Article metrics

  • citations in SCindeks: 0
  • citations in CrossRef:0
  • citations in Google Scholar:[=>]
  • visits in previous 30 days:4
  • full-text downloads in 30 days:0
article: 1 from 1  
Back back to result list
Acta Facultatis Medicae Naissensis
2001, vol. 18, iss. 1, pp. 5-11
article language: Serbian
document type: Review Paper
published on: 01/09/2009
Biodistribution and methods of nephrotropic radionuclides application
Clinical Centre Niš, Center of Nuclear Medicine

Abstract

Biokinteies of the current nephrotropic radiopharmaeeuticals (99mTc-DTPA, 123I-OIH, 99mTc-MAG3,99mTc-EC, Tc-GH, 99mTc-DMSA) is reviewed in this paper. Particular survey is related to their affinity to plasma proteins, level and mechanisms of renal extraction and distribution, as well as urinary excretion rate. Basic principles of applied methods, as well as their informations are particularly discussed. It is concluded that radionuclide methods are suitable to provide quantitative informations on specific renal functions of each kidney separately.

Keywords

References

Arnold, R.W., Subramanian, G., Mcafee, J.G., Blair, R.J., Thomas, F.D. (1975) Comparison of 99mTc complexes for renal imaging. J Nucl Med, 16(5): 357-67
Bianchi, C. (1961) Valora comparative nell indagine nefrografica diodrasl, dell hipaque et del PA1 marcati con 131L. Minerva Nucl, 5:157:161
Blaufox, M.D., Potchen, E.J., Merrill, J.P. (1967) Measurement of effective renal plasma flow in man by external counting methods. J Nucl Med, 8(2): 77-85
Blaufox, M.D., Sanderson, D.R., Tauxe, W.N. (1963) Plasmatic diatrizoate-I-123 disappearance and glomerular filtration in dog. Am J Physiol, 294: 536-540
Blaufox, M.D., Merrill, J.P. (1966) Simplified hippuran clearance: Measurement of renal function in man with simplified hippuran clearances. Nephron, 3(5): 274-81
Bogdanova, V. (1980) Glomerular filtration rate estimation using 99mTc-DTPA and single blood sample. Radiologia lugoslavica, 14, str. 327-329
Boyd, R.E., Robson, J., Hunt, F.C., Sorby, P.J., Murray, I.P., McKay, W.J. (1973) 99Tcm gluconate complexes for renal scintigraphy. Br J Radiol, 46(548): 604-12
Conway, J.J., Belman, A.B., King, L.R. (1974) Direct and indirect radionuclide cystography. Semin Nucl Med, 4(2): 197-211
Daly, M.J., Milutinovic, J., Rudd, T.G., Phillips, L.A., Flalkow, P.J. (1978) The normal 99mTc-DMSA renal image. Radiology, 128(3): 701-4
Davidson, R.A., Barri, Y.M., Wilcox, C.S. (1994) The simplified captopril test: an effective tool to diagnose renovascular hypertension. Am J Kidney Dis, 24(4): 660-4
de Lange, M.J., Piers, D.A., van Luijk, W.H.J., Meijer, S. (1988) Renal handling of 99mtc-dmsa: Peritubular uptake or glomerular filtration and reapsorption. J Nucl Med, 29: 778
Diffey, B.L., Hall, F.M., Corfield, J.R. (1976) The 99mTc-DTPA dynamic renal scan with deconvolution analysis. J Nucl Med, 17(5): 352-5
Fine, J.E., Blaufox, M.D. (2001) Renal scintigraphy: An update. in: Applied radiology, 19-25
Freeman, L.M., Meng, C.H., Bernstein, R.G., Blaufox, M.D. (1969) Rapid, sequential renal blood flow scintiphotography. Radiology, 92(4): 918-23
