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Tehnika
2021, vol. 76, br. 1, str. 9-14
Ispitivanje uticaja mehanohemijskog procesiranja na rastvorljivost verapamil hidrohlorida
Stanković Ana V.a ORCID, Jovanović Sonja M.b ORCID
aSrpska akademija nauke i umetnosti (SANU), Institut tehničkih nauka, Beograd, Srbija
bUniverzitet u Beogradu, Institut za nuklearne nauke Vinča, Beograd-Vinča, Srbija

e-adresa: anastankovic@itn.sanu.ac.rs
Projekat:
Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije (institucija: Institut tehničkih nauka SANU, Beograd) (MPNTR - 451-03-68/2020-14/200175)

Ključne reči: verapamil hidrohlorid; mehanohemijsko procesiranje; rastvorljivost; bioraspoloživost
Sažetak
Rastvorljivost lekova predstavlja veoma važno svojstvo koje direktno utiče na njihovu primenu. S obzirom na činjenicu da rastvorljivost može delovati kao ograničavajući faktor u procesu apsorpcije leka, takođe može uticati i na njegovu bioraspoloživost. Više od 40% potencijalnih lekova su slabo rastvorni u vodi što ima za posledicu da važni farmaceutski proizvodi ne ostvare komercijalnu primenu ili ne postižu svoj potpuni potencijal. U ovom radu ispitivana je mogućnost poboljšanja rastvorljivosti verapamil hidrohlorida (VHCl) primenom mehanohemijskog tretmana. Uticaj mehanohemijskog procesiranja na fizičkohemijska svojstva VHCl-a ispitan je primenom metoda XRPD, FTIR i Ramanske spektroskopije, kao i FESEM analize. Osim toga, određena je i raspodela veličina čestica. Rastvorljivost VHCl prahova nakon mehanohemijskog procesiranja određena je UV-Vis spektrofotometrijom. Konačno, rastvorljivost VHCl je korelisana sa srednjom veličinom čestica, strukturnim i morfološkim karakteristikama.
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O članku

jezik rada: srpski
vrsta rada: izvorni naučni članak
DOI: 10.5937/tehnika2101009S
primljen: 29.01.2021.
prihvaćen: 04.02.2021.
objavljen u SCIndeksu: 06.03.2021.
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