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2020, vol. 39, br. 4, str. 452-459
Značajni markeri koji ukazuju na koronarnu bolest kod gojaznih pacijenata - ADMA i neopterin
aHitit University, Faculty of Science and Arts, Department of Molecular Biology and Genetics, Corum, Turkey
bHitit University, Faculty of Medicine, Department of Internal Medicine, Corum, Turkey
cHigh Education University, Faculty of Medicine, Department of Biochemistry, Ankara, Turkey

e-adresaavci.emre@yahoo.com
Sažetak
Uvod: Gojaznost je odgovorna je za visoki morbiditet i mortalitet, kako u razvijenim zemljama tako i u zemljama u razvoju. Povezana je sa mnogim hroničnim bolestima i bolestima metabolizma. Dokazano je da je asimetrični dimetilaginin (ADMA) biomarker endotelne disfunkcije kod ljudi, a u mnogim državama je uočeno da je povećan ADMA povezan sa rizikom od kardiovaskularnih bolesti (CVD) prijavljen je u mnogim državama. U mnogim istraživanjima skorijeg datuma ukazano je na neopterin (NP) proizveden monocitima/makrofazima kao odgovor na stimulaciju interferon-gama (IFN-g). Cilj ove studije je da se ispita nivo ADMA i NP koji mogu biti smernica za ranu dijagnoze bolesti koronarnih arterija kod gojaznih pacijenata. Metode: Ovo je originalna istraživačka studija u kojoj su upoređeni nivoi ADMA i NP kod 50 pacijenata (25 muškaraca/25 žena) kojima je dijagnostikovana gojaznost sa istim vrednostima kod 30 zdravih pojedinaca (kontrolna grupa od 15 muškaraca/15 žena). Pri određivanju parametara korišćena je metoda tečne hromatografije visokih performansi (HPLC). Rezultati: Utvrđeno je da su nivoi ADMA i NP kod gojaznih pojedinaca značajno viši od onih utvrđenih kod pojedinaca iz kontrolne grupe. Otkriveno je da su vrednosti ADMA veće kod gojaznih ispitanika (0,71 ± 0,24 mmol/L) u poređenju sa vrednostima kod zdravih ispitanika (0,58 ± 0,16 mmol/L) (p < 0,05). Utvrđeno je značajno povećanje nivoa neopterina u serumu kod gojaznih ispitanika (8,8 ± 3,5 mmol/L) u poređenju sa kontrolnom grupom (4,9 ± 1,69 mmol/L) (p < 0,05). Takođe, utvrđena je visoka pozitivna korelacija između vrednosti NP i ADMA kod gojaznih pojedinaca (r = 0,954). Zaključak: Naše istraživanje je otkrilo da gojazni ispitanici imaju viši nivo ADMA i neopterina. Ovi rezultati su pokazali da i ADMA i NP nivoi mogu biti potencijalni faktori rizika za koronarnu bolest srca kod gojaznih pacijenata.
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O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
PMC ID: PMC7710377
DOI: 10.5937/jomb0-24683
objavljen u SCIndeksu: 02.10.2020.
metod recenzije: dvostruko anoniman
Creative Commons License 4.0

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