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Acta Facultatis Medicae Naissensis
2001, vol. 18, br. 1, str. 40-47
jezik rada: srpski
vrsta rada: originalan članak
Glomerulska funkcija bolesnika sa inzulin-zavisnim dijabetes melitusom evaluirana primenom 99mTc-DTPA
aKlinički centar Niš
bKlinika za endokrinologiju, dijabetes i bolesti metabolizma, Klinički centar, Niš
cIntitut za nefrologiju i hemodijalizu, Klinički centar, Niš

Sažetak

Dinamskom scintigrafijom bubrega i klirensom 99mTc-DTPA (dietilen triamino pentaacetična kiselina) procenjena je glomerulska funkcija 67 inzulin-zavisnih dijabetesnih bolesnika u odnosu na prisustvo i stepen proteinurije. Dobijeni rezultati upoređeni su sa rezultatima 23 zdrava ispitanika. Analizirani parametri (klirens i bubrežno preuzimanje 99mTc-DTPA) pokazali su povišenu glomerulsku funkciju u grupi bolesnika sa normoalbuminurijom, neizmenjenu u grupi bolesnika sa mikroalbuminurijom i sniženu u grupi bolesnika sa makroproteinurijom. U grupi bolesnika sa makroproteinurijom pokazana je značajna korelacija između klirensa 99mTc-DTPA i brzine urinarne ekskrecije proteina (R=-0,530, P<0,05). U poređenju sa kontrolom, srednja vrednost klirensa 99mTc-DTPA bila je povišena za 11 % u prvoj grupi, dok je sniženje iznosilo 5,7% u drugoj i 33,7% u trećoj grupi. Medu bolesnicima sa normalanom urinarnom ekskrecijom albumina hiper-filtracija je registrovana u 56,5% slučajeva, a srednja vrednost klirensa nadmašila je kontrolnu srednju vrednost za 20%. Normofiltracija je registrovana u 69,2% bolesnika sa mikroalbuminuri join, a hipofiltracija u svih bolesnika sa makroproteinurijom.

Ključne reči

klirens 99mTc-DTPA; inzulin-zavisni dijabetes melitus; normoalbuminurija; mikroalbuminurija; makroalbuminurija

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