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Medicinski časopis
2018, vol. 52, br. 3, str. 98-104
jezik rada: engleski
vrsta rada: izvorni naučni članak
doi:10.5937/mckg52-17769


Uticaj dužine pušenja cigareta na funkciju endotelijalnih ćelija
aKharkiv National Medical University, Department of Biochemistry, Kharkiv, Ukraine
bOutpatient Department of Kharkiv, City Student Hospital, Kharkiv, Ukraine

e-adresa: popovatatyanamikh@gmail.com

Sažetak

Cilj. Pušenje cigareta predstavlja važan faktor za razvoj kardiovaskularnih bolesti. Količina i dužina upotrebe cigareta u direktnoj su korelaciji sa povećanjem kardiovaskularne patologije. Cilj našeg istraživanja bio je da se utvrdi uticaj dužine pušenja na nitrat, nitrit, S-nitrosotiol i nivo endothelin-1 u pljuvački pušača. Metode. Za potrebe ove studije angažovano je ukupno 60 ispitanika, koji su podeljeni u četiri grupe na osnovu dužine korišćenja cigareta: nepušači - kontrolna grupa (n = 15); grupa I (n = 15) - koriste cigarete dve godine; grupa II (n = 15) - četiri godine i grupa III (n = 15) - šest godina. Izmereni su krvni pritisak, težina i visina svih ispitanika. Izračunat je indeks telesne mase. Određivanje nitrata, nitrita, S-nitrosotiola i endotelina-1 obavljeno je na svakom uzorku pljuvačke sakupljene od 60 ispitanika. Rezultati. Ni sistolni ni dijastolni krvni pritisak nisu se razlikovali između kontrolne grupe i grupe I. Ovi parametri su bili znatno veći kod grupa II i III u poređenju s kontrolnom grupom. Pušači svih grupa i nepušači imali su normalne vrednosti indeksa telesne mase. Nivoi salivarnih nitrata, nitrita i S-nitrosotiola znatno su niži u grupama II i III u poređenju s kontrolnom grupom. Koncentracije salivarnog endotelina-1 bile su znatno veće kod ispitanika II i III grupe nego kod kontrolne grupe. Zaključak. U ovoj studiji znatne razlike između pušača i nepušača u nivoima stabilnih metabolita NO i endotelina-1 posledica su uzročnih efekata pušenja.

Ključne reči

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