Fritzberg, A.R., Kasina, S., Eshima, D., Johnson, D.L. (1986) Synthesis and biological evaluation of technetium-99m MAG3 as a hippuran replacement. J Nucl Med, 27(1): 111-6
Gates, G.F. (1984) Computation of glomerular filtration rate with Tc-99m DTPA: An in-house computer program. J Nucl Med, 25(5): 613-8
Gordon, I., Evans, K., Peters, A.M., Kelly, J., Morales, B.N., Goldraich, N., Yau, A. (1987) The quantitation of 99Tcm-DMSA in paediatrics. Nucl Med Commun, 8(8): 661-70
Groshar, D., Embon, O.M., Sazbon, A., Koritny, E.S., Frenkel, A. (1988) Radionuclide assessment of bladder outlet obstruction: a noninvasive (1-step) method for measurement of voiding time, urinary flow rates and residual urine. J Urol, 139(2): 266-9
Hauser, W., Atkins, H.L., Nelson, K.G., Richards, P. (1970) Technetium-99m DTPA: A new radiopharmaceutical for brain and kidney scanning. Radiology, 94(3): 679-84
Hilson, A.J., Maisey, M.N., Brown, C.B., Ogg, C.S., Bewick, M.S. (1978) Dynamic renal transplant imaging with Tc-99m DTPA (Sn) supplemented by a transplant perfusion index in the management of renal transplants. J Nucl Med, 19(9): 994-1000
Hosokawa, S., Kawamura, J., Yoshida, O. (1978) Basal studies on intrarenal localization of renal scanning agent 99mTc-DMSA. Acta Urol Jap, 24, str. 61-65
Kabasakal, L. (2000) Technetium-99m ethylene dicysteine: A new renal tubular function agent. Eur J Nucl Med, 27(3): 351-7
Kabasakal, L., Halaç, M., Yapar, A.F., Alkan, E., Kanmaz, B., Onsel, C., Sönmezoglu, K., Ayaz, M., Kalender, B., Sayman, H.B., Uslu, I. (1999) Prospective validation of single plasma sample 99mTc-ethylenedicysteine clearance in adults. J Nucl Med, 40(3): 429-31
Kawamura, J., Hosokawa, S., Yoshida, O., Fujita, T., Ishii, Y., Torizuka, K. (1978) Validity of 99mTc dimercaptosuccinic acid renal uptake for an assessment for individual kidney function. J Urol, 119(3): 305-9
Kenny, R.W., Ackery, D.M., Fleming, J.S., Goddard, B.A., Grant, R.W. (1975) Deconvolution analysis of the scintillation camera renogram. Br J Radiol, 48(570): 481-6
Kimbel, K.H. (1956) Discussion. in: Fellinger K., Vetter H. [ed.] Radioaktive Isotope in Klinik und Forschung, München: Urban und Schwarzenberg, Vol. 2., p 150
Klopper, J.F., Hauser, W., Atkins, H.L., Eckelman, W.C., Richards, P. (1972) Evaluation of 99m Tc-DTPA for the measurement of glomerular filtration rate. J Nucl Med, 13(1): 107-10
Lin, T.H., Khentigan, A., Winchell, H.S. (1974) A 99mTc-chelate substitute for organoradiomercurial renal agents. J Nucl Med, 15(1): 34-5
Maher, F.T., Strong, C.G., Elveback, L.R. (1971) Renal extraction ratios and plasma-binding studies of radioiodinated o-iodohippurate p-aminohippurate in man. Mayo Clin Proc, 46(3): 189-92
Mcafee, J.G., Gagne, G., Atkins, H.L., Kirchner, P.T., Reba, R.C., Blaufox, M.D., Smith, E.M. (1979) Biological distribution and excretion of DTPA labeled with Tc-99m and In-111. J Nucl Med, 20(12): 1273-8
Mcafee, J.G., Grossman, Z.D., Gagne, G., Zens, A.L., Subramanian, G., Thomas, F.D., Fernandez, P., Roskopf, M.L. (1981) Comparison of renal extraction efficiencies for radioactive agents in the normal dog. J Nucl Med, 22(4): 333-8
