Article metrics

  • citations in SCindeks: 0
  • citations in CrossRef:0
  • citations in Google Scholar:[=>]
  • visits in previous 30 days:0
  • full-text downloads in 30 days:0
article: 2 from 3  
Back back to result list
Srpski arhiv za celokupno lekarstvo
2014, vol. 142, iss. 5-6, pp. 286-290
article language: English
document type: Original Paper
doi:10.2298/SARH1406286M


Changes in the retrobulbar hemodynamic parameters after decreasing the elevated intraocular pressure in primary open-angle glaucoma patients
aSchool of Medicine, Belgrade + Eye Clinic, Clinical Center of Serbia, Belgrade
bInstituto Gallego de Oftalmologia, Clinical Research Department, Science Research and Sports, Santiago de Compostela, La Coruna, Spain
cSchool of Medicine, Belgrade + Cardiology Clinic, Clinical Center of Serbia, Belgrade
dUniverzitet u Beogradu, Medicinski fakultet, Institut za medicinsku statistiku i informatiku

e-mail: ivanmarjanovic007@yahoo.com

Abstract

Introduction Ocular blood flow (OBF) disturbances could be involved both in the pathogenesis and in progression of glaucomatous damage. Objective The aim of the study was to compare the retrobulbar hemodynamic parameters in the ophthalmic artery (OA), central retinal artery (CRA) and short posterior cilliary arteries (SPCA) after decreasing the elevated intraocular pressure (IOP) in primary open-angle glaucoma (POAG) patients by using color Doppler imaging (CDI). Methods We examined 60 patients (21 male and 39 female) with diagnosed and treated POAG. Thirtynine patients had increased IOP (>25 mm Hg). Peak-systolic velocity (PSV), end-diastolic velocity (EDV), Pourcelot resistance index (RI), and pulsatility index (PI) were assessed in the OA, CRA, and SPCA. IOP was measured both with the Goldmann Applanation tonometer (GAT) and with the Dynamic Contour tonometer (DCT), three times respectively. Ocular pulse amplitude (OPA) was measured using DCT. Results The retrobulbar parameters between the baseline and after IOP reduction showed no difference in measurements. After Bonferroni correction (p≤0.0056, alpha/9) statistical significance was recorded only in the following retrobulbar hemodynamic parameters; DCT (29.8 ±6.2 vs. 15.5±5.0), GAT (33.8±9.0 vs. 15.0±6.6) and OPA measurements (4.3±1.0 vs. 3.0±1.6), as compared to the baseline. There was no correlation between the changes in IOP measured with either DCT or GAT and changes in the hemodynamic parameters (p>0.05 for all). Pearson correlation coefficient (95% CI) showed very good correlation for IOP measurements between DCT and GAT: at baseline 0.83 (0.71 to 0.90) and at the end 0.71 (0.55 to 0.83); p<0.0001 for both measurements, but without any difference between them (p>0.05). Conclusion There was a lack of correlation between the changes in IOP measured with either DCT or GAT and the changes in the hemodynamic parameters.

