Article metrics

  • citations in SCindeks: 0
  • citations in CrossRef:0
  • citations in Google Scholar:[=>]
  • visits in previous 30 days:2
  • full-text downloads in 30 days:1
article: 3 from 3  
Back back to result list
Srpski arhiv za celokupno lekarstvo
2011, vol. 139, iss. 11-12, pp. 718-721
article language: English
document type: Original Paper
doi:10.2298/SARH1112718M


Changes in the retrobulbar arterial circulation after decrease of elevated intraocular pressure in patients with primary open angle glaucoma
aKlinika za očne bolesti, Klinički centar Srbije, Beograd
bKlinika za neurologiju, Klinički centar Srbije, Beograd

e-mail: ivanmarjanovic007@yahoo.com

Abstract

Introduction. An altered perfusion of the optic nerve head has been proposed as a pathogenic factor in glaucoma. Objective. To evaluate changes of haemodynamic parameters in the retrobulbar arterial circulation after a decrease of elevated intraocular pressure (IOP) in patients with primary open angle glaucoma (POAG). Methods. Twenty-six patients were examined, 14 men and 12 women, 21 up to 50 years old and 5 below, all with previously diagnosed and treated POAG, and all examined at the Eye Clinic, Clinical Centre of Serbia. IOP was measured both with a Goldmann aplanation tonometer and dynamic contour tonometer. Central corneal thickness was measured with ultrasound pachymeter. Imaging of the retrobulbar arterial circulation by colour Doppler was performed at the Neurology Clinic, Clinical Centre of Serbia. It involved measuring of haemodynamic parameters of the ophthalmic artery, central retinal artery, and posterior ciliary arteries. Peak systolic velocity (PSV) and end-diastolic velocity (EDV) were measured, and resistive index (RI) and pulsatility index (PI) were calculated. Results. Haemodynamic arterial parameters PSV and EDV in the ophthalmic and central retinal artery after decrease of IOP were lower, while RI and PI were higher. In the posterior ciliary arteries PSV, EDV and PI were lower, and RI was higher. Conclusion. Changes of the retrobulbar arterial circulation after elevated IOP in POAG patients are important for approach and treatment, while the role of vascular factors in the supplement of the optic disc neuroretinal rim could be a key for progression backlash of glaucoma and the radix of neuroprotection.