Mcafee, J.G., Wagner, H.N. (1960) Visualization of renal parenchyma by scintiscanning with Hg203 neohydrin. Radiology, 75: 820-1
Müller-Suur, R., Gutsche, H.U. (1995) Tubular reabsorption of technetium-99m-DMSA. J Nucl Med, 36(9): 1654-8
Oeser, H., Billion, H. (1952) Funktionelle Strahlen diagnostik durch etiketeirte oentgenlontrastmittle. Fortsch. Rontgensir, 76: 431
O'Reilly, P.H., Lawson, R.S., Shields, R.A., Testa, H.T. (1979) Idiopathic hydronephrosis: the diuresis renogram: a new non-invasive method of assessing equivocal pelvioureteral junction obstruction. J Urol, 121(2): 153-5
Peters, A.M., Jones, D.H., Evans, K., Gordon, I. (1988) Two routes for 99mTc-DMSA uptake into the renal cortical tubular cell. Eur J Nucl Med, 14(11): 555-61
Piepsz, A., Denis, R., Ham, H.R., Dobbeleir, A., Schulman, C., Erbsmann, F. (1978) A simple method for measuring separate glomerular filtration rate using a single injection of 99mTc-DTPA and the scintillation camera. J Pediatr, 93(5): 769-74
Russell, C.D., Rowell, K., Scott, J.W. (1986) Quality control of technetium-99m DTPA: correlation of analytic tests with in vivo protein binding in man. J Nucl Med, 27(4): 560-2
Schlegel, J.U., Hamway, S.A. (1976) Individual renal plasma flow determination in 2 minutes. J Urol, 116(3): 282-5
Taplin, G.V., Meredith, O.M., Kade, H., Winter, C.C. (1956) The radioisotope renogram: An external test for individual kidney function and upper urinary tract patency. J Lab Clin Med, 48(6): 886-901
Tauxe, W.N., Dubovsky, E.V., Kidd, T.E. (1984) Comparison of measurement of effective renal plasma flow by single plasma sample and plasma disappearance slope/volume methods. Eur J Nucl Med, 9(10): 443-5
Taylor, A., Eshima, D., Fritzberg, A.R., Christian, P.E., Kasina, S. (1986) Comparison of iodine-131 OIH and technetium-99m MAG3 renal imaging in volunteers. J Nucl Med, 27(6): 795-803
Taylor, A., Eshima, D., Christian, P.E., Wooten, W.W., Hansen, L., Mcelvany, K. (1988) Technetium-99m MAG3 kit formulation: Preliminary results in normal volunteers and patients with renal failure. J Nucl Med, 29(5): 616-22
Treves, S., Martinez, D.A., Dauss, M.A. (1976) Cellular localisation of the WmTc radiophamiaceutical by radio-autography. J Nucl Med, 17: 536
Tubis, M., Posnick, E., Nordyke, R.A. (1960) Preparation and use of I 131 labeled sodium iodohippurate in kidney function tests. Proc Soc Exp Biol Med, 103: 497-8
van de Ven, P.J., de Klerk, J.M., Mertens, I.J., Koomans, H.A., Beutler, J.J. (2000) Aspirin renography and captopril renography in the diagnosis of renal artery stenosis. J Nucl Med, 41(8): 1337-42
Wedeen, R.P., Jernow, H.I. (1968) Autoradiographic study of cellular transport of hippuran-125I in the rat nephron. Am J Physiol, 214(4): 776-85
Weiss, E.R., Blahd, W.H., Winston, M.A., Krishnamurthy, G.T., Hartenbower, D.L., Thomas, P.B. (1971) The scintillation camera in the dynamic evaluation of renal disorders. Radiology, 98(1): 165-9
Wong, D.C., Rossleigh, M.A., Farnsworth, R.H. (1999) F+0 diuresis renography in infants and children. J Nucl Med, 40(11): 1805-11