Keywords

References

Asman, P., Heijl, A. (1992) Glaucoma Hemifield Test. Automated visual field evaluation. Archives of ophthalmology (Chicago, Ill. : 1960), 110(6): 812-9
Carter, C.J., Brooks, D.E., Doyle, D. L., Drance, S.M. (1990) Investigations into a Vascular Etiology for Low-tension Glaucoma. Ophthalmology, 97(1): 49-55
Findl, O., Strenn, K., Wolzt, M., Menapace, R., Vass, C., Eichler, H.G., Schmetterer, L. (1997) Effects of changes in intraocular pressure on human ocular haemodynamics. Current eye research, 16(10): 1024-9
Flammer, J., Orgül, S., Costa, V.P., Orzalesi, N., Krieglstein, G.K., Metzner, S.L., i dr. (2004) The impact of ocular blood flow in glaucoma. Prog Retin Eye Res, 21(4), str. 359-93
Galassi, F., Sodi, A., Ucci, F., Renieri, G., Pieri, B., Baccini, M. (2003) Ocular hemodynamics and glaucoma prognosis: a color Doppler imaging study. Archives of ophthalmology (Chicago, Ill. : 1960), 121(12): 1711-5
Harris, A., Kagemann, L., Ehrlich, R., Rospigliosi, C., Moore, D., Siesky, B. (2008) Measuring and interpreting ocular blood flow and metabolism in glaucoma. Canadian journal of ophthalmology, 43(3): 328-36
Hayreh, S.S. (1994) Progress in the understanding of the vascular etiology of glaucoma. Current Opinion in Ophthalmology, 5(2): 26-35
Lieb, W.E. (1993) Color Doppler ultrasonography of the eye and orbit. Current opinion in ophthalmology, 4(3): 68-75
Lieb, W.E., Cohen, S.M., Merton, D.A., Shields, J.A., Mitchell, D.G., Goldberg, B.B. (1991) Color Doppler imaging of the eye and orbit. Technique and normal vascular anatomy. Archives of ophthalmology (Chicago, Ill. : 1960), 109(4): 527-31
Marjanovic, I., Milic, N., Martinez, A., Benitez-del-Castillo, J. (2012) Retrobulbar hemodynamic parameters in open-angle and angle-closure glaucoma patients. Eye (London, England), 26(4): 523-8
Marjanovic, I., Milic, N., Martinez, A. (2012) The impact of intraocular pressure reduction on retrobulbar hemodynamic parameters in patients with open-angle glaucoma. European journal of ophthalmology, 22(1): 77-82
Martinez, A., Gonzalez, F., Capeans, C., Perez, R., Sanchez-Salorio, M. (1999) Dorzolamide effect on ocular blood flow. Investigative Ophthalmology and Visual Science, 40(6): 1270-5
Martinez, A., Sanchez, M. (2008) Effects of dorzolamide 2% added to timolol maleate 0.5% on intraocular pressure, retrobulbar blood flow, and the progression of visual field damage in patients with primary open-angle glaucoma: A single-center, 4-year, open-label study. Clinical Therapeutics, 30(6): 1120-1134
Martinez, A., Sanchez, M. (2008) Ocular haemodynamics in pseudoexfoliative and primary open-angle glaucoma. Eye (London, England), 22(4): 515-20
Martínez, A., Sánchez, M. (2006) A comparison of the effects of 0.005% latanoprost and fixed combination dorzolamide/timolol on retrobulbar haemodynamics in previously untreated glaucoma patients. Current medical research and opinion, 22(1): 67-73
Martínez, A., Sánchez, M. (2005) Predictive value of colour Doppler imaging in a prospective study of visual field progression in primary open-angle glaucoma. Acta ophthalmologica Scandinavica, 83(6): 716-22
Pourcelot, L. (1975) Indications of Doppler's ultrasonography in the study of peripheral vessels. La Revue du praticien, 25(59): 4671-80
Satilmis, M., Orgül, S., Doubler, B., Flammer, J. (2003) Rate of progression of glaucoma correlates with retrobulbar circulation and intraocular pressure. American Journal of Ophthalmology, 135(5): 664-9
Trible, J.R., Sergott, R.C., Spaeth, G.L., Wilson, R.P., Katz, L.J., Moster, M.R., Schmidt, C.M. (1994) Trabeculectomy is associated with retrobulbar hemodynamic changes. A color Doppler analysis. Ophthalmology, 101(2): 340-51
Werne, A., Harris, A., Moore, D., BenZion, I., Siesky, B. (2008) The circadian variations in systemic blood pressure, ocular perfusion pressure, and ocular blood flow: risk factors for glaucoma?. Survey of ophthalmology, 53(6): 559-67
Zeitz, O., Galambos, P., Wagenfeld, L., Wiermann, A., Wlodarsch, P., Praga, R., Matthiessen, E.T., Richard, G., Klemm, M. (2006) Glaucoma progression is associated with decreased blood flow velocities in the short posterior ciliary artery. British journal of ophthalmology, 90(10): 1245-8