Keywords

References

Agarwal, H.C., Gupta, V., Sihota, R., Singh, K. (2003) Pulsatile ocular blood flow among normal subjects and patients with high tension glaucoma. Indian journal of ophthalmology, 51(2): 133-8
Akarsu, C., Bilgili, Y.K.M. (2004) Color Doppler imaging in ocular hypertension and open-angle glaucoma. Graefe's archive for clinical and experimental ophthalmology / Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie, 242(2): 125-9
Baxter, G.M., Williamson, T.H., McKillop, G., Dutton, G.N. (1992) Color Doppler ultrasound of orbital and optic nerve blood flow: effects of posture and timolol 0.5%. Investigative ophthalmology & visual science, 33(3): 604-10
Butt, Z., O'Brien, C., McKillop, G., Aspinall, P., Allan, P. (1997) Color Doppler imaging in untreated high- and normal-pressure open-angle glaucoma. Invest Ophthalmol Vis Sci, 38(3): 690-6
Cioffi, G., Alm, A. (2001) Measurement of ocular blood flow. J Glaucoma, 10(Suppl): 62-4
Flammer, J., Orgül, S., Costa, V.P., Orzalesi, N., Krieglstein, G.K., Metzner, S.L., i dr. (2004) The impact of ocular blood flow in glaucoma. Prog Retin Eye Res, 21(4), str. 359-93
Flammer, J., Orgul, S. (1998) Optic nerve blood-flow abnormalities in glaucoma. Progress in Retinal and Eye Research, 17(2): 267-289
Galassi, F., Nuzzaci, G., Sodi, A., Casi, P., Vielmo, A. (1992) Color Doppler imaging in evaluation of optic nerve blood supply in normal and glaucomatous subjects. International ophthalmology, 16(4-5): 273-6
Harris, A., Williamson, T.H., Martin, B., Shoemaker, J.A., Sergott, R.C., Spaeth, G.L., Katz, J.L. (1995) Test/Retest reproducibility of color Doppler imaging assessment of blood flow velocity in orbital vessels. Journal of glaucoma, 4(4): 281-6
Harris, A., Jonescu-Cuypers, C.P. (2001) The impact of glaucoma medication on parameters of ocular perfusion. Current opinion in ophthalmology, 12(2): 131-7
Harris, A., Chung, H.S., Ciulla, T.A., Kagemann, L. (1999) Progress in measurement of ocular blood flow and relevance to our understanding of glaucoma and age-related macular degeneration. Progress in retinal and eye research, 18(5): 669-87
Joos, K.M., Kay, M.D., Pillunat, L.E., Harris, A., Gendron, E.K., Feuer, W.J., Steinwand, B.E. (1999) Effect of acute intraocular pressure changes on short posterior ciliary artery haemodynamics. British journal of ophthalmology, 83(1): 33-8
Kaiser, H.J., Schoetzau, A., Stümpfig, D., Flammer, J. (1997) Blood-flow velocities of the extraocular vessels in patients with high-tension and normal-tension primary open-angle glaucoma. American journal of ophthalmology, 123(3): 320-7
Lieb, W.E., Cohen, S.M., Merton, D.A., Shields, J.A., Mitchell, D.G., Goldberg, B.B. (1991) Color Doppler imaging of the eye and orbit. Technique and normal vascular anatomy. Archives of ophthalmology, 109(4): 527-31
Nicolela, M.T., Walman, B.E., Buckley, A.R., Drance, S.M. (1996) Ocular hypertension and primary open-angle glaucoma: a comparative study of their retrobulbar blood flow velocity. Journal of glaucoma, 5(5): 308-10
Onda, E., Cioffi, G.A., Bacon, D.R., van Buskirk, E.M. (1995) Microvasculature of the human optic nerve. American journal of ophthalmology, 120(1): 92-102
Planiol, T., Pourcelot, L., Pottier, J.M., Degiovanni, E. (1972) Study of carotid circulation by means of ultrasonic methods and thermography. Revue neurologique, 126(2): 127-41
Punjabi, O.S., Ho, H.V., Kniestedt, C., Bostrom, A.G., Stamper, R.L., Lin, S.C. (2006) Intraocular pressure and ocular pulse amplitude comparisons in different types of glaucoma using dynamic contour tonometry. Current eye research, 31(10): 851-62
Satilmis, M., Orgül, S., Doubler, B., Flammer, J. (2003) Rate of progression of glaucoma correlates with retrobulbar circulation and intraocular pressure. American journal of ophthalmology, 135(5): 664-9
Schmidt, K.G., von Rückmann, A.V., Mittag, T.W., Hessemer, V., Pillunat, L.E. (1997) Reduced ocular pulse amplitude in low tension glaucoma is independent of vasospasm. Eye (Lond), 11(Pt 4), str. 485-8
Schwenn, O., Troost, R., Vogel, A., Grus, F., Beck, S., Pfeiffer, N. (2002) Ocular pulse amplitude in patients with open angle glaucoma, normal tension glaucoma, and ocular hypertension. British journal of ophthalmology, 86(9): 981-4
Simon, J., Rankin, A. (1999) Color Doppler imaging of the retrobulbar circulation in glaucoma. Surv Ophthalmol, 43(Suppl 1):S176-82
Williamson, T.H., Harris, A. (1996) Color Doppler ultrasound imaging of the eye and orbit. Survey of ophthalmology, 40(4): 255-67
Williamson, T.H., Lowe, G.D., Baxter, G.M. (1995) Influence of age, systemic blood pressure, smoking, and blood viscosity on orbital blood velocities. Br J Ophthalmol, 79(1): 17-22