Metrika članka

  • citati u SCindeksu: 0
  • citati u CrossRef-u:0
  • citati u Google Scholaru:[=>]
  • posete u poslednjih 30 dana:1
  • preuzimanja u poslednjih 30 dana:0
članak: 3 od 3  
Back povratak na rezultate
Srpski arhiv za celokupno lekarstvo
2011, vol. 139, br. 11-12, str. 718-721
jezik rada: engleski
vrsta rada: originalan članak
doi:10.2298/SARH1112718M


Promene u retrobulbarnoj arterijskoj cirkulaciji nakon smanjenja povišenog intraokularnog pritiska kod osoba s primarnim glaukomom otvorenog ugla
aKlinika za očne bolesti, Klinički centar Srbije, Beograd
bKlinika za neurologiju, Klinički centar Srbije, Beograd

e-adresa: ivanmarjanovic007@yahoo.com

Sažetak

Uvod. Poremećena perfuzija glave očnog živca je patogenetski faktor kod glaukoma. Cilj rada. Cilj rada bio je da se ustanovi kako se menjaju hemodinamski parametri u retrobulbarnoj arterijskoj cirkulaciji nakon smanjenja povišenog intraokularnog pritiska (IOP) kod pacijenata s primarnim glaukomom otvorenog ugla. Metode rada. Istraživanje je obuhvatilo 26 ispitanika (14 muškaraca i 12 žena), od kojih je 21 pacijent bio stariji od 50 godina, sa prethodno dijagnostikovanim i lečenim primarnim glaukomom otvorenog ugla. Svi pacijenti su pregledani na Klinici za očne bolesti KCS. Pored merenja IOP Goldmanovim (Goldmann) aplanacionim tonometrom (GAT), odnosno dinamičkim konturnim tonometrom (DCT), ispitanicima je izmerena i centralna debljina rožnjače ultrazvučnim pahimetrom. Pregled retrobulbarne arterijske cirkulacije kolor doplerom obavljen je na Klinici za neurologiju KCS. On je obuhvatio hemodinamske promene u oftalmičkoj arteriji, centralnoj retinalnoj arteriji i zadnjim cilijarnim arterijama. Posmatrani su sledeći parametri: vršni sistolni volumen (PSV), završni dijastolni volumen (EDV), indeks rezistencije (RI) i indeks pulsatilnosti (PI). Rezultati. Hemodinamski arterijski parametri PSV i EDV u oftalmičkoj i centralnoj retinalnoj arteriji nakon smanjenja IOP su se smanjili, dok su se RI i PI povećali. Kod kratkih zadnjih cilijarnih arterija PSV, EDV i PI su se smanjili, dok se RI povećao. Zaključak. Promene u retrobulbarnoj arterijskoj cirkulaciji tokom povećanja IOP kod osoba s primarnim glaukomom otvorenog ugla značajne su za pristup i lečenje, dok uloga vaskularnih faktora u ishrani neuroretinalnog oboda glave očnog živca može biti ključ u usporavanju progresije glaukoma i osnova neuroprotekcije.

Ključne reči

Reference

Agarwal, H.C., Gupta, V., Sihota, R., Singh, K. (2003) Pulsatile ocular blood flow among normal subjects and patients with high tension glaucoma. Indian journal of ophthalmology, 51(2): 133-8
Akarsu, C., Bilgili, Y.K.M. (2004) Color Doppler imaging in ocular hypertension and open-angle glaucoma. Graefe's archive for clinical and experimental ophthalmology / Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie, 242(2): 125-9
Baxter, G.M., Williamson, T.H., McKillop, G., Dutton, G.N. (1992) Color Doppler ultrasound of orbital and optic nerve blood flow: effects of posture and timolol 0.5%. Investigative ophthalmology & visual science, 33(3): 604-10
Butt, Z., O'Brien, C., McKillop, G., Aspinall, P., Allan, P. (1997) Color Doppler imaging in untreated high- and normal-pressure open-angle glaucoma. Invest Ophthalmol Vis Sci, 38(3): 690-6
Cioffi, G., Alm, A. (2001) Measurement of ocular blood flow. J Glaucoma, 10(Suppl): 62-4
Flammer, J., Orgül, S., Costa, V.P., Orzalesi, N., Krieglstein, G.K., Metzner, S.L., i dr. (2004) The impact of ocular blood flow in glaucoma. Prog Retin Eye Res, 21(4), str. 359-93
Flammer, J., Orgul, S. (1998) Optic nerve blood-flow abnormalities in glaucoma. Progress in Retinal and Eye Research, 17(2): 267-289
Galassi, F., Nuzzaci, G., Sodi, A., Casi, P., Vielmo, A. (1992) Color Doppler imaging in evaluation of optic nerve blood supply in normal and glaucomatous subjects. International ophthalmology, 16(4-5): 273-6
Harris, A., Williamson, T.H., Martin, B., Shoemaker, J.A., Sergott, R.C., Spaeth, G.L., Katz, J.L. (1995) Test/Retest reproducibility of color Doppler imaging assessment of blood flow velocity in orbital vessels. Journal of glaucoma, 4(4): 281-6
Harris, A., Jonescu-Cuypers, C.P. (2001) The impact of glaucoma medication on parameters of ocular perfusion. Current opinion in ophthalmology, 12(2): 131-7
Harris, A., Chung, H.S., Ciulla, T.A., Kagemann, L. (1999) Progress in measurement of ocular blood flow and relevance to our understanding of glaucoma and age-related macular degeneration. Progress in retinal and eye research, 18(5): 669-87
Joos, K.M., Kay, M.D., Pillunat, L.E., Harris, A., Gendron, E.K., Feuer, W.J., Steinwand, B.E. (1999) Effect of acute intraocular pressure changes on short posterior ciliary artery haemodynamics. British journal of ophthalmology, 83(1): 33-8
Kaiser, H.J., Schoetzau, A., Stümpfig, D., Flammer, J. (1997) Blood-flow velocities of the extraocular vessels in patients with high-tension and normal-tension primary open-angle glaucoma. American journal of ophthalmology, 123(3): 320-7
Lieb, W.E., Cohen, S.M., Merton, D.A., Shields, J.A., Mitchell, D.G., Goldberg, B.B. (1991) Color Doppler imaging of the eye and orbit. Technique and normal vascular anatomy. Archives of ophthalmology, 109(4): 527-31
Nicolela, M.T., Walman, B.E., Buckley, A.R., Drance, S.M. (1996) Ocular hypertension and primary open-angle glaucoma: a comparative study of their retrobulbar blood flow velocity. Journal of glaucoma, 5(5): 308-10
Onda, E., Cioffi, G.A., Bacon, D.R., van Buskirk, E.M. (1995) Microvasculature of the human optic nerve. American journal of ophthalmology, 120(1): 92-102
Planiol, T., Pourcelot, L., Pottier, J.M., Degiovanni, E. (1972) Study of carotid circulation by means of ultrasonic methods and thermography. Revue neurologique, 126(2): 127-41
Punjabi, O.S., Ho, H.V., Kniestedt, C., Bostrom, A.G., Stamper, R.L., Lin, S.C. (2006) Intraocular pressure and ocular pulse amplitude comparisons in different types of glaucoma using dynamic contour tonometry. Current eye research, 31(10): 851-62
Satilmis, M., Orgül, S., Doubler, B., Flammer, J. (2003) Rate of progression of glaucoma correlates with retrobulbar circulation and intraocular pressure. American journal of ophthalmology, 135(5): 664-9
Schmidt, K.G., von Rückmann, A.V., Mittag, T.W., Hessemer, V., Pillunat, L.E. (1997) Reduced ocular pulse amplitude in low tension glaucoma is independent of vasospasm. Eye (Lond), 11(Pt 4), str. 485-8
Schwenn, O., Troost, R., Vogel, A., Grus, F., Beck, S., Pfeiffer, N. (2002) Ocular pulse amplitude in patients with open angle glaucoma, normal tension glaucoma, and ocular hypertension. British journal of ophthalmology, 86(9): 981-4
Simon, J., Rankin, A. (1999) Color Doppler imaging of the retrobulbar circulation in glaucoma. Surv Ophthalmol, 43(Suppl 1):S176-82
Williamson, T.H., Harris, A. (1996) Color Doppler ultrasound imaging of the eye and orbit. Survey of ophthalmology, 40(4): 255-67
Williamson, T.H., Lowe, G.D., Baxter, G.M. (1995) Influence of age, systemic blood pressure, smoking, and blood viscosity on orbital blood velocities. Br J Ophthalmol, 79(1): 17-22