

Sažetak

Uvod Poremećaj protoka krvi u oku može biti uključen kako u patogenezu, tako i u progresiju glaukomnog oštećenja. Cilj rada Cilj rada je bio da se uporede parametri retrobulbarne hemodinamike u oftalmičkoj arteriji (OA), centralnoj retinalnoj arteriji (CRA) i kratkim zadnjim cilijarnim arterijama (SPCA) nakon snižavanja povišenog intraokularnog pritiska (IOP) kod osoba s primarnim glaukomom otvorenog ugla (POAG) primenom kolor doplera. Metode rada Ispitano je 60 bolesnika (21 muškarac i 39 žena) sa dijagnostikovanim i lečenim POAG. Kod 39 ispitanika ustanovljen je povišen IOP (>25 mm Hg). Parametri vršnog sistolnog protoka, krajnjeg dijastolnog protoka, Purseloov (Pourcelot) indeks rezistencije i indeks pulzatilnosti mereni su u OA, CRA i SPCA. IOP je meren Goldmanovim (Goldmann) aplanacionim tonometrom (GAT) i dinamičkim konturnim tonometrom (DCT), po tri puta uzastopno. Okularna pulsna amplituda (OPA) je merena pomoću DCT. Rezultati Parametri retrobulbarne cirkulacije se nisu promenili posle snižavanja IOP. Nakon Bonferonijeve (Bonferroni) korekcije (p≤0,0056, α/9) statistički značajna razlika u retrobulbarnim parametrima je utvrđena kod onih merenih pomoću DCT (29,8±6,2 prema 15,5±5,0), GAT (33,8±9,0 prema 15,0±6,6) i kod OPA (4,3±1,0 prema 3,0±1,6), u poređenju s početnim vrednostima. Nije uočena korelacija između promena IOP koji je meren pomoću DCT ili GAT i promena u hemodinamskim parametrima (p>0,05 za sve). Pirsonov koeficijent korelacije (95-procentni interval poverenja) pokazao je veoma dobru korelaciju za vrednosti IOP između onih dobijenih merenjem pomoću DCT i onih izmerenih primenom GAT: početna vrednost u proseku je bila 0,83 (raspon 0,71-0,90), a završna 0,71 (raspon 0,55-0,83); p<0,0001 za oba merenja i bez razlike među njima (p>0,05). Zaključak Nije utvrđena korelacija između razlika u IOP merenih pomoću DCT ili GAT i promena u posmatranim hemodinamskim parametrima.

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Reference

Asman, P., Heijl, A. (1992) Glaucoma Hemifield Test. Automated visual field evaluation. Archives of ophthalmology (Chicago, Ill. : 1960), 110(6): 812-9
Carter, C.J., Brooks, D.E., Doyle, D. L., Drance, S.M. (1990) Investigations into a Vascular Etiology for Low-tension Glaucoma. Ophthalmology, 97(1): 49-55
Findl, O., Strenn, K., Wolzt, M., Menapace, R., Vass, C., Eichler, H.G., Schmetterer, L. (1997) Effects of changes in intraocular pressure on human ocular haemodynamics. Current eye research, 16(10): 1024-9
Flammer, J., Orgül, S., Costa, V.P., Orzalesi, N., Krieglstein, G.K., Metzner, S.L., i dr. (2004) The impact of ocular blood flow in glaucoma. Prog Retin Eye Res, 21(4), str. 359-93
Galassi, F., Sodi, A., Ucci, F., Renieri, G., Pieri, B., Baccini, M. (2003) Ocular hemodynamics and glaucoma prognosis: a color Doppler imaging study. Archives of ophthalmology (Chicago, Ill. : 1960), 121(12): 1711-5
Harris, A., Kagemann, L., Ehrlich, R., Rospigliosi, C., Moore, D., Siesky, B. (2008) Measuring and interpreting ocular blood flow and metabolism in glaucoma. Canadian journal of ophthalmology, 43(3): 328-36
Hayreh, S.S. (1994) Progress in the understanding of the vascular etiology of glaucoma. Current Opinion in Ophthalmology, 5(2): 26-35
Lieb, W.E. (1993) Color Doppler ultrasonography of the eye and orbit. Current opinion in ophthalmology, 4(3): 68-75
Lieb, W.E., Cohen, S.M., Merton, D.A., Shields, J.A., Mitchell, D.G., Goldberg, B.B. (1991) Color Doppler imaging of the eye and orbit. Technique and normal vascular anatomy. Archives of ophthalmology (Chicago, Ill. : 1960), 109(4): 527-31
Marjanovic, I., Milic, N., Martinez, A., Benitez-del-Castillo, J. (2012) Retrobulbar hemodynamic parameters in open-angle and angle-closure glaucoma patients. Eye (London, England), 26(4): 523-8
Marjanovic, I., Milic, N., Martinez, A. (2012) The impact of intraocular pressure reduction on retrobulbar hemodynamic parameters in patients with open-angle glaucoma. European journal of ophthalmology, 22(1): 77-82
Martinez, A., Gonzalez, F., Capeans, C., Perez, R., Sanchez-Salorio, M. (1999) Dorzolamide effect on ocular blood flow. Investigative Ophthalmology and Visual Science, 40(6): 1270-5
Martinez, A., Sanchez, M. (2008) Effects of dorzolamide 2% added to timolol maleate 0.5% on intraocular pressure, retrobulbar blood flow, and the progression of visual field damage in patients with primary open-angle glaucoma: A single-center, 4-year, open-label study. Clinical Therapeutics, 30(6): 1120-1134
Martinez, A., Sanchez, M. (2008) Ocular haemodynamics in pseudoexfoliative and primary open-angle glaucoma. Eye (London, England), 22(4): 515-20
Martínez, A., Sánchez, M. (2006) A comparison of the effects of 0.005% latanoprost and fixed combination dorzolamide/timolol on retrobulbar haemodynamics in previously untreated glaucoma patients. Current medical research and opinion, 22(1): 67-73
Martínez, A., Sánchez, M. (2005) Predictive value of colour Doppler imaging in a prospective study of visual field progression in primary open-angle glaucoma. Acta ophthalmologica Scandinavica, 83(6): 716-22
Pourcelot, L. (1975) Indications of Doppler's ultrasonography in the study of peripheral vessels. La Revue du praticien, 25(59): 4671-80
Satilmis, M., Orgül, S., Doubler, B., Flammer, J. (2003) Rate of progression of glaucoma correlates with retrobulbar circulation and intraocular pressure. American Journal of Ophthalmology, 135(5): 664-9
Trible, J.R., Sergott, R.C., Spaeth, G.L., Wilson, R.P., Katz, L.J., Moster, M.R., Schmidt, C.M. (1994) Trabeculectomy is associated with retrobulbar hemodynamic changes. A color Doppler analysis. Ophthalmology, 101(2): 340-51
Werne, A., Harris, A., Moore, D., BenZion, I., Siesky, B. (2008) The circadian variations in systemic blood pressure, ocular perfusion pressure, and ocular blood flow: risk factors for glaucoma?. Survey of ophthalmology, 53(6): 559-67
Zeitz, O., Galambos, P., Wagenfeld, L., Wiermann, A., Wlodarsch, P., Praga, R., Matthiessen, E.T., Richard, G., Klemm, M. (2006) Glaucoma progression is associated with decreased blood flow velocities in the short posterior ciliary artery. British journal of ophthalmology, 90(10): 1